Was happy to join @boston25news.com 🎥for a discussion of alcohol and heart disease yesterday! Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀 www.boston25news.com/news/local/d... @massgeneralbrigham.bsky.social

🆕 New in AJPC: High-Density Lipoproteins, Part 1 Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels. 🔗 www.sciencedirect.com/science/arti... #HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology

An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...

Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in @CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !! Are genetic and contemporary risk factors as powerful as traditional RFs? #CardioSky #cvPrev

Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH! Watch this space for insights and work from our faculty! #CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social

Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease www.nature.com/articles/s43...

Steffensen, Rasmussen, et al. show that deep whole-exome sequencing of human atherosclerotic plaques reveals that the expansion of large mutated clones within plaque tissue is an intrinsic feature of human atherosclerosis: buff.ly/zdEM0dm

Peer Review In Peril @aniloza.bsky.social "But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending" www.statnews.com/2025/05/27/r... #Cardiosky

📢 Just published! New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank. www.sciencedirect.com/science/arti... #LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank

CETP inhibitors revived? #CardioSky

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

Wow!!! These human genetic insights could enable the next generation of pain management therapies: rupress.org/jem/article/... Fascinating @jem.org article!

In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity www.jacc.org/doi/10.1016/...

Here's the thing... pseudoscience can't do this. Only real science can. www.nytimes.com/2025/05/15/h...

Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy. Register us02web.zoom.us/meeting/regi... @drmarthagulati.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social .

Lp(a) & recurrent atherosclerotic CV events: US Family Heart Database #CardioSky academic.oup.com/eurheartj/ad... @hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social

Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS... @mgbresearch.bsky.social @harvardmed.bsky.social

Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday www.pnas.org/doi/10.1073/...

Nice of @indiaspora.bsky.social to feature the OurHealth Study in their newsletter! #cvPrev #SouthAsianCVD #CardioSky

Great study!

Thrilled to join Ankur Kalra and Jaideep Patel on the Parallax Podcast to discuss South Asian Cardiometabolic Disease We get into: - Knowledge gaps - Lifestyle and Genetics - Common difficulties for the cardiologist in guiding South Asian patients #SouthAsianCVD bit.ly/4jVIuti

Our @aspcardio.bsky.social statement on South Asians & Cardiometabolic Health in @ajpcardio.bsky.social I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social 🙏🏽 to our entire talented team who brought this to life 📎 shorturl.at/4bJGz #CVPrev #Cardiosky

Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

“Studies of the past tell us that nitpicking the particular semantics of the term ‘concentration camp’ as they pertain to a place the government is actively sending people with no criminal history is highly associated with national stability,” said historian Kristen Boyd theonion.com/histori...

The Trump regime is now using US Attorneys to intimidate academic journals by sending them letters demanding they explain how they ensure ‘viewpoint diversity.’ Journal editors should be public about this and coordinate to refuse to comply with these fascist tactics.

@kevinh-phd.bsky.social Kevin Hall’s work has been so important and enlightening to nutrition science and preventive cardiology. I thought at least his work would be valued and supported with the stated priorities. This is truly saddening to hear.

In a new Science study, researchers report compelling evidence for a gut-joint axis involving bile acid metabolism and GLP-1 signaling in osteoarthritis development, advancing the understanding of osteoarthritis pathogenesis and opening new avenues for therapy. scim.ag/3Ec0bFM #SciencePerspective

In the Review, Karine Clément and colleagues discuss enhancing #adipose tissue plasticity: progenitor cell roles in #metabolic health rdcu.be/ehEqH #EndoSky

Emerging evidence suggests a continuum that includes monogenic, oligogenic, and polygenic contributions, revealing their complementary roles in type 2 #diabetes pathophysiology www.thelancet.com/journals/lan... #genetics #MedSky #EndoSky

FYI: New online! From genome to drug: the hidden story of diversity

The BARCODE1 study assessed the use of a polygenic risk score to screen for prostate cancer. Of the 468 persons in at least the 90th percentile of genetic risk who underwent MRI and prostate biopsy, 187 (40.0%) had prostate cancer. Full study: nej.md/44jT8Fn #MedSky #Oncology

In people with diabetes, GLP-1 and SGLT2i drugs were associated with less Alzheimer's disease and related dementias jamanetwork.com/journals/jam...

A timely article as we head towards recession... In the US, the mortality gap between top & bottom wealth quartiles is wider than in Europe. The wealthiest quartile of Americans have had similar survival to the poorest quartile of Northern/Western Europeans. www.nejm.org/doi/pdf/10.1...

The Trump administration’s new Medicare policy did not include a proposed rule that would have expanded coverage of anti-obesity drugs to an additional 3.4 million adults. This is a big mistake.

The Trump administration rejected a Biden plan that would have required Medicare and Medicaid to cover obesity drugs and expanded access for millions. www.nytimes.com/2025/04/04/h...

Well… that is unfortunate

A randomized trial of the Western diet vs African heritage diet finds the former is pro-inflammatory, leads to impaired immune response to microbial stimulation, and changes are persistent for weeks after a short duration @naturemedicine.bsky.social www.nature.com/articles/s41...

It is 2002. I am 18 years old. We are in a once-in-a-generation economic crisis. It is 2008. I am 24 years old. We are in a once-in-a-generation economic crisis. It is 2020. I am 36 years old. We are in a once-in-a-generation economic crisis. It is 2025. I am 41 years old. We are in a—

Deep learning-quantified body composition from cardiac PET/CT & CV outcomes: a multicentre study #CardioSky #AI academic.oup.com/eurheartj/ad... @escardio.bsky.social @hsbhatia.bsky.social @psatishmd.bsky.social @drmonalidesai.bsky.social @victoriadelgadomd.bsky.social @gimelliale.bsky.social

Single combined measure of LDL, hsCRP & Lp(a) among initially healthy European men/women was predictive of incident MACE during a 20-yr period: EPIC-Norfolk study #CardioSky academic.oup.com/eurheartj/ad... @escardio.bsky.social @jimjanuzzi.bsky.social @hsbhatia.bsky.social @vietheartpa.bsky.social

Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social professional.heart.org/en/education...

PURSUIT: AZD0780, a novel, once-daily oral molecule inhibitor, had a robust, dose-dependent effect in ↘️ LDL-C & a favorable safety profile in pts w/ hypercholesterolemia already on background moderate- or high-intensity statin treatment. bit.ly/3XG7Oe2 #ACC25 #JACC #CardioSky #MedSky

The increased income gradient and life expectancy in Sweden over 60 years, especially for preventable diseases "suggesting that higher-income individuals are more rapidly adopting healthier lifestyles" www.pnas.org/doi/full/10.... open-access

Important paper on rethinking heart disease, with a focus on atheroma and primary prevention, not just blood supply impairment (reactive, today's mode of secondary prevention) A @thelancet.bsky.social Commission www.thelancet.com/journals/lan...

The reduction in CRP with oral semaglutide is near maximal at the first time point measured, 13 weeks, whereas body weight continues to decline over time, again dissociating weight loss from the anti-inflammatory actions of GLP-1 medicines www.nejm.org/doi/full/10....

Exciting new development in lipid field! The early Phase 2 #PURSUIT trial showed a novel oral #PCSK9i (that can be taken with food) lowered LDL-C by 51% at 12 weeks. 84% achieved LDL-C of <70 mg/dL. #ACC25 @accintouch.bsky.social

Clever new study using #wearables data from from All Of Us Research Study and @medillschool.bsky.social The "Daily Heart Rate per Step" (DHRPS) ("Durpaz?") as a metric for health www.ahajournals.org/doi/epdf/10.... #cvPrev #CardioSky NYT: www.nytimes.com/2025/03/29/h...