Read our March Issue, featuring osteoporosis, adrenal tumours, type 2 diabetes, genetics, familial hypercholesterolaemia, Addison’s disease, menopausal hormone treatment, paediatric obesity, type 1 diabetes screening & much more tinyurl.com/mwfu4c6m #MedSky #EndoSky #CardioSky #OncSky #RheumSky

Ongoing #surveillance and well designed national studies on #diabetes prevalence and incidence are essential to accurately monitor diabetes burden www.thelancet.com/journals/lan... #FREE to read with registration (also FREE) #MedSky #EndoSky

VEXAS syndrome is a newly discovered multisystemic disease affecting most organs. A Review provides a comprehensive overview of VEXAS syndrome, including the disease's discovery, diagnosis, and treatment: spkl.io/63322AsNa8

Diabetic ketoacidosis (#DKA) is an acute complication associated mainly with type 1 #diabetes, but can occur in type 2 & other forms of diabetes, & is one of the most preventable causes of morbidity and mortality for individuals with diabetes www.thelancet.com/journals/lan... #T1D #T2D #FREE w/reg

New—Quest for the holy grail: an effective drug for obesity thelancet.com/journals/lan... #obesity #FREE to read with registration (also FREE) #MedSky #EndoSky

Published in @ebiomedicine.bsky.social Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion www.thelancet.com/journals/ebi... non-functioning #adrenal #tumours #Cushing's syndrome #OpenAccess #MedSky #EndoSky

Our March issue is now live at www.thelancet.com/gastrohep! Content includes: #alcohol, #IBD, #HBV, #MASLD, #SIMD (#SIBO) + more! #GastroSky #LiverSky #MedSky

Arterial hypertension affects an estimated 25–30% of adults worldwide. Innovative approaches are needed to improve hypertension care. A new Therapeutics Review explores new drug therapies for hypertension: spkl.io/63322AtTNi

Published in @thelancet.com Adult #obesity and risk of severe #infections: a multicohort study with global burden estimates www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky

Want to stay up to date with the latest clinical research & reviews? 📚 Discover The Lancet’s Clinical Resources: spkl.io/63324AsfDu

Since its first description by Thomas Addison in 1855, dramatic advancements have been made in the management of Addison's disease, transforming it from a predominantly lethal disease to a manageable condition with, in most cases, expected long-term survival www.thelancet.com/journals/lan... #MedSky

New @thelancet.com - Efimosfermin alfa (BOS-580) once per month in people with MASH with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial www.thelancet.com/journals/lan... #LiverSky #MedSky #EndoSky #GastroSky

People with a high #genetic #susceptibility to type 2 #diabetes could be especially affected by a diabetogenic environment, highlighting the need for public health measures www.thelancet.com/journals/lan... #T2D #MedSky #EndoSky

The siRNA therapeutic inclisiran, on top of standard-of-care treatment, results in sustained lowering of LDL cholesterol in this paediatric patient population, with a favourable safety & tolerability profile that is consistent with studies in adult populations tinyurl.com/3hn8243k #HeFH #CardioSky

Almost all side effects on statin labels not caused by statins, finds major meta-analysis; authors call for labels to be updated. Find out more 👉 spkl.io/63324AsjHO

Although mortality and cardiovascular event rates were similar across treatments, surgery led to better biochemical control and more favourable comorbidity outcomes thelancet.com/journals/lan... #bilateral #adrenal #tumours #adrenalectomy #cortisol excess #MedSky #EndoSky #OncSky

A 10-fold increase in the detection of adrenal tumours has been reported over the past 30 years thelancet.com/journals/lan... #phaeochromocytomas #paragangliomas #PPGLs #MedSky #EndoSky #OncSky

Patient education on #glucocorticoid stress dosing is key to the effective prevention of #adrenal #crises and their associated morbidity and mortality www.thelancet.com/journals/lan... #Addison's disease #adrenal insufficiency #MedSky #EndoSky

Association of intraoperative dexamethasone administration with postoperative delirium and the role of hyperglycaemia Intraoperative dexamethasone was associated with lower risk of postoperative #delirium, but not in patients with hyperglycaemia www.thelancet.com/journals/ecl... #MedSky #Surgery

Published in @thelancetph.bsky.social The effect of Indigenous American genomic ancestry on type 2 #diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study www.thelancet.com/journals/lan... #T2D #Mexico #OpenAccess #MedSky #EndoSky

New—A new dawn for osteoporosis drug development thelancet.com/journals/lan... #osteoporosis #FREE to read #MedSky #EndoSky #RheumSky

For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan... #EndoSky

🚀 Just launched – our new #goldopenaccess journal on medical imaging and theranostics! Learn more about the journal’s mission and explore related content from The Lancet Group today: hubs.li/Q041CgFF0 #medsky

On #WorldCancerDay, stay up to date with the latest oncology content published across The Lancet Group. Explore our Specialty Collection: spkl.io/63327AsDNU

"The results of this randomised controlled trial provide rationale for a shorter, 3-month course of #romosozumab compared with the standard 12-month regimen, thereby reducing cost and injection burden while potentially limiting cardiovascular risk" www.thelancet.com/journals/lan... #OpenAccess

Ongoing surveillance and well designed national studies on #diabetes prevalence and incidence are essential to accurately monitor diabetes burden www.thelancet.com/journals/lan... #FREE to read with registration (also FREE) #MedSky #EndoSky

#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses www.thelancet.com/journals/lan... #prolactinomas #MedSky #EndoSky #OncSky

Heart failure with reduced ejection fraction (HFrEF) accounts for approx. 50% of all patients with heart failure. A Seminar details the current diagnostic and pharmacological management of patients with HFrEF: spkl.io/63322AS3HC

As type 1 #diabetes #screening programmes expand, clinicians will increasingly encounter a new group of people: adults who test positive for islet autoantibodies but have not yet been diagnosed with diabetes www.thelancet.com/journals/lan... #T1D #MedSky #EndoSky

Type 1 #diabetes affects individuals of all ages, with different clinical priorities and support needs at different stages of life www.thelancet.com/journals/lan... #T1D #MedSky #EndoSky

🆕 AI-enabled stethoscopes show promise for improving diagnosis of cardiovascular conditions, UK trial finds. Find out more: spkl.io/63324AS3BE

Clinical features, investigation, and management of Addison's disease thelancet.com/journals/lan... #Addison's disease #adrenal insufficiency #adrenal crisis #MedSky #EndoSky

Evaluating baseline risk of #breast #cancer before prescription of #MHT should be considered a minimum standard alongside education on risk factors that can help decrease the risk of breast cancer with or without using MHT www.thelancet.com/journals/lan... #menopausal #hormone #treatment #menopause

The anticipated availability of continuous ketone monitoring (CKM) has the potential to reduce the risk of developing #DKA, one of the most life-threatening acute complications of type 1 and type 2 #diabetes www.thelancet.com/journals/lan... #diabetic ketoacidosis #T1D #T2D FREE to read w/reg

Application of continuous glucose monitoring and automated insulin delivery technologies for #pregnant #women with type 1, type 2, or gestational #diabetes: an international consensus statement www.thelancet.com/journals/lan... #CGM #AID #T1D #T2D #GDM #FREE to read with reg (also FREE) #EndoSky

New—3 months vs 12 months of #romosozumab for #postmenopausal #osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial thelancet.com/journals/lan... #BoneHealth #WomensHealth #OpenAccess #MedSky #EndoSky #RheumSky

Investing in strengthened care pathways for #diabetes, including early detection and empowering people to understand & manage their diabetes, will support sustainable health-care systems and improve patient outcomes and quality of life www.thelancet.com/journals/lan... #MedSky #EndoSky #CardioSky

The siRNA therapeutic inclisiran, on top of standard-of-care treatment, results in sustained lowering of LDL cholesterol in this paediatric patient population, with a favourable safety & tolerability profile that is consistent with studies in adult populations www.thelancet.com/journals/lan... #HeFH

Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease. In @lancetgastrohep.bsky.social, a Review summarises recent breakthroughs and potential future developments: spkl.io/63323Aq7BR

New—Menopausal hormone treatment and breast cancer www.thelancet.com/journals/lan... #MHT #HRT #menopause #breastcancer #WomensHealth #MedSky #EndoSky #WomensHealthSky

"From the 1980s to the 2010s we observed an increasing difference in prevalence of type 2 #diabetes between participants with a high and low #genetic susceptibility to the disease" www.thelancet.com/journals/lan... #T2D #MedSky #EndoSky

The ELSA study is the first to explore the feasibility of implementation and psychosocial effect of general population #screening for #paediatric type 1 #diabetes in the UK www.thelancet.com/journals/lan... #T1D #FREE to read #MedSky #EndoSky

In this adolescent patient population with #HeFH and elevated #LDL #cholesterol despite standard of care, inclisiran was effective in lowering LDL cholesterol, showing sustained efficacy over 2 years of treatment, with a reduction of −33·7% from baseline at day 720 www.thelancet.com/journals/lan....

Health-care providers should consider #Addison's disease as a differential in a wide variety of presentations, and understand the correct interpretation and limitations of widely available cortisol assays thelancet.com/journals/lan... #adrenal insufficiency #adrenal crisis #MedSky #EndoSky

Despite oral corticosteroid replacement therapy, people with #Addison's disease have increased mortality in addition to reduced HRQoL and working ability thelancet.com/journals/lan... #adrenal insufficiency #adrenal crisis

Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan... #osteoporosis #EndoSky

All patients with #Addison’s disease should be given a steroid emergency card and provided with and trained to use a glucocorticoid injection kit www.thelancet.com/journals/lan... #adrenal insufficiency #adrenal crisis

Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults www.thelancet.com/journals/lan... #adrenal insufficiency #MedSky #EndoSky

"We provide the most extensive global estimates of #GLP-1 receptor agonist eligibility for #obesity to date, showing that a substantial population across all economic strata worldwide would also qualify for GLP-1 receptor agonists" www.thelancet.com/journals/lan... #obesity #FREE to read #EndoSky

Reaching #prediabetes #remission is linked to a decades-long benefit, halving the risk of #cardiovascular death or hospitalisation for #heartfailure in diverse populations. Targeting remission might represent a new approach to cardiovascular prevention www.thelancet.com/journals/lan... #OpenAccess