Delighted to share our latest research from the 23andMe Research Team, just published in @nature.com ! We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A short thread 🧵👇

Padraic Daniel Berlin David Dubar Jr Corey Myers Paul Delgado Jr (Brought an untrained aggressive dog and attacked residents) Andy Chavez Tee Rico Javier Puente (Broke residents' ribs in two instances, tear gassed and pointed A GRENADE LAUNCHER THAT HE GOT SOME REASON WAS ALLOWED TO HAVE)

In patients with symptomatic single-vessel chronic total occlusion, percutaneous coronary intervention for coronary chronic total occlusion (CTO PCI) improves angina beyond placebo. Get the details in #JACC: https://bit.ly/4tfFPza #ACC26 #PCI #CTO #CardioSky

Endorse. www.nytimes.com/2026/03/27/o...

Great work from the Fahed group. The amplified importance of these biomarkers in younger adults is absolutely striking. www.jacc.org/doi/10.1016/...

One of the many perks of living in the Bay Area is having SFO as my home airport. Best airport in the country, hands down. 😎

From Grok to Grammarly, more and more people are finding that AI systems have appropriated their identities for financial gain. I wrote about another of those companies — Spotify — taking a belated step to do something about it www.platformer.news/spotify-arti...

Just created a new postdoctoral position at UCSF doing cardiovascular deep learning and common-variant genetics in my lab. Please take a look at the posting and send me an email if interested! postdocs.ucsf.edu/postdoctoral...

Get Your Cholesterol Even Lower and Start Younger, New Guideline Says www.nytimes.com/2026/03/13/h...

Saving some of my favorite elements from the 2026 ACC/AHA dyslipidemia guidelines in this thread:

ACC/AHA & 9 other leading medical associations released an updated clinical guideline for managing #dyslipidemia. About 1 in 4 US adults has high LDL-C, raising risk of heart attack & stroke. Get the details in #JACC: https://bit.ly/4cLB0J0 #ClinicalGuidelines #cvLipids #ASCVD #CardioSky

New dyslipidemia guidelines have finally arrived! So much is new & improved compared to prior US guidelines! A broader understanding of lipid risk/reatment (beyond cholesterol), improved thinking about younger adults & lifetime prevention, & so much more! #CardioSky www.jacc.org/doi/10.1016/...

A tomahawk missile costs the taxpayers the same amount of money as one five-year major NIH research grant. Remember that every time they tell us one of those missed the target, blew up paintings of enemy aircraft or tanks, or was the fifth and unnecessary hit on the same target.

👋 www.cbsnews.com/news/fda-vac...

Sorry I'm not more open-minded about LLMs, it's just some fucking maniacs shoveled out a bunch of useless bloatware featuring that technology, did not give me any chance to opt out, reorganized the entire economy around it, zeroed out gains made by green energy, and made it impossible to buy RAM

In December we published a @jaccjournals.bsky.social Brief Report demonstrating that ascending aortic diameter can be partially estimated from the ECG.

It's so cool that the fbi is basically the make a wish foundation for one podcaster

The Olympics Are Not Weird Enough www.nytimes.com/2026/02/15/o...

A poignant piece from my colleague at the Stanford Prevention Research Center. www.nature.com/articles/s41...

Nice work, @just-jack-1.bsky.social and several other Stanford Cardiology fellows and recent alums! Stanford is a wonderful place for trainees who want to conduct collaborative and high impact research. #CardioSky www.nature.com/articles/s41...

Incredibly important story that everyone should read. These are not disorganized lone actors, but well-funded and powerful networks to be treated as serious threats. They are using our work to push a eugenicist and racist agenda that is scientifically invalid and morally reprehensible.

Proud to share the inaugural JACC Cardiovascular Statistics annual report, offering a clear-eyed understanding of cardiovascular health in the United States. Where we stand. Where we've made gains. And where we're falling behind. #JACCStats #medsky #cardiosky www.jacc.org/doi/10.1016/...

good morning from the Dorktown slack room

We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis. nature.com/articles/s41... 1/10

Thrilled to share that I’ve been awarded an AHA Postdoctoral Fellowship! So grateful for the support and honored to have the opportunity to advance my research in precision nutrition for CVD prevention. Huge thanks to my mentor @shoaclarke.bsky.social and collaborators for their guidance! 🫀🧬

Got another stamp for my 2025 bingo card www.sfgate.com/business/art...

Imagine you're overseeing the termination of clinical trials, the destruction of people's livelihoods, the dismantling of scientific research in the US, and you're complaining that Twitter didn't give you a blue check 4 years ago.

We are excited to announce EchoPrime is published in Nature. EchoPrime is the first echocardiography AI model capable of evaluating a full transthoracic echocardiogram study, identify the most relevant videos, and produce a comprehensive interpretation!

After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership. My latest JACC Editor’s Page: The Partnership 🔗 www.jacc.org/doi/10.1016/... #MedTwitter #AcademicMedicine #Cardiology

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

🚨 #AI-based #ECG analysis significantly improved #STEMI detection, reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways. https://bit.ly/4hopPpT #TCT2025 #JACCINT #CardioSky

New event at #AHA2025! GPM Symposium Model Systems: Preclinical to Phase I Bridge Nov 7 12:30-5:15 Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

🎯 www.nature.com/articles/s41...

Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.

ENDORSE! Please can we make MOC make sense?

We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 . med.stanford.edu/hypertension/e… -Jehan Zahid Bahrainwala HTN Fellowship Program Director

Quality measurement was once a breakthrough. But today it’s too slow, too costly, and too disconnected from daily care. It’s time to reinvent it. 🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10.... @jaccjournals.bsky.social @yalemed.bsky.social

Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!! www.nytimes.com/2025/09/11/h...

I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics www.embopress.org/doi/full/10....

Promoting fads and infusing more money into the >$6 trillion wellness industry is not how to make America healthy. www.nytimes.com/2025/09/10/o...

I’m hiring in statistical genetics—senior scientist role but it’s the skills that matter—so earlier career folks with the right experience & interest should apply! There may also be multiple positions — so please RT & share w/ your network cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...

New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com! Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on?? jamanetwork.com/journals/jam...

Jay will be remembered for crying, "Censorship!" when the science community rejected his unfounded claims, gaining power by bowing to Trump, and then leading the most insane scientific censorship campaign in US history. www.wsj.com/health/scien...

The people dominating our political landscape, culture, and economy are just so stupid and full of shit it's almost impossible to describe

Some debates will never die www.nejm.org/doi/full/10....

Good lord, no. Why, people, why?? www.wsj.com/health/welln...

We all know exactly how this happened. www.theverge.com/news/756444/...