How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

🚨 #AI-based #ECG analysis significantly improved #STEMI detection, reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways. https://bit.ly/4hopPpT #TCT2025 #JACCINT #CardioSky

New event at #AHA2025! GPM Symposium Model Systems: Preclinical to Phase I Bridge Nov 7 12:30-5:15 Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

🎯 www.nature.com/articles/s41...

Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.

ENDORSE! Please can we make MOC make sense?

We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 . med.stanford.edu/hypertension/e… -Jehan Zahid Bahrainwala HTN Fellowship Program Director

Quality measurement was once a breakthrough. But today it’s too slow, too costly, and too disconnected from daily care. It’s time to reinvent it. 🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10.... @jaccjournals.bsky.social @yalemed.bsky.social

Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!! www.nytimes.com/2025/09/11/h...

I am tremendously excited to share our work revealing the epigenomic landscape of single vascular cells. We discover that enhancers are not only cell type but vascular site specific and regulate the genetic drivers of disease risk. Let's dive in! 🧬👇 #epigenetics www.embopress.org/doi/full/10....

Promoting fads and infusing more money into the >$6 trillion wellness industry is not how to make America healthy. www.nytimes.com/2025/09/10/o...

I’m hiring in statistical genetics—senior scientist role but it’s the skills that matter—so earlier career folks with the right experience & interest should apply! There may also be multiple positions — so please RT & share w/ your network cytokinetics.wd1.myworkdayjobs.com/en-US/Cytoki...

New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com! Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on?? jamanetwork.com/journals/jam...

Jay will be remembered for crying, "Censorship!" when the science community rejected his unfounded claims, gaining power by bowing to Trump, and then leading the most insane scientific censorship campaign in US history. www.wsj.com/health/scien...

The people dominating our political landscape, culture, and economy are just so stupid and full of shit it's almost impossible to describe

Some debates will never die www.nejm.org/doi/full/10....

Good lord, no. Why, people, why?? www.wsj.com/health/welln...

We all know exactly how this happened. www.theverge.com/news/756444/...

I’m not gonna QT the article baiting engagement but more posting doesn’t make a place great. Maybe people grew up & stopped wasting their time on debate bros, social media norms moved from conversation to broadcast, many explanations for fewer posts besides “people don’t actually like the platform”

100% the absolute wrong interpretation of these observations. I thought economists were supposed to understand confounding and causal inference 🤦🏻‍♂️. People do not randomly move between institutions.

Science. We had a good run...

IYKYK

David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...

Really really saddened to hear of Dr. Atul Butte's passing. Atul was a passionate scientist and mentor. When I was an undergrad, he took me for coffee, and his infectious enthusiasm completely changed my trajectory. I have always and will always look up to him.

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9

My favorite meeting to attend each year! Looking forward to these debates!

Stupid stupid stupid people. AI tech bros are the worst people to lead anything. They do not read. They do not check their work. They do not understand the tasks. They have complete faith in tools that repeatedly fail. www.propublica.org/article/trum...

DOGE is now reviewing every NIH grant that goes out, I reported last week. That review is AI-driven and is screening for DEI, trans health, China, vaccine hesitancy, and the institutions to whom Trump has blocked funding, @hannahnatanson.bsky.social reports. Gift link: wapo.st/3HhnPSt

i have said this before but this is why it was and is important not to ignore the “NPC” language. these people really believe that other human beings are not real, with all the consequences that flow from this

The NIH represents incredible value for the US economy and for the people of the world. We need to safeguard its future and that of our students and trainees. @rachelkeranen.bsky.social and I share our thoughts in today’s LA Times. www.latimes.com/opinion/stor...

Huge thanks to @kcklatt.bsky.social for having us on the AJCN 🎙️ to chat about the FeGenes study! Stay tuned for our next paper on the genetics of Fe absorption in this cohort, in collaboration with @yekaixiong.bsky.social. Exciting steps towards precision nutrition! open.spotify.com/episode/091s...

I helped draft this open letter about last Friday’s gold standard science executive order. Take a look and consider signing if you agree.

I subscribe to the @newyorker.com, I was part of ACT UP, I knew Larry Kramer well and know Tony Fauci too. Daniel Immerwahr's piece on RFKJr, features this and other passages that need a reponse. 1/

I disagree with Steven Pinker on nearly everything. But I agree with him on this. www.nytimes.com/2025/05/23/o...

Transthyretin cardiac amyloidosis is a disease caused by abnormal protein accumulation in the heart, in many regions the disease is often underdiagnosed. @stanfordmedicine.bsky.social @stanforddeptmed.bsky.social Read about the study here: med.stanford.edu/cvi/mission/...

You are not alone in this NIH grant game drugmonkey.wordpress.com/2025/05/21/y...

A US judge to govt lawyers defending the NIH's grant terminations: "I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition. This is research to advance healthcare for all our citizens."

Truly horrendous. Yet another way #UnitedHealth is an evil company. www.theguardian.com/us-news/2025...

Jay Bhattacharya's NIH is effectively being run by DOGE. www.nature.com/articles/d41...

It's only a matter of time before someone tries to publish a GWAS of vibes... www.biorxiv.org/content/10.1...

Individuals with inflammatory diseases benefit from LDL-C reduction even more so than those without. Compelling evidence from FOURIER for a clinically meaningful interaction between inflammation & LDL-C on atherosclerotic outcomes. www.ahajournals.org/doi/full/10....

Phenomenal work by @kiranmusunuru.bsky.social www.nytimes.com/2025/05/15/h...

Here's the point: this time Musk's engineers screwed up and revealed the disinformation operation. What about all the times people don't get caught? So long as LLMs are black boxes in the control of billionaires, we can't let LLMs become trusted information sources.

As we reported earlier today, this contest has become a venu for foreign business players to try to influence President Trump. Paying money to his family to get access to POTUS. It is yet another boundary breaking, conflict of interest for Trump, as we have documented...https://nyti.ms/4kkv7D7

Sephiroth is our next Surgeon General. www.motherjones.com/politics/202...

Lp(a) & recurrent atherosclerotic CV events: US Family Heart Database #CardioSky academic.oup.com/eurheartj/ad... @hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social

We've come a long way. 6 mo ago, there was almost no activity on #CardioSky. Now, all societies/journals are here & posting on 🦋, & we have a large group of #CardioSky users. We ALL need to be ACTIVE #SoMe users & contribute to this community by posting original material & reposting relevant content

One of grants frozen at Cornell: $6.7M (4 yrs) to develop heart pumps for babies born w/ heart defects. It took decades of work to get to point of prepping device for in-human clinical trials. No private company could do this. The cruelty of the Trump administration is heartbreaking. So to speak.