Do clinical trials expire? New heart attack studies show that evidence from 1980s may not apply to patients in 2025. Beta blockers are a case study in how medicine evolves, and how slowly our evidence base often keeps up. My latest Substack: neverdelegateunderstanding.substack.com/p/do-clinica...

After two years and thousands of manuscripts, I’ve learned that the real work of an editor isn’t gatekeeping — it’s partnership. My latest JACC Editor’s Page: The Partnership 🔗 www.jacc.org/doi/10.1016/... #MedTwitter #AcademicMedicine #Cardiology

After decades of disappointment in HFpEF, a new idea is shaking things up. Could heart failure with preserved EF actually be an adipose-driven disease? JACC’s latest issue explores “The Adipokine Hypothesis.” @jaccjournals.bsky.social 🔗 www.jacc.org/toc/jacc/cur...

Physician certification should not be an ordeal; it is in vast need of improvement. My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective. 🔗 www.jacc.org/doi/10.1016/...

In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing—if they fully own what they submit. At JACC, we won’t stigmatize responsible use of AI. But we will insist on accountability. jacc.org/doi/10.1016/... @jaccjournals.bsky.social

In this Editor’s Page, I outline why we believe authors can use AI tools to improve scientific writing if they fully own what they submit. At JACC,we won’t stigmatize responsible use of AI. We will insist on accountability. www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social @yalemed.bsky.social

For anyone who has wanted a clear, authoritative summary of inflammation and cardiovascular disease, and where the science is heading, here it is. The 2025 ACC Scientific Statement on Inflammation and Cardiovascular Disease. @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...

This is an extraordinary report from @ihmeuw.bsky.social and published in @jaccjournals.bsky.social; it demonstrates that cardiovascular disease is a global scourge. And we are failing to leverage what we know to save lives. www.jacc.org/doi/10.1016/...

Congratulations to @uvmlarnermed.bsky.social medical student, Sarah Krumholz, for winning the Outstanding Research Publication award for her study in REGARDS investigating risk of hypertension by sRAGE level! Very well deserved! Her paper: pubmed.ncbi.nlm.nih.gov/40708351/

Quality measurement was once a breakthrough. But today it’s too slow, too costly, and too disconnected from daily care. It’s time to reinvent it. 🆕 My Editor’s Page in JACC: www.jacc.org/doi/epdf/10.... @jaccjournals.bsky.social @yalemed.bsky.social

“Everyone thinks their genes are the cause for them getting an age-related disease, it’s actually your immune system.” - @erictopol.bsky.social the author of Super Agers on #HealthandVeritas podcast pod.link/1588414491/e... @thehowie.bsky.social @hmkyale.bsky.social

A conversation on Healthy Aging with @hmkyale.bsky.social and @thehowie.bsky.social @yaleschoolofmed.bsky.social insights.som.yale.edu/podcasts/hea...

New @JACCJournals: Guiding the AI Revolution in CV Medicine I lay out 5 operational principles—from rigorous validation to bias reduction—to make AI safe, equitable & impactful in cardiology. ➡️ www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social @yalemed.bsky.social @yaleschoolofmed.bsky.social

Biology, not blame. That’s the message from #ESCCongress. Fat is not just storage, it’s an organ. Its signals may drive heart failure and more. Read my take: Fat, Reframed: A Turning Point in Heart Disease. substack.com/home/post/p-... @jaccjournals.bsky.social @yaleschoolofmed.bsky.social

1/4 Rehabilitation can ⬆️ Functional Independence and ⬇️ Long-term Cognitive Impairment among #ICU survivors. But how often do hospitals deliver it? Led by @yalemedicine.bsky.social resident Jose Victor, our paper bit.ly/41p9fPT in @accpchest.bsky.social provides insights

New @JACCJournals Editor’s Page: A Disquieting Plateau 🫀 Cardiovascular mortality progress has stalled 📉 In some areas, it’s reversing 💡 We must confront what’s happening on our watch—and what comes next 👉 authors.elsevier.com/a/1lfjn2d9GI... #CardioTwitter #HealthEquity @jaccjournals.bsky.social

In my new Substack post... Did you know air pollution can raise blood pressure? I break down a just-published JACC trial testing HEPA filters in homes near highways—and what it means for heart health. @jaccjournals.bsky.social 👉 neverdelegateunderstanding.substack.com/p/00314b6f-e...

Can a HEPA filter protect the heart? My latest JACC #DeepDive explores a new trial of in-home air filtration—what it found, why the effect size matters, and how it fits into decades of research on air pollution and CVD risk. 🎧 www.jacc.org/digital-cont... @jaccjournals.bsky.social

🎙️ New JACC This Week podcast! This issue features: 🔹 CSPACE RCT — CSP vs RV pacing in AV block 🔹 HEPA filtration & blood pressure 🔹 FLAVOUR 6-year follow-up—FFR vs IVUS 🔹 Editor’s Page: excess CV mortality in Black Americans 🎧 Listen: www.jacc.org/digital-cont... @jaccjournals.bsky.social

Did COVID-19 really age our arteries? A major new study says yes—esp in women. But is it true? I take a deeper look to see if the evidence matches the headlines. Read it here → neverdelegateunderstanding.substack.com/p/did-covid-... #COVID19 @virusesimmunity.bsky.social @yalemed.bsky.social

“Never delegate understanding.” That quote stuck with me—and it’s now the title of my new Substack. I’ll be writing about health, science, & how these things can be understandable. Subscribe here → neverdelegateunderstanding.substack.com/subscribe #health #science #medicine @yalemed.bsky.social

🎙️ New #JACC Deep Dive MASTER DAPT recurrent events analysis goes beyond the first event, revealing total burden of ischemia & bleeding in PCI patients. Why we published it, what we learned, & how it changes the view. 🎧 Listen: www.jacc.org/digital-cont... #CardioTwitter #DAPT #HBR #PCI

From device safety to novel valve design—the new JACC This Week podcast covers: 🔹 Clinician-led device safety 🔹 MASTER DAPT recurrent events 🔹 Drug-coated balloons for complex ISR 🔹 Polymer surgical mitral valve Listen: bit.ly/4ove0Bn #JACCPodcast #Cardiology @jaccjournals.bsky.social

🎙️ New JACC This Week: 🧬 Mini-Focus on Amyloid Heart Disease 🫀 Vutrisiran echo + biomarker insights ✍️ Editor’s Page on access + innovation 🩼 Bonus: VVS trial + DOACs in frailty Listen now ⤵️ 🔗 www.jacc.org/digital-cont... @jaccjournals.bsky.social #cardiotwitter #amyloidosis

We’re drowning in data, but are we helping patients? In this #JACC Editor’s Page, Dr. @hmkyale.bsky.social challenges us to ask better questions in #HeartFailure care. If you think you know HF, read this: www.jacc.org/doi/10.1016/... #CardioSky #MedSky

🎧 New JACC This Week podcast: • SOGALDI-PEF: Dual therapy in HFpEF—worth it? • HFimpEF: Big data, big risk • Finerenone withdrawal • LMNA stroke risk • DSP & sex-specific risk • Rethinking ICDs 🎙️ Listen: www.jacc.org/digital-cont... #CardioTwitter @jaccjournals.bsky.social

🎙️ New JACC Deep Dive: Why did ACURATE neo2 fail in the IDE trial? Post hoc analysis suggests valve underexpansion may be part of the answer. Even with normal gradients. Even with a good echo. We explore what happened—and what’s next. 🔗 www.jacc.org/digital-cont... @jaccjournals.bsky.social

🎧 New #JACC This Week podcast 🔬 Valve underexpansion & outcomes in ACURATE IDE 💉 Body composition & tirzepatide in HFpEF 🏥 Private equity & heart failure care 🫀 Multivalve disease challenges 🧾 Brief reports+more ▶️ Listen: www.jacc.org/digital-cont... #cardiotwitter @jaccjournals.bsky.social

🎙️New Health & Veritas: A Visit from Your Local Epidemiologist We talk w/@kkjetelina.bsky.social about: • Building trust in public health • Making science clear—not scary • What’s next for COVID, H5N1, measles & more @yalesph.bsky.social @yalesom.bsky.social @thehowie.bsky.social

New Health & Veritas drops tomorrow! We’re joined by the incredible @kkjetelina.bsky.social — epidemiologist, communicator, & author of Your Local Epidemiologist. We talk public health, trust, & translating science for millions. @thehowie.bsky.social @yalesph.bsky.social @yalesom.bsky.social

“CV Prevention is in reach but only w/ implementation that’s global, upstream, and grounded in data.” In this week’s #JACCThisWeek, I highlight Focus Issue on Prevention: polypills, syndemics, PREVENT, inclisiran, and more. @jaccjournals.bsky.social 🎧 Listen here: www.jacc.org/digital-cont...

#JACC’s Guideline Spotlight debuts with the 2025 ACS Guideline 🚨 Featuring insights from Drs. Eugene Braunwald, Valentin Fuster, Robert M. Califf, & more—bold perspectives that inform, challenge & inspire Start browsing 👉 jacc.org/toc/jacc/85/... #cvACS #ClinicalGuidelines @hmkyale.bsky.social

The new #JACC spotlight issue flips the script: guidelines take center stage. Not an afterthought—this is the main event. Read why it matters 👉🔗 www.jacc.org/doi/10.1016/... #cvACS #ClinicalGuidelines @hmkyale.bsky.social

Using administrative claims and EHR databases rates of benign tumors and thyroid #cancer were not different in 460,032 users of GLP-1RAs vs. Users of other glucose lowering agents #diabetes @hmkyale.bsky.social diabetesjournals.org/care/article...

Great episode of Health & Veritas with Dr. Dave Chokshi! @hmkyale.bsky.social talks about his trip to China. I talk about helping to save 1 Million cases of congenital rubella syndrome over the next 30 years! insights.som.yale.edu/podcasts/hea...

“permissive firearm laws contributed to thousands of excess firearm deaths among children living in states with permissive policies” - the study by @jeremyfaust.bsky.social @mirandayaver.bsky.social @bhrenton.bsky.social @hmkyale.bsky.social et al (more tags!) in @jama.com Peds

Excited that my JAMA Pediatrics article with @jeremyfaust.bsky.social @bhrenton.bsky.social @hmkyale.bsky.social and others is now published. It turns out that permissive firearm laws aren’t great if you want to reduce pediatric firearm deaths. jamanetwork.com/journals/jam...

Our paper: since SCOTUS McDonald v. Chicago decision, states w/permissive firearm laws have had thousands of excess pediatric firearm deaths. 📊 6,029 excess deaths in the most permissive states 📈 Especially sharp rise among Black children 🔗 jamanetwork.com/journals/jam... @jeremyfaust.bsky.social

Lessons from Celect: What One Medical Device Taught Us About the Need for Transparency @jaccjournals.bsky.social 1/ In 2007, Celect IVC filter marketed as a safe way to prevent PE. By 2024: lawsuits, safety concerns, & calls for reform. Here’s what we can learn 👇 www.jacc.org/doi/full/10....

Important early study of #NIH research cuts by @hmkyale.bsky.social & colleagues in @jama.com. No grants administered by NIH Clinical Center or NCCIH were terminated; cumulative terminated grant funding=$1.81 billion, 30% of which had not been expended at termination jamanetwork.com/journals/jam...

New from @hmkyale.bsky.social, radical transparency on canceled #NIH grants. Largest number of terminated grants administered by Nat Inst of Mental Health (128) and Nat Inst on Minority Health and Health Disparities. #MedSky #PsychSky #politics #science

In divided times, #HealthCare must be more than a bystander. 🩺 #JACC Editor-in-Chief Dr. Harlan Krumholz, @hmkyale.bsky.social, calls on medicine to become a bridge, not a wall. Read why the time for courage is NOW: www.jacc.org/doi/10.1016/... #CardioSky #MedSky

I wrote this @jaccjournals.bsky.social because medicine should transcend borders & unite communities through shared purpose, evidence, and compassion. Words alone won’t change the world, but they can inspire actions and bring people together. www.jacc.org/doi/10.1016/... @yalemed.bsky.social

How to Lead a Chronic Disease Revolution. Proud to co-author this @wsj.com opinion piece with the incomparable @VirusesImmunity; we suggest that to make a dent in chronic disease, we should focus on post-infectious syndromes. @yalemed.bsky.social www.wsj.com/opinion/how-...

Trying something new: 🎙️ JACC Deep Dive: ~10 min podcast exploring topic/paper. Kicking off w/Altshock-2 trial (IABP in HF-related cardiogenic shock) + commentary on how the review unfolded. 🔗 www.jacc.org/digital-cont... Would love your feedback—keep going? @jaccjournals.bsky.social #Cardiology

New on @jaccjournals.bsky.social Deep Dive: Pulsed Field Ablation (PFA) for persistent AF is growing. I look into ADVANTAGE-AF trial, examining progress & work to be done. jacc.org/doi/10.1016/... 🎧 Listen now. Stay curious. jacc.org/digital-cont... #PFA #AtrialFibrillation #Cardiology

In Jan 2023, Damar Hamlin collapsed during NFL game & survived thanks to immediate CPR & AED use. But what do survival outcomes look like for young athletes across the U.S.? www.jacc.org/doi/10.1016/... New @jaccjournals.bsky.social Deep Dive episode explores the data. www.jacc.org/digital-cont...

Trying something new: 🎙️ JACC Deep Dive: ~10 min podcast exploring topic/paper. Kicking off w/Altshock-2 trial (IABP in HF-related cardiogenic shock) + commentary on how the review unfolded. 🔗 www.jacc.org/digital-cont... Would love your feedback—keep going? @jaccjournals.bsky.social #Cardiology

New @JACCJournals Editor’s Page: Black Lives, Cardiovascular Deaths Cardiovascular disparities cost Black Americans 23.7 million years of life from 2000–2022. 📖 authors.elsevier.com/a/1kwz92d9GI... #HealthEquity @YaleMed #Juneteenth #Cardiology

We were so happy to partner with participants on this decentralized, technology-enabled trial. Innovative way to do trials. I just wish the result had been better for patients. @VirusesImmunity @YaleMed @yalediscovers @TheLancetInfDis medicine.yale.edu/news-article...