💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment. #AHA25 @ahascience.bsky.social ja.ma/4p56SeB

Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A. #AHA25 @ahascience.bsky.social ja.ma/3JQSveI

November issue now live, with Reviews on: -Clonal haematopoiesis in cardiovascular disease -Regulators of cardiomyocyte proliferation -Extracellular vesicles in cardiovascular homeostasis and disease -Factor XI inhibitors for venous and arterial thromboembolism www.nature.com/nrcardio/vol...

In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M #ESCCongress #WCCardio #JACC

Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis. #ESCCongress #WCCardio ja.ma/45RBaJG

New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025 @jama.com jamanetwork.com/journals/jam...

The lab's first sim pub of #ESC2025 is now online in @jaccjournals.bsky.social #JACC! jacc.org/doi/10.1016/... Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study 👇 (1/X)

Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs Honigberg lab is rapidly growing 📈 👇 @mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social

Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center... @mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social

Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀 Please click on the event page to register & for all of the details! massgeneral.org/heart-center... @emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social

The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes journals.lww.com/greenjournal...

Missed the deadline? Plot twist: You didn't! Deadlines extended! 🗓️ #AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET. Award applications due 6/9 at 7pm ET. Submit here: 🔹 AHA: bit.ly/2025Extension 🔹 ReSS: bit.ly/ReSSExtension @ahascience.bsky.social #CardioSky

The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏 Basic & Translational category: Winner: Maria Pabon (BWH) Honorable Mention: Amelie Vromman (BWH) Clinical Research category: Winner: Meesha Vullikanti (Yale) Honorable Mention: Izza Shahid (Houston Methodist)

Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social

Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social

Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women #CardioObstetrics #CardioSky #JACC www.jacc.org/doi/10.1016/... @mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social

Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP) overall and across levels of HDP genetic risk www.jacc.org/doi/10.1016/... #CardioObstetrics #CardioSky

We love our team ❤️ Check out @mchonig.bsky.social's latest review!

Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social www.nature.com/articles/s41... Full text link: rdcu.be/ef9VW @mgbresearch.bsky.social @mgbwomenheart.bsky.social

Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social professional.heart.org/en/education...

Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️ @mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social

www.sciencedirect.com/science/arti... #CardioObstetrics

Getting ready for #ACC25? ✅ Download #ACC25 app apps.apple.com/us/app/acc-2... ✅ Follow #ACC25 ambassadors bsky.app/profile/did:... #CardioSky @accintouch.bsky.social @jaccjournals.bsky.social @saraersozlu.bsky.social @thornsberryjd.bsky.social @cathlabedu.bsky.social @bakhshihooman.bsky.social

Important trial of CAC scoring-guided CVD prevention (CAUGHT-CAD) out in @jama.com today: jamanetwork.com/journals/jam... In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y

Danish Analysis Updates Stroke and MI Risks of Contemporary Contraceptives

Guardian story about Federal Register issue is up. www.theguardian.com/us-news/2025...

Many of you may not be familiar with #NIH grants. Here are some facts to help you understand the magnitude of this disaster. 1) NIH grants are extremely difficult to get & not "free money". Researchers must have preliminary data & write detailed proposals. Mine was >200pages & took years to put

Government funds account for more than *half* the R&D budget that US universities spend each year—in 2023, that was $60B out of $109B. The gov also does a lot of its own research at national labs like Oak Ridge & Los Alamos and agencies like NOAA and DoD. What are the returns on that investment? 3/

The White House has ground NIH operations to a halt. E.g., the NHLBI’s CCHS study section, which evaluates large patient-oriented cardiovascular research proposals, was cancelled at the last minute this week. This is bad for science, scientists, patients/the public, and the economy.

Proud to be part of such an important Go Red for Women issue in @ahajournals.bsky.social re Hypertensive Disorders of Pregnancy from @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud! Congrats! @mgbwomenheart.bsky.social

Great in-depth review in this year's @ahajournals.bsky.social #Circulation Go Red for Women 💃 issue on HTN during & after 🤰 from the @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud 👇 www.ahajournals.org/doi/full/10....

Our team was honored to co-host Dr. Leslie Cho of the Cleveland Clinic at MGH Cardiology's Grand Rounds. Dr. Cho's topic was Sex Differences in Cardiovascular Disease @mdharringtonc.bsky.social @mchonig.bsky.social @emilyswlau.bsky.social @clevelandclinic.bsky.social

East & South Asian-Specific BP Trajectories & CVD #CardioSky #cvPrev #Hypertension www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @pnatarajanmd.bsky.social @mchonig.bsky.social @romitb.bsky.social @somijemmacho.bsky.social @psatishmd.bsky.social @drmonalidesai.bsky.social

What’s New in Cardiac Care for Pregnancy? See Who’s Speaking at CPP 2025! #CardioObstetrics #CardioSky #OBSky 🔗 cppcongress.com 🎙 @obcriticalcare.bsky.social @mchonig.bsky.social @drklindley.bsky.social @isabellemalhame.bsky.social @garimasharmamd.bsky.social @csilvers.bsky.social

Follow #CardioObstetrics community Let us know if anyone is missing from list #CardioSky #OBSky bsky.app/profile/did:...

Enjoyed writing this editorial with Jessica Faulkner on a really interesting paper by Maria Pabon and @mchonig.bsky.social on a role for METAP1 in preeclampsia. www.ahajournals.org/doi/10.1161/...

This study identifies METAP1 as a key gene linked to endothelial dysfunction in preeclampsia through transcriptomic profiling. by Pabon MA, Weisbrod RM (...) Honigberg MC et 23 al. in Circ Res #MedSky 📖 read the article: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.324606

In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia www.ahajournals.org/doi/10.1161/... #CardioObstetrics @mghcvrc.bsky.social

Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social

HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!! Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!

So so incredibly proud of 🇧🇪’s finest @artschuermans.bsky.social for this incredibly well-deserved recognition as the @ukbiobank.bsky.social Early Career Researcher of the Year for 2024! ⭐️ Lots of high-impact work so quickly - and lots more to come CC @broadinstitute.org @pnatarajanmd.bsky.social

Very nice summary of our study led by @artschuermans.bsky.social A. Pournamdari & with @mchonig.bsky.social www.massgeneralbrigham.org/en/about/new... @mgbresearch.bsky.social

New paper out in @ScienceMagazine! In 8 studies (multiple platforms, methods, time periods) we find: misinformation evokes more outrage than trustworthy news, when it does it's shared more + ppl are less likely to read before sharing. w/ @killianmcl1 @Klonick @mollycrockett 🧵👇

The power of proteomics Predicting cardiovascular outcomes www.nature.com/articles/s44...

Excited to share our latest in Nature Cardiovascular Research led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky Open access paper here: www.nature.com/articles/s44... Great thread from Art below 👇

What does the circulating proteome teach us about common heart diseases? Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions. Mentored (supremely) by @mchonig.bsky.social and @pnatarajanmd.bsky.social nature.com/articles/s44... (1/x)

Wow, how #cardiosky has grown! Our first starter pack is already full, see if you've missed anyone: go.bsky.app/562nfhZ

Maria Pabon of BWH cardiology presenting her work on biomarkers in 🤰 and postpartum cardiometabolic trajectories at #AHA24 #cardioobstetrics #cardiosky #medsky

Fantastic thought provoking cardiometabolic and 🫀 prevention research at this morning’s featured oral abstract session #AHA24 @ahascience.bsky.social #CardioSky #MedSky

Congratulations to these new FAHAs! 👏 🎉 🙌 Help us welcome them to the fam#AHA24#AHA24