A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR troponin T levels. What would you do next? ja.ma/4sxxvLB

RCT: Intracardiac echocardiography is non-inferior to transesophageal echocardiography for thromboembolic prevention in atrial fibrillation ablation, with added benefits in safety, efficiency, and patient comfort. ja.ma/4js7aKM

Low operator procedural volume for transcatheter aortic valve replacement and mitral transcatheter edge-to-edge repair was associated with increased 30-day procedural complications and adverse composite outcomes. ja.ma/49ms1uh

Monthly subcutaneous SHR-1918, a fully human monoclonal antibody targeting ANGPTL3, was associated with reduced LDL-C in adults with homozygous familial #hypercholesterolemia on stable lipid-lowering therapy. ja.ma/3LpfVbO

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered within 3 days and remained stable at 10-year follow-up. ja.ma/3MVV4xt

Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women. ja.ma/49rqjIe

In the Sarcomeric Human Cardiomyopathy Registry, lower household income and higher social deprivation index were each associated with higher rates of heart failure, arrhythmias, and mortality in #HypertrophicCardiomyopathy. ja.ma/45H74ZX

Among patients with #AtrialFibrillation, elevated BMI, and 1 or more additional cardiometabolic risk factors, aggressive risk factor management reduced arrhythmia recurrence over the 12-month period after catheter ablation. ja.ma/4snlYOX

From @jama.com: Among older adults with suspected lower extremity deep vein thrombosis (DVT), an age-adjusted D-dimer cutoff safely increased the proportion of individuals who could be ruled out for DVT without additional imaging. ja.ma/3YqfYY4

#Semaglutide consistently lowered hospitalization rates and hospital days in high-risk adults with #obesity and cardiovascular disease, with effects observed across clinical subgroups. ja.ma/49b62q0

Initial testing choice between coronary CTA and stress testing for suspected CAD showed no difference in all-cause or cardiovascular mortality among patients with stable symptoms. ja.ma/3LdrnaE

Integrating common, rare, and somatic genetic variants with clinical factors improves risk prediction for incident atrial fibrillation, aiding screening and prevention efforts. ja.ma/4q2SPaj

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. ja.ma/3YgnOTZ

#Semaglutide consistently lowered hospitalization rates and hospital days in high-risk adults with #obesity and cardiovascular disease, with effects observed across clinical subgroups. ja.ma/4pf47Xx

Papillary muscle scarring detected by dark blood MRI in dilated cardiomyopathy patients was independently associated with increased cardiac death, heart failure events, and arrhythmia, offering additional prognostic value. ja.ma/4bbB180

RCT: Intracardiac echocardiography is non-inferior to transesophageal echocardiography for thromboembolic prevention in atrial fibrillation ablation, with added benefits in safety, efficiency, and patient comfort. ja.ma/3MU7jKS

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered within 3 days and remained stable at 10-year follow-up. ja.ma/3LmCOwD

The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree? 🔗 ja.ma/49sdM8w

#Semaglutide consistently lowered hospitalization rates and hospital days in high-risk adults with #obesity and cardiovascular disease, with effects observed across clinical subgroups. ja.ma/3LdVyhO

Polygenic scores for hypertrophic and dilated cardiomyopathies independently and oppositely modified disease risk and penetrance of pathogenic variants, supporting bidirectional genetic influences on #Cardiomyopathy. ja.ma/4jam5Jx

The numbers are in. The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree? 🔗 ja.ma/48TWLUw

Small-interfering RNA olpasiran reduced lipoprotein(a)–apolipoprotein B particles by >95% with minimal rise in non–Lp(a)-apoB, lowering total apoB concentration in patients with cardiovascular disease. ja.ma/493ioQZ

Newborn screening using LDL-C and apolipoprotein B, followed by genetic testing, may substantially improve early diagnosis of familial hypercholesterolemia, a treatable genetic condition. ja.ma/4s4AnPO

In this subanalysis of the ARTESiA RCT, apixaban increased the risk of major gastrointestinal bleeding compared to aspirin in patients with subclinical atrial fibrillation (SCAF), but fatal and intracranial bleeding rates were similar. ja.ma/4jaQtn1

Among patients with #AtrialFibrillation, elevated BMI, and 1 or more additional cardiometabolic risk factors, aggressive risk factor management reduced arrhythmia recurrence over the 12-month period after catheter ablation. ja.ma/4p7sZR8

Changing from high-sensitivity cardiac troponin I to T assay doubled myocardial injury detection and admissions, without improving 1-year cardiovascular outcomes in suspected #AcuteCoronarySyndrome. ja.ma/4s2tr5J

Women with preeclampsia, other hypertensive disorders, large for gestational age, preterm delivery, or gestational diabetes were linked to increased long-term risk of atrial fibrillation. ja.ma/4s59smT

This narrative review describes current guidelines for intervention in severe primary #MitralRegurgitation and explores an approach that incorporates additional injury assessment, novel imaging markers, and biomarkers to optimize surgical timing. ja.ma/3ME5DVI

Intensive lipid-lowering therapy and lower on-treatment LDL-C were associated with less neoatherosclerosis and reduced late stent failure risk after #PCI for STEMI. ja.ma/4qbqONb

Editorial: Nonoptimal temperatures—both extreme heat and cold—pose major risks for cardiovascular events and mortality worldwide, with climate change intensifying temperature extremes and their health impacts. ja.ma/4s0soDi

Short-term exposure to both low and high temperatures was associated with increased all-cause and CVD mortality risk among patients with heart failure in Sweden. ja.ma/4pPSesf

Papillary muscle scarring detected by dark blood MRI in dilated cardiomyopathy patients was independently associated with increased cardiac death, heart failure events, and arrhythmia, offering additional prognostic value. ja.ma/48P3GNp

💬 Editorial: New analysis from the ASPREE trial suggests clonal hematopoiesis of indeterminate potential (CHIP) is linked to increased bleeding risk but not major cardiovascular events in healthy older adults. ja.ma/4rUxRLP

In older adults, CHIP was not linked to higher cardiovascular risk but was associated with increased clinically significant bleeding, and aspirin’s effects on CVD and bleeding did not differ based on CHIP presence. ja.ma/48M35fr

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered within 3 days and remained stable at 10-year follow-up. ja.ma/499NKGQ

RCT: Intracardiac echocardiography is non-inferior to transesophageal echocardiography for thromboembolic prevention in atrial fibrillation ablation, with added benefits in safety, efficiency, and patient comfort. ja.ma/4iV1Xe3

📢 This Special Communication describes the ZEUS trial, which will determine whether interleukin-6 inhibition with ziltivekimab reduces heart and kidney events in patients with atherosclerotic disease, chronic kidney disease, and systemic inflammation. ja.ma/3MEZJDz

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered within 3 days and remained stable at 10-year follow-up. ja.ma/48xaYXp

Integrating common, rare, and somatic genetic variants with clinical factors improves risk prediction for incident atrial fibrillation, aiding screening and prevention efforts. ja.ma/48MIA26

🎧 Listen to Alfred E. Buxton, MD, and @MarieF_Poulin, MD, discuss their article "Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement: Cardiac Conduction After TAVRt," with @rhythmkris, MD. ja.ma/4iK0rLI

💬 Editors Note: Many post-TAVR conduction abnormalities resolve quickly and do not predict delayed heart block, suggesting routine permanent pacemaker implantation is often unnecessary. ja.ma/4iK69xg

Among 409 patients undergoing transcatheter aortic valve replacement, intraprocedural block occurred in the atrioventricular node or His bundle, with site-specific predictors for intraprocedural and delayed heart block. ja.ma/3XLycmj

RCT: Among patients with obstructive prosthetic heart valve thrombosis, tenecteplase achieved higher complete thrombolytic success (97.5%) than alteplase (81.5%) and a shorter hospital stay. ja.ma/3XgMYBo

In this secondary analysis of the AZALEA-TIMI 71 RCT, abelacimab consistently reduced the risk of bleeding relative to rivaroxaban irrespective of kidney function. ja.ma/4pA6ViK

Editorial: The DANFLU-2 trial demonstrated that high-dose influenza vaccines have minor clinical advantages over standard-dose ones, highlighting the need for a health system focused on evidence rather than financial incentives. ja.ma/4oiPphN

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/48thQnp

Among older adults, high-dose influenza vaccine modestly reduced cardiorespiratory and cardiovascular hospitalizations compared to standard-dose vaccine, finds this secondary analysis of the DANFLU-2 randomized clinical trial. ja.ma/4agofVp

Among patients with severe symptomatic aortic stenosis at low to intermediate surgical risk, transcatheter aortic valve implantation was associated with a lower 1-year risk of all-cause death or any stroke. ja.ma/4onyiLV

💬 Viewpoint: RCTs in tricuspid regurgitation indicate that transcatheter therapies can enhance quality of life and reduce certain clinical events compared to medical therapy. ja.ma/49BoES7

On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/3M3eDmX