Editorial: Microaxial flow pump therapy may be most beneficial for myocardial infarction patients with cardiogenic shock experiencing severe hypotension despite vasopressor use. ja.ma/487BtB1

This post hoc analysis of the DanGer Shock RCT suggests that microaxial flow pump treatment may improve survival in patients with STEMI-related cardiogenic shock and profound systolic hypotension. ja.ma/4rdCDUn

Editorial: Schuermans et al's study links clonal hematopoiesis (CHIP) to acute inflammatory heart conditions, suggesting that CHIP mutations could serve as key biomarkers for predisposition to chronic and acute cardiac diseases. ja.ma/3KcEvfu

Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis. ja.ma/48mee7I

Editor's Note: Herraiz-Adillo et al report that stage 2 hypertension and even modestly increased systolic blood pressure in young adulthood are independently associated with severe coronary stenosis in midlife. ja.ma/4pgDK3V

In this population-based cohort study, higher BP levels in adolescence were associated with a dose-dependent higher risk for atherosclerosis in middle age, particularly for severe coronary atherosclerosis. ja.ma/4oZ8cja

In older patients with myocardial infarction and multivessel disease, physiology-guided complete revascularization achieved a sustained reduction in adverse outcomes compared to culprit-only treatment over a 3-year follow-up period. ja.ma/43yOORC

In patients with myotonic dystrophy type 1, electrophysiological measurement of the His-ventricular interval is more sensitive and accurate than ECG criteria for identifying those at risk for major bradyarrhythmic events and in need of prophylactic pacing. ja.ma/485r8WB

A previously healthy 55-year-old man presented to his local family medicine clinic after waking up with a buzzing sensation in his chest. What would you do next? ja.ma/46xum4h

In a national US analysis of TAVR procedures from 2012 to 2024, annual volumes of redo TAVR and TAVR explant increased, TAVR reintervention beyond 5 years is predominantly performed via redo TAVR. ja.ma/4gzabHE

An AI-ECG risk model demonstrated superior prediction of incident complete heart block within 1 year compared to traditional markers. ja.ma/4nSUb5p

In a binational study of older adults with diabetes, nearly 60% in the US and 31% in Japan discontinued #GLP-1RAs within 12 months of starting injectable #semaglutide. ja.ma/4mtbvxe

In patients with myotonic dystrophy type 1, electrophysiological measurement of the His-ventricular interval is more sensitive and accurate than ECG criteria for identifying those at risk for major bradyarrhythmic events and in need of prophylactic pacing. ja.ma/4nI0QzJ

💬 Editorial: Guideline-directed medical therapy and structured plaque assessment may advance prevention for patients with nonobstructive, high-risk carotid plaques. ja.ma/4qQJ4Nf

In this subanalysis of the ARTESiA RCT, apixaban increased the risk of major gastrointestinal bleeding compared to aspirin in patients with subclinical atrial fibrillation (SCAF), but fatal and intracranial bleeding rates were similar. ja.ma/4oxznBx

Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A. ja.ma/4qK5nnw

Moderate to vigorous physical activity in guideline-recommended ranges was associated with lower risk of adverse cardiovascular outcomes and did not increase arrhythmia risk or pathologic cardiac remodeling in G+P− carriers. ja.ma/498Jwjp

Pretreatment with atorvastatin during anthracycline chemotherapy was associated with preserved aortic vascular function in lymphoma patients, lowering odds of increased stiffness vs placebo. ja.ma/3LvUqG5

Acoramidis demonstrated equivalent benefit for mortality and cardiovascular hospitalization in wild-type and variant ATTR-CM, including p.Val142Ile, over 42 months of follow-up. ja.ma/3JTSjLO

From @jamanetworkopen.com: Among adults with symptoms after #COVID19 infection, a pragmatic, home-based resistance exercise program is a generalizable, safe, and effective therapy for improving physical and psychological function. #AHA25 @ahascience.bsky.social ja.ma/3XmnYZm

From @jamanetworkopen.com: For home health aides (HHAs) caring for adults with #HeartFailure (HF), HF training improved HHA knowledge and self-efficacy, with greatest gains among those with the lowest baseline scores. #AHA25 @ahascience.bsky.social ja.ma/47zLpoa

Editor’s Note: Prospective pilot data by Jain et al validate an #AI model for ATTR-CM screening; real-world implementation challenges and outcome effects require further study. #AHA25 @ahascience.bsky.social ja.ma/4oxBPrT

#AI model ATTRACTnet improved detection of undiagnosed ATTR-CM, with a >2.8-fold higher diagnostic yield vs historical controls and increased system-wide case identification. #AHA25 @ahascience.bsky.social ja.ma/3WLzv4g

In this #AHA25 edition of the JAMA Editor’s Summary podcast, Gregory Curfman, MD, Philip Greenland, MD, and Robert Bonow, MD, MS, review key JAMA Network articles, including: ➡️ Coffee and #AFib, ➡️ DASH-patterned groceries, ➡️ Oral PCSK9 inhibitor enlicitide, and more. 🎧 Listen now: ja.ma/47MpAAj

💾 Save this thread! Check out these key findings from today's JAMA, @jamacardiology.com, @jamainternalmed.com, and @jamanetworkopen.com presentations at #AHA25. 🧵 Adding coronary CT angiography to traditional risk scores modestly improved prediction of first coronary events. ja.ma/4oyzvko

Robert Bonow, MD, MS, is celebrated at #AHA25. Dr Bonow, founding editor of JAMA Cardiology, marked 10 years as its Editor in Chief.

💬 Editorial from @jama.com: While early detection and treatment may help some high-risk youth, the study by Bellows et al suggests broader population approaches to lower LDL-C distribution may provide greater cost-effectiveness. #AHA25 @ahascience.bsky.social ja.ma/4owIqCV

From @jama.com: Sequential childhood or early adulthood screening for familial hypercholesterolemia may lower lifetime CVD risk, but is unlikely to be cost-effective unless follow-up for elevated cholesterol is widely implemented. #AHA25 @ahascience.bsky.social ja.ma/3WKUmEM

From @jamainternalmed.com: A 6-month habit-based group lifestyle intervention added to routine education and activity monitoring improved the proportion of patients with sustained metabolic syndrome remission. #AHA25 @ahascience.bsky.social ja.ma/3LONdRu

💬 Editorial from @jama.com: The GoFresh trial showed home-delivered DASH groceries modestly lowered BP and LDL cholesterol in Black adults, but high costs and diet design limit broader impact. #AHA25 @ahascience.bsky.social ja.ma/4nKFu4m

From @jama.com: Home-delivered, low-sodium Dietary Approaches to Stop Hypertension (DASH) groceries and dietitian support temporarily improved blood pressure and LDL cholesterol in Black adults with high BP versus monetary support. #AHA25 @ahascience.bsky.social ja.ma/4hXIMA4

💬 Editorial from @jama.com: The CORALreef HeFH trial demonstrated that oral enlicitide achieves reductions in LDL-C and other atherogenic lipids in patients w/ heterozygous familial hypercholesterolemia receiving statin therapy. #AHA25 @ahascience.bsky.social ja.ma/4owIhiR

From @jama.com: Among adults with HeFH who were already taking statin therapy, treatment with enlicitide was well tolerated and reduced levels of LDL-C, apolipoprotein B, non–HDL-C, and lipoprotein(a). #AHA25 @ahascience.bsky.social ja.ma/4nLNvG6

From @jamanetworkopen.com: For neonates w/ congenital heart defects (CHDs) in Illinois, delayed #prenatal care initiation was associated with a higher probability of delivery at a pediatric #cardiac center, especially for severe CHD. #AHA25 @ahascience.bsky.social ja.ma/4nFWrNd

From @jama.com: Adding coronary CT angiography to traditional risk scores modestly improved prediction of first coronary events in a large population-based study. #AHA25 @ahascience.bsky.social ja.ma/4nO5Nqv

💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment. #AHA25 @ahascience.bsky.social ja.ma/4p56SeB

Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A. #AHA25 @ahascience.bsky.social ja.ma/3JQSveI

Meta-analysis from @jamanetworkopen.com: Compared to standard regimens, trastuzumab emtansine exhibited a more favorable cardiotoxicity profile, while other novel and standard therapies demonstrated comparable risks of LVEF decline. #AHA25 @ahascience.bsky.social ja.ma/47N3Gx9

A randomized clinical trial published in JAMA found that patients with AF who consumed caffeinated coffee had a lower risk of recurrent AF or atrial flutter compared with those who abstained. #AHA25 #AFib @ahascience.bsky.social ja.ma/49GpXPu

📊 Research Summary from @jama.com: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine. #AHA25 @ahascience.bsky.social ja.ma/47Nwy8q

From @jama.com: Patients with #AFib who continued their usual caffeinated coffee intake after cardioversion experienced less recurrence of AF or atrial flutter compared to those who abstained from coffee and caffeine. #AHA25 @ahascience.bsky.social ja.ma/3JA3f15

🧵 #AHA25 attendees, check out these key findings from today's JAMA and @jamacardiology.com presentations: Among people with PAD and no #diabetes, metformin treatment for 6 months did not result in improvements in walking ability or secondary outcomes vs placebo. ja.ma/4oqMJzr

💬 @jama.com Editorial: While restrictive transfusion remains standard, TOP trial results indicate some cardiac patients may benefit from a tailored approach based on clinical factors. #AHA25 @ahascience.bsky.social ja.ma/3JyJy9T

From @jama.com: Liberal transfusion after major surgery did not reduce death or major cardiac event rates compared to restrictive thresholds in high-risk patients. #AHA25 @ahascience.bsky.social ja.ma/3LrE15A

💬 Invited Commentary: Chronic kidney disease (#CKD) amplifies cardiovascular risk, yet therapeutic inertia and low disease awareness persist. New CKM syndrome data reveal persistently low CKD recognition. #AHA25 @ahascience.bsky.social ja.ma/4otDIWj

From 2011 to 2020, chronic kidney disease affected 14.6% of US adults and 16.7% with cardiometabolic conditions, yet only 13% were aware of their diagnosis; awareness was lowest in younger adults, women, and Hispanic adults. #AHA25 @ahascience.bsky.social ja.ma/4hXARmk

Moderate to vigorous physical activity in guideline-recommended ranges was associated with lower risk of adverse cardiovascular outcomes and did not increase arrhythmia risk or pathologic cardiac remodeling in G+P− carriers. #AHA25 @ahascience.bsky.social ja.ma/3XgCrG6

Pretreatment with atorvastatin during anthracycline chemotherapy was associated with preserved aortic vascular function in lymphoma patients, lowering odds of increased stiffness vs placebo. #AHA25 @ahascience.bsky.social ja.ma/3LsgFg6

From @jama.com: Among people with PAD and no #diabetes, metformin treatment for 6 months did not result in improvements in walking ability or secondary outcomes vs placebo. #AHA25 @ahascience.bsky.social ja.ma/4qNpDEV

Acoramidis demonstrated equivalent benefit for mortality and cardiovascular hospitalization in wild-type and variant ATTR-CM, including p.Val142Ile, over 42 months of follow-up. #AHA25 ja.ma/43gn0kT