At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy. ja.ma/4rK6Zhh

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy. ja.ma/4l5648D

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (<1%), while bleeding events occurred in 13% and were more frequent among women and those on long-term antithrombotic therapy. ja.ma/4l08bKY

From @jama.com: Among adults undergoing cardiac imaging for #CoronaryArteryDisease, radiation dose varied widely and was higher for CCTA in low-income countries. The findings suggest a need for standardized protocols to reduce exposure. ja.ma/4qTgSI0

From @jama.com: 📊 This Rational Clinical Examination evaluates the diagnostic accuracy of clinical examination, radiographic imaging, and laboratory testing in assessing volume overload in nonintubated patients. ja.ma/3N1rQNV

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women. ja.ma/3OFpMvo

Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women. ja.ma/4b1joax

Among men with localized #ProstateCancer, treatment with GnRH agonist leuprolide resulted in greater 12-month coronary plaque progression vs GnRH antagonist relugolix, driven by increased noncalcified plaque volume. ja.ma/4atENsT

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature #CardiovascularDisease. Pregnancy presents a key window for CV risk assessment and counseling. ja.ma/4tGF436

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women. ja.ma/4c5wWTt

Meta-analysis of four randomized trials found β-blockers did not reduce mortality, recurrent #MyocardialInfarction (MI), heart failure, or revascularization in patients with preserved left ventricular ejection fraction after MI. ja.ma/4act2FU

Among men with localized #ProstateCancer, treatment with GnRH agonist leuprolide resulted in greater 12-month coronary plaque progression vs GnRH antagonist relugolix, driven by increased noncalcified plaque volume. ja.ma/40ijMex

A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR troponin T levels. What would you do next? ja.ma/3ZN12Ue

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature #CardiovascularDisease. Pregnancy presents a key window for CV risk assessment and counseling. ja.ma/4kIcJWe

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women. ja.ma/3ZEhGFK

This narrative review describes current guidelines for intervention in severe primary #MitralRegurgitation and explores an approach that incorporates additional injury assessment, novel imaging markers, and biomarkers to optimize surgical timing. ja.ma/4r1dewT

Monthly subcutaneous SHR-1918, a fully human monoclonal antibody targeting ANGPTL3, was associated with reduced LDL-C in adults with homozygous familial #hypercholesterolemia on stable lipid-lowering therapy. ja.ma/4bAdazb

Changing from high-sensitivity cardiac troponin I to T assay doubled myocardial injury detection and admissions, without improving 1-year cardiovascular outcomes in suspected #AcuteCoronarySyndrome. ja.ma/4qcy37n

Among patients with diabetes and multivessel coronary artery disease, ticagrelor was not noninferior to prasugrel for reducing death, myocardial infarction, stroke, or major bleeding at 1 year after percutaneous coronary intervention. ja.ma/4cq43l2

Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women. ja.ma/4kcZFaW

In symptomatic patients without known coronary disease, #CCTA-derived plaque burden and volume independently predicted MACE beyond clinical risk and standard imaging findings. ja.ma/4tA9bcj

From @jama.com: The FDA recently cleared a new smartwatch #hypertension notification feature for the Apple Watch. In this study, researchers applied performance metrics to nationally representative US survey data to better understand the potential population impact. ja.ma/3MIBjJN

In the Sarcomeric Human Cardiomyopathy Registry, lower household income and higher social deprivation index were each associated with higher rates of heart failure, arrhythmias, and mortality in #HypertrophicCardiomyopathy. ja.ma/46i75nu

Among patients with supraventricular tachycardia, use of a handheld Valsalva assist device resulted in greater rates of sinus rhythm restoration compared with the standard Valsalva maneuver (63% vs 29% within 1 minute after up to two attempts). ja.ma/3MGZus7

#Semaglutide consistently lowered hospitalization rates and hospital days in high-risk adults with #obesity and cardiovascular disease, with effects observed across clinical subgroups. ja.ma/4qml4zX

Among patients with diabetes and multivessel coronary artery disease, ticagrelor was not noninferior to prasugrel for reducing death, myocardial infarction, stroke, or major bleeding at 1 year after percutaneous coronary intervention. ja.ma/4cn8Of5

Polygenic scores for hypertrophic and dilated cardiomyopathies independently and oppositely modified disease risk and penetrance of pathogenic variants, supporting bidirectional genetic influences on #Cardiomyopathy. ja.ma/4kmmb1k

In symptomatic patients without known coronary disease, #CCTA-derived plaque burden and volume independently predicted MACE beyond clinical risk and standard imaging findings. bit.ly/462BJBh

Intensive lipid-lowering therapy and lower on-treatment LDL-C were associated with less neoatherosclerosis and reduced late stent failure risk after #PCI for STEMI. ja.ma/3O804PX

💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment. ja.ma/4tmlWrc

Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A, supporting CHIP as a novel risk factor. ja.ma/4a01DIs

💬 Editor’s Note: Prospective pilot data by Jain et al validate an #AI model for ATTR-CM screening; real-world implementation challenges and outcome effects require further study. bit.ly/46EAGHV

#AI model ATTRACTnet improved detection of undiagnosed ATTR-CM, with a >2.8-fold higher diagnostic yield vs historical controls and increased system-wide case identification. ja.ma/46v8Cql

Among older patients with #AtrialFibrillation, abelacimab reduced major or clinically relevant bleeding vs rivaroxaban, with a greater absolute risk reduction in those aged ≥75 years. bit.ly/4alEy1P

For US adults eligible for secondary #CardiovascularDisease prevention, #Semaglutide would be cost-effective if annual drug cost is reduced by 18% to $7055 or if current cash price is widely available. bit.ly/4kiwH9H

💬 Editorial: Price reductions for #PCSK9 inhibitors and #Semaglutide substantially improved cost-effectiveness and access, highlighting the need for value-based drug pricing in cardiovascular care. ja.ma/4rpH3XC

RCT: Among patients with obstructive prosthetic heart valve thrombosis, tenecteplase achieved higher complete thrombolytic success (97.5%) than alteplase (81.5%) and a shorter hospital stay. ja.ma/49TTQMf

Analysis of NHANES data from 2021 to 2023 found that 79.1% of US adults with hypertension had blood pressure above the 2025 AHA/ACC goal of <130/80 mm Hg. ja.ma/4a0E0hm

Today we welcome Barbara Casadei, MD, DPhil, from @imperialnhli.bsky.social, as Editor in Chief. An internationally recognized clinician‑scientist, Dr Casadei brings extensive experience in global cardiovascular research. 🧵

Among older patients hospitalized for #HFrEF, prescription of quadruple medical therapy at discharge was associated w/ a 1-year mortality of 19% and heart failure rehospitalization rate of 26%, w/ median health care costs of nearly $28,000 per patient. ja.ma/4akLpJT

An estimated 148 million US adults meet FDA-approved indications for at least one #CKM therapy, including 11 million with eligibility for all three medication classes. ja.ma/4bXGUGo

JAMA Cardiology marks its 10th anniversary with gratitude to founding Editor in Chief Robert O. Bonow, MD, MS. In his farewell Editorial, Bonow reflects on building a top-cited cardiovascular journal: “It’s a very rare, once‑in‑a‑lifetime opportunity.” ja.ma/3NM60Ow

RCT: Among patients with obstructive prosthetic heart valve thrombosis, tenecteplase achieved higher complete thrombolytic success (97.5%) than alteplase (81.5%) and a shorter hospital stay. ja.ma/4rchHw8

Among older patients hospitalized for #HFrEF, prescription of quadruple medical therapy at discharge was associated with a 1-year mortality of 19% and heart failure rehospitalization rate of 26%, with median health care costs of nearly $28,000 per patient. ja.ma/4t1I8ql

💬 Invited Commentary: Chronic kidney disease (CKD) amplifies cardiovascular risk, yet therapeutic inertia and low disease awareness persist. New CKM syndrome data reveal persistently low CKD recognition. ja.ma/49PDh44

An estimated 148 million US adults meet FDA-approved indications for at least one #CKM therapy, including 11 million with eligibility for all three medication classes. ja.ma/49PWRM0

Chronic kidney disease affected 14.6% of US adults and 16.7% of those with cardiometabolic conditions, but only 13% were aware of their diagnosis, with lowest awareness among younger adults, women, and Hispanic adults. ja.ma/3NEEXVn

From @jama.com: In adults receiving heart transplants after donor circulatory death, rapid recovery with extended ultraoxygenated preservation enabled safe use of hearts from older donors and with longer ischemic times. ja.ma/4rjSQXE

💬 Viewpoint: RCTs in tricuspid regurgitation indicate that transcatheter therapies can enhance quality of life and reduce certain clinical events compared to medical therapy. ja.ma/46e4dIa

Pretreatment with atorvastatin during anthracycline chemotherapy was associated with preserved aortic vascular function in lymphoma patients, lowering odds of increased stiffness vs placebo. ja.ma/4qE3GHH