Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

‪The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!

👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries www.medrxiv.org/content/10.1...

📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference In-person registration closes Aug 19: https:/bit.ly/anvil2025

Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section! www.cell.com/ajhg/abstrac... elsihub.org/news-and-eve...

🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest! - Regular rate ($75): bit.ly/acc2025-register - Student rate ($25): bit.ly/acc2025-register-student - Virtual (free!): bit.ly/acc2025-register-virtual Don’t miss it!

🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏 See also our thread on the pre-print - bsky.app/profile/prsd...

ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social www.cell.com/ajhg/abstrac...

Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social! Genetic information can help improve risk prediction for a broad range of health outcomes. Learn more: 🧬 Publications: primedconsortium.org/publications... 🧬 Research Highlights: primedconsortium.org/research/hig...

I wrote a thing. I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach. Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/ www.sciencedirect.com/science/arti...

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

📣 Call for community feedback! The @prsdiversity.bsky.social is using @anvilproject.org for shared data storage and collaborative analysis in the cloud - see a list of our workflows: primedconsortium.org/research/ana...

Congratulations to @prsdiversity.bsky.social researchers @eimearekenny.bsky.social and @genandgenes.bsky.social, featured in @geneticssociety.bsky.social #WomensHistoryMonth

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

👀🔖 Curious how a research consortium manages sharing data to collaborate on improving genetic risk prediction in global populations? Check out this new preprint from the @prsdiversity.bsky.social data sharing working group! arxiv.org/abs/2502.09351 1/

So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social

📹🍿🧬 Check out @yunfeng-ruan.bsky.social's recent talk at the @broadinstitute.org, "Polygenic risk scores: method development and application" in our growing collection of videos on the @prsdiversity.bsky.social website primedconsortium.org/education#vi...

📣 👀 🧬 Join @prsdiversity.bsky.social and @geneticssociety.bsky.social tomorrow for a journal club on developing polygenic risk scores in diverse populations

We're delighted to have the @prsdiversity.bsky.social Perspective featured in the Genomics Landscape, the NHGRI Director's monthly newsletter, https://buff.ly/3PsUJjF. The Perspective outlines goals, approaches, and ongoing activities, including new PRS methods and models.

👀 📑 Join @prsdiversity.bsky.social investigators at the @geneticssociety.bsky.social January 15 journal club! Details and registration below👇

It’s out! New Hastings Center Special Report: Envisioning a More Just Genomics. 📣 👏 Read, bit.ly/40dX48h This special report is a collaboration between The Hastings Center and the Center for ELSI Resource and analysis (CERA) @elsihub.bsky.social #Bioethics #Genomics #Genetics

👀 📆 Mark your new 2025 calendars for the Jan 15 @geneticssociety.bsky.social journal club, where Iftikhar Kullo @mconomos.bsky.social and @blueyedgenes.bsky.social will present the PRIMED Perspective paper www.cell.com/ajhg/fulltex.... Register for free at learning.ashg.org/products/ove...

🎆 Ring in the new year by reviewing the PRIMED Consortium's progress on improving genetic risk prediction in diverse genetic ancestry populations. See our Research Highlights https://buff.ly/4iUpmfw and video collection https://buff.ly/4iKIbli

👀🎉 Check out our new PRIMED (Polygenic Risk Methods in Diverse Populations) Consortium starter pack! go.bsky.app/RFJRsTt

🎉 We'll look forward to adding Bluesky mentions to the next @altmetric.com report for all PRIMED Consortium publications, which we post on our website: primedconsortium.org/publications...

👀🔖 Thank you for this compilation @shaicarmi.bsky.social - the @prsdiversity.bsky.social consortium reviewed several PRS methods for diverse populations in this @naturerevgenet.bsky.social 2023 commentary led by @lindakachuri.bsky.social and Tian Ge, pubmed.ncbi.nlm.nih.gov/37620596/

Work by PhD student @jayatirsharma.bsky.social on how grouping Hispanic/Latino participants into a single group can obfuscate substantial substructure, leading to false conclusions. We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.

New preprint! Within the HCHS/SOL study, we looked at the roles of self-identified background and genetic ancestry in describing GxE interactions of a PGS and sociocultural variables in a Hispanic/Latino population. www.medrxiv.org/content/10.1...

If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after! cc @iamslambert.bsky.social

Hello Bluesky! The PRIMED Consortium is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations. Read more in our recently published Perspective 🧵 1/ www.cell.com/ajhg/fulltex...