Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

The INCEPTION is organizing its Annual Symposium. This year is about GWAS & beyond! We're happy to have @bpasaniuc.bsky.social, @caina89.bsky.social, Iuliana Ionita-Laza , Sriram Sankararaman, and others, who will talk about tools for understanding the genetic determinants of complex diseases

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791... You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

📣 We are recruiting! Please share!! Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺 We have two roles available 👇 🧵 1/4

We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: mostafavilab.org

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025. These things can take time and patience is key!

📢OUT TODAY @natgenet.nature.com 📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk. By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1

Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!

📣New from @bpasaniuc.bsky.social & co 📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations

Rivian just reported Q1 2025 earnings: - Second straight quarter of gross profit - R2 still on track for early 2026 - Hands-free driving rolling out - $1B from VW coming in June - Deliveries revised to 40k–46k for 2025 Full details: riviantrackr.com/news/rivian-...

Two more weeks to go! Inclusive Genomics to Promote Health Excellence Symposium at @upenn.edu @penngenetics.bsky.social @pennmedcso.bsky.social! Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/

Looking forward to presenting at the Cell Symposia: Precision genomics for human health in San Diego, September 11–13, 2025. For a chance to present your research at this event, submit an abstract before May 30 here: www.cell-symposia.com/precision-ge... #CSPrecisionGen25 See you in San Diego!

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

🚨 New paper 🚨 Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery? 🔍 10,960 people, 9 biobanks, 6 countries 🧬 Minimal genetic impact on GLP1-RA response 📉 Modest effect after surgery www.nature.com/articles/s41...

Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm! Submission deadline is June 8th, conference July 6-11th.

Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtv

“Investments in science and public health are essential for the future of rural southern states like Mississippi.” Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

WHAMM identified as key kidney disease risk gene ft. @DhanunjayMukhi, Lakshmi Kolligundla, @TomohitoD, @andradesilvamag, @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social), @Hongbo919Liu (@UR_Med) & Matthew Palmer (@pennpathlabmed.bsky.social) www.cell.com/cell-reports...

The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...

Register for the UPennn symposium on “Inclusive Genomics to Promote Health Excellence” organized by @sarahtishkoff.bsky.social and @bpasaniuc.bsky.social at the Center for Global Genomics & Health Equity and the Center for Computational Biomedicine. Link: upenn.co1.qualtrics.com/jfe/form/SV_...

Dr. Sarah Dry and Dr. Bogdan Pasaniuc gearing up for another path-packed day at #USCAP2025! Join us for UCLA Pathology's events today! Full Schedule ➨ bit.ly/4ccBkxZ #pathology #path2path #PathSky #Boston #GIpath #Genomics @bpasaniuc.bsky.social @uscap.org

Terrific speaker line-up covering a broad spectrum of biological questions addressed through a common language made of math, statistics and computer science #ai #computerscience #math #physics #complexsystem #evolution #machinelearning #statistics #popgen #genomics #proteomics Please re-post !

Proud to stand up for science on the steps of the Tennessee state capital in Nashville! #standupforscience

Tomorrow is the last day to apply to the Leena Peltonen School of Human Genomics summer program (Wellcome Campus, UK) for scientists nearing the completion of their PhD. 1:1 mentorship from many fantastic tutors! lpshg.com/how-to-apply/

Let's talk about this Nature piece in more detail. I've rarely read something so anti-scientific anywhere short of the National Review. www.nature.com/articles/d41...

New research out in @science.org from @hongbo919.bsky.social & @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social) provides a genetic map of kidney function & introduces a kidney multiome-based genetic scorecard for disease diagnostics & therapeutic development tinyurl.com/ubkutd4s

📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41... A comment @natrevgenet.bsky.social from @katholt.bsky.social and me

🎇Our new paper in @ScienceMagazine : Kidney Multiome-Based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants. @Hongbo919Liu science.org/doi/10.1126/...

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

They said it doesn’t snow that much in Philly!

Can we find epistasis in human traits? To help, in our preprint, we present the most scalable and powerful framework for detecting epistasis to date: the “sparse marginal epistasis test” (SME). Thank you @lcrawford.bsky.social, @sampatsmith.bsky.social, Dan Weinreich! doi.org/10.1101/2025... 1/6

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. https://ja.ma/3W8RykL

However, I did notice the possibility that some grad school applicants abuse bioRxiv by posting manuscripts that practically can't get through any serious peer review.

Excited to be part of 2025 Leena Peltonen School of Human Genomics! Great opportunity for trainees to interact 1:1 with established PIs including: @andganna.bsky.social @gosiatrynka.bsky.social @sashagusevposts.bsky.social and many more! July 27-31 Wellcome Genome Campus, UK. Apply at: lpshg.com

What do GWAS and rare variant burden tests discover, and why? Do these studies find the most IMPORTANT genes? If not, how DO they rank genes? Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬) www.biorxiv.org/content/10.1...

Really enjoyed doing this Q&A on complex traits, heritability, twins, and GWAS. Psychiatry At The Margins is a gem!

Exciting work by the great @ruthiejohnson.bsky.social !! 👏

👀🎉 Check out our new PRIMED (Polygenic Risk Methods in Diverse Populations) Consortium starter pack! go.bsky.app/RFJRsTt

This is going to save hospitals a lot of money ! www.pennmedicine.org/news/news-re...

The banality of racism. CEO of Orchid "..it’s super important. The pop. of all of the places we love is shrinking. In 50 years, 30 years, you’ll have half as many people in places that you love. Society will collapse" But pop. of Africa forecast to grow 60% in 25 years! www.wired.com/story/this-w...

Welcome to my new Bluesky account! 🌟 We’re dedicated to unlocking the mysteries of kidney disease using cutting-edge science. Join us on a journey of discovery as we share what we do, how we do it, and the resources available at susztaklab.com! 🧵👇

Is it Bad to leave Twitter? No. Here are 7+ years of insights from my lab’s research that explain why. Featuring work w/ @williambrady.bsky.social @killianmcloughlin.bsky.social 🧵