We have a new paper outlining the latest challenges and future directions for Mendelian randomization. We used AI to review 10,126 abstracts from studies using Mendelian randomization. www.nature.com/articles/s41...

JAMA Cardiology marks its 10th anniversary with gratitude to founding Editor in Chief Robert O. Bonow, MD, MS. In his farewell Editorial, Bonow reflects on building a top-cited cardiovascular journal: “It’s a very rare, once‑in‑a‑lifetime opportunity.” ja.ma/3NM60Ow

New event at #AHA2025! GPM Symposium Model Systems: Preclinical to Phase I Bridge Nov 7 12:30-5:15 Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

Amid the hype of using polygenic scores for embryo selection, some thoughts on their implementation potential in real-world settings (and problems) 👇

Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365) 👉29,139 locus-trait pairs 👉2,624 non-overlapping loci across the genome 👉associated with 6 traits each (median) 👉colocalization across traits for 72% of loci [1/3]

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

ft. Cardone, Zhang, Noah, @sabramowitz.bsky.social, Sharma, DePaolo, Conery, Hoffman-Andrews, Judy, @noshreza.bsky.social, @5inghalp.bsky.social, Arany, Cappola, Day, Owens, @danrader.bsky.social @marylynritchie.bsky.social @bvoight28.bsky.social, Levin & Damrauer www.nature.com/articles/s41...

Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!

105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience

Angiographic Burden of Coronary Atherosclerosis Contributes To Adverse ASCVD Outcomes Independent Of Traditional Risk Factors https://www.medrxiv.org/content/10.1101/2025.04.06.25325252v1

Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtv

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events www.ahajournals.org/doi/10.1161/...

CXCL12 drives natural variation in coronary artery anatomy across diverse populations @cellcellpress.bsky.social @tassimes.bsky.social www.cell.com/cell/fulltex...

Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29 Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social www.sciencedirect.com/science/arti...

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. https://ja.ma/3W8RykL

🚀 Here are key takeaways from today's JAMA and JAMA Cardiology presentations at #AHA24: Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ➡️ ja.ma/4#AHA24KewpK

🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star #SarnoffCardio fellow Sarah Abramowitz!

Excited for these trainee presentations from the lab at @ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!