GWAS finds millions of variants — but what are the Predicted Effector Genes (PEGs)? Our Nature Genetics Perspective rdcu.be/eoqVk showed big inconsistencies. At ASHG 2025, we’ll introduce a new standard to make PEG data FAIR. 🗓️ Ancillary Session: Oct 17 | 11:45 | Room 259A 📌Poster: Oct 16 | 2:30

🌏 Shaping Together 🌏 Last year, we hosted a workshop on Predicted Effector Gene (PEG) lists - key data linking GWAS signals to biology 👉 kp4cd.org/2024_PEG_wor... This #ASHG25, we share a proposed PEG standard 🗓️ Ancillary Session: Oct 17 | 11.45AM | Room 259A 📌Poster: Oct 16 | 2:30PM | Poster Hall

🚩1 MILLION curated associations!!! 🚩 Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years! See some data insights tinyurl.com/mw53njbb #OpenAccess

🚨NEWS!! OUR REST API V2 IS OUT!!! 🚨 ✅Find more data available thanks to new endpoints ✅New search and filtering functionalities ✅Integration with resources like Ensembl REST API v1 available until May ’26 More details tinyurl.com/bdzdbyuu

🚨 Join us at #ASHG25!🚨 We’re unveiling a new standard for Predicted Effector Gene (PEG) data - designed to make gene prioritisation more transparent, reusable, and #FAIR. #HumanGenetics #GeneticsDiscoveries #EffectorGene #GWAS #FunctionalGenomics #PEGstandard👇

We don't know the answer to this one....anyone else?

🧬 New @emblebi.bsky.social service beta launched: Perturbation Catalogue 🔎 Browse genetic perturbation datasets 🧠 Train models 🧬 Interpret variant function 🧭 Explore gene dependencies Search, test APIs, suggest datasets, send feedback! 🔗 www.ebi.ac.uk/perturbation... Funded by @opentargets.org

🚨 IMPORTANT UPDATE 🚨 👩🏻‍💻👨🏻‍💻Work on #gwas? 📊Did you submit your #SumStats (bit.ly/38rNSjx) or are you planning to do so? Now you can ALSO submit the top associations to be included in the GWAS Catalog! Just follow the link in your submission confirmation email for more details!👇👇

🚀 The Summer ☀️ @opentargets.org Platform release is here! If you thought the last update was big… just wait till you see what’s inside. A quick thread on the highlights 👇

If EMBL-EBI managed data resources have ever saved you time & effort, this is your chance to give back! Fill in a 15-minute survey to help us: 🌍Demonstrate the real-world impact of our resources 🤓Understand your needs 🌟Secure continued funding Closes 16 July www.surveymonkey.com/r/QGFMBH8?ch...

❓Has anyone looked at the overlap between MVP and All of Us? Big enough to worry about when training/testing PGS? cc @sritchie73.bsky.social @iamslambert.bsky.social

🚨Interested in which genes are the true effectors behind the scenes of the #gwas results? 🚨 This new publication in Nature Genetics, a collaboration between @broadinstitute.org @ebi.embl.org @opentargets.org focuses on approaches to predicted effector gene reporting tinyurl.com/98yxy4hf (1/3) 👇

Polygenic scores (PGS) offer insights into a person’s inherited risk of disease. GeneticScores.org is a new platform that enables secure, cloud-based calculation of polygenic scores to make genomic risk prediction more accessible. www.ebi.ac.uk/about/news/u... 🖥️🧬

We’re getting excited for #ESHG2025! Check out poster EP18.012 to be first to find out about the GWAS Catalog REST API v2.0!! Supporting programmatic access to our data, the REST API has been completely redesigned according YOUR feedback. Try it out and let us know what you think!

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

Ensembl release 114 is now out! We have now updated human data to MANE v1.4, new and exciting rodents, livestock, plants and insect genome 🐀 🐈‍⬛ 🪲, lots of species with variation data (@evarchive) and much more! More details on our blog (tinyurl.com/3v7cz2sm)%22 #Genomes #bioinformatics

MAINTENANCE ALERT! GWAS Catalog trait pages are currently failing to load. Our infrastructure team are working to fix it 🤞

Dig further into GWAS data on the NEW Open Targets platform! Congrats to the @opentargets.org team on the new release!

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

Are you interested in GxE interaction #gwas? Now, you can identify and filter them on our website! Check the great review made by @genandgenes.bsky.social et al. at @johnshopkinssph.bsky.social They also analysed the data we hosted and showed a lack of #SumStats available. tinyurl.com/bdfmsmtd

Did you know? We are a Global Core Biodata Resource! Read Global BioData's white paper regarding working collaboratively for funding and sustainability: tinyurl.com/bdhxtnkr Blog about it: bit.ly/3EoWUTj #openaccess #biodata

It is #WorldCancerDay and you can access ~ 2500 #gwas linked to cancer, with close to 1,100 of them with #SumStats. THANKS for helping us to increase the data available following #FAIRprinciples. Share your data bit.ly/38rNSjx #OpenAccess

At #fog2025 @markeffingham @ukbiobank.bsky.social is giving updates about #UKBiobank Did you know we are hosting more than 38K #gwas from UK Biobank lot of them with #SumStats? Access them through website and API, submit your data bit.ly/38rNSjx #openaccess

Did you know? We are a @ELIXIREurope core data resource! Now, Tim Hubbard, Elixir’s Director speaks about @emblebi and multiple projects like @gdi building infrastructure for Europe, #federatedata @EGAarchive @BYCOVID_eu #OpenAccess #datasharing @FoGenomics #FOG2025

Now @adamrutherford.bsky.social speaking about scientific racism. Mentioning the golden ages for #gwas but also that public comms in #genetics and education need changes to decrease eugenics and racism #FOG2025

We are at #festivalofgenomics listening to #timspector speaking about “Genetics, microbes and future of personalised nutrition” mentioning value #gwas had in the field. Also importance of #nutrition, #gutmicrobiome, healthy habits., for that education is key

Thanks to everybody who joined us on this platform as an alternative to connect again! Please share the account with your colleagues and let's work together as #gwas community! #openaccess #FAIRprinciples

Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess

Bridging The Diversity Gap - an important end of year read! Missingness of global ancestries in GWAS impacts the development of diagnostic tools and targeted therapies. www.sciencedirect.com/science/arti...

Today, our colleague @mariacerezo.bsky.social delivered the latest training of the year at the School of Clinical Medicine, @cambridgeuni.bsky.social. Would you like to know more about how to access or submit data? Contact us and/or check ebi.ac.uk/gwas/docs/re... #OpenAccess

NEWS! We are happy to announce our latest resource update paper has been published in Nucleic Acid Research! 🎉 tinyurl.com/4s9bvv2f You can find a summary in our blog tinyurl.com/527tu5s5 or check this 🧵👇

NEWS! Check our wrap-up about #ashg24 shorturl.at/WcTiz Something is missing? Let us know! 🙌 Thanks, ASHG, for giving us the floor to share updates with #genetics community, delivered by our colleague @mariacerezo.bsky.social #OpenAccess #gwas #gwasdatahero Stronger together @ebi.embl.org @NIH

HELP! Our survey is still open! Which information would you like to see in @GWASCatalog regarding #populationdescriptors? 📝 Fill out the survey (less than 1 min!) shorturl.at/kkCEZ 🗣️ Share with #gwas colleagues #OpenAccess #Diversity #FAIRprinciples

HELP! Which information would you like to see in @GWASCatalog regarding #ancestry? 📝 Fill out the survey (less than 1 min!) shorturl.at/kkCEZ 🗣️ Share with #gwas colleagues #OpenAccess #Diversity #FAIRprinciples

Interested in 🌈#Diversity? 📊Check our updated analysis on the distribution of #ancestry labels at shorturl.at/gv6Gx 👥Join us at #ASHG24 @GeneticsSociety "Diversity in the NHGRI-EBI @GWAS Catalog: addressing disparities while promoting accessibility and data sharing"

🛫 Going to the #ASHG 2024? 🗓 Building your schedule after checking the program? 🤓 Interested in #gwas #diversity? 🤝 If so, let's meet!! 6th Nov at 9:00 AM Diversity in the NHGRI-EBI @GWAS Catalog: addressing disparities while promoting accessibility and data sharing #openaccess #genomics

HELP! 💻 Are you accessing programmatically to GWAS Catalogue data? (1) via the #GWAS Catalog #REST_API (2)via #gwasrapidd (R) (3)via #pandasgwas (🐍) (4) Other? Fill out the survey and help us to improve! forms.gle/u4p4asLvGDAL... ⏰ Less than a minute! #openaccess #FAIRdata

#gwaxplanation #traitpage How do you find studies associated with a trait? Search for the trait of interest -> select trait page -> untick ‘Include child trait data’ (child traits are the descendants of a trait)->click on the ‘Studies’ tab ->export the result (1/2)👇👇

Are you going to #eshg? Join our workshop TODAY shorturl.at/zYurA and learn how to: 📚Prepare your data for submission to the @gwasCatalog and @PGSCatalog ✅Access harmonised #gwas #SumStats and scores 🧮Calculate scores from existing PGS in new samples using PGSC_calc?

HELP! Do you use @GWASCatalog data and/or any other data managed by @emblebi? ✔️ Fill out the survey shorturl.at/wOCO3 🕰️ Less than 10 min 🗓️ Before 7th June #openaccess

To celebrate #DNADay and our #anniversary we created some short #tweetorials called #gwasplanation for our variant pages🧵👇

NEWS!! #DNADay24 and our #anniversary!! Here you can see the increase in our dissemination through the website and API #openaccess #FAIRdata

NEWS!! #DNADay24 and our #anniversary!! Our latest data release is out! Now access to ~607,000 assoc published in 6,827 publications from 100,240 #gwas and 79,604 #SumStats datasets! Share your data bit.ly/38rNSjx #OpenAccess

SURVEY ALERT!! Are you generating lists of effector/causal genes based on GWAS? Interested in using other’s lists? Hampered by lack of standards & infrastructure? Together with @KPortalNetwork we want your input to a new standard: docs.google.com/forms/d/e/1F... #gwas #genomics #FAIRdata

Are you going to #FOG2024? Interested in health inequities in #genomics? What about our latest updates? Meet us there for the roundtable, check our poster and obtain a #gwas data hero pin!