At #EASD and interested in learning about how polygenic risk scores can be use to improve prediction and prevention of type 2 diabetes? Come see my talk at 17:25 today in the Milan Hall as part of the EASD-ADA Joint Symposium. I'll also be around until Friday afternoon if anyone wants to chat.

⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI! ⏳ Closing September 16th. ✏️ Apply here: tinyurl.com/2ukkp8yx Or learn more about what we do at www.lannelongue-group.org Initial examples of research projects below 👇

Super excited to see beginning integration of PredictDB into OmicsPred! We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org More on its way... a wonderful collab with @hakyim.bsky.social & co!

Has Antony Green called the Eurovision winner yet? #eurovision #auspol #stillwaitingfortheprepolls

Estonia hands down

Feeling mildly emotional that this is Green’s last election coverage. He’s covered every Aus election I’ve ever seen, it won’t be the same without him #auspol

Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org ! www.embopress.org/doi/full/10.... A short thread on our key findings 🧵👇

📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41... Check out the INTERVAL RNAseq portal www.intervalrna.org.uk Led by @alextokolyi.bsky.social & Elodie Persyn!

Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41... Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!

New pre-print led by @hwang_seongwon: "Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes": www.medrxiv.org/content/10.1.... Brief thread follows:

Our latest Study just went online: Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)

Out today in Nature Cardiovascular Research, Rasooly and colleagues utilise multiple sources of multi-omic evidence to identify new drug targets for heart failure with reduced and preserved ejection fraction: www.nature.com/articles/s44...

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease academic.oup.com/eurheartj/ad... A clinical consensus statement of the ESC Council on Cardiovascular Genomics, ESC Cardiovascular Risk Collaboration and European Association of Preventive Cardiology

A platform for the biomedical application of large language models https://www.nature.com/articles/s41587-024-02534-3 (read free: https://rdcu.be/d68Ih) MIT licensed https://github.com/biocypher/biochatter 🧬🖥️🧪

Excited to be tutoring at the Leena Peltonen School of Human Genetics on July 27-31, alongside a stellar crew. If you’re a late-stage or recently graduated PhD student this is an awesome opportunity to get 1:1 time with faculty at the cutting edge of genomics. Apply by March 7th at lpshg.com

⏳ Just one more week to apply! 5 roles open in my group working on the Green Algorithms project: 3 research, a Software Engineer Lead and a Community manager/project coordinator 🌱 More details and links to all adverts there: www.green-algorithms.org/join-us/ Closing 25/11 #AcademicSky #SciSky

check out our new preprint led by Charles Zhou and supervised by Mengjie Chen and me doi.org/10.1101/2024... where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework

Announcing version 3.2.0 of the ukbnmr R package now available on CRAN: cran.r-project.org/web/packages... This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025

For my debut to bluesky, I am pleased to announce a new preprint: medrxiv.org/content/10.1... Here, we show that NMR biomarker scores combined with PRSs and SCORE2 may have moderate population health benefits for 10-year CVD risk prediction prevention Thread 1/3: