New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)! We're looking for someone keen on bioinformatics and microbiome evolution. Important info below on eligibility & URSA competition funding👇 www.findaphd.com/phds/project...

If I’m understanding this correctly, X is owned by a white nationalist who pays poor people of color in developing countries to pretend to be working class white Americans to scare other white Americans into being afraid poor people of color from developing countries are going to ruin America?

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

Emperor Palpatine xkcd.com/3157/

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI! ⏳ Closing September 16th. ✏️ Apply here: tinyurl.com/2ukkp8yx Or learn more about what we do at www.lannelongue-group.org Initial examples of research projects below 👇

KASIE HUNT: Over the summer you said, “There’s no vaccine that’s safe and effective”. Do you still believe that? RFK JR: “I never said that.” KASIE HUNT: “Play the clip.” RFK JR (clip): “There’s no vaccine that is safe and effective.” (March 2024) ht: @cwebbonline.com

Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... ) 1/2

An abbreviation (ABB) in a journal article (JA) or Grant Application (GA) is rarely worth the words it saves. Every ABB requires cognitive resources (CR) and at my age by the time I'm halfway through a JA or GA I no longer have the CR to remember what your ABB stood for.

Double the discovery, double the momentum 🚀 Europe doubles down on research competitiveness with a major boost to #HorizonEurope: €95.5 billion foreseen for 2021-2027 💰💰💰💰💰💰💰💰💰 €175 billion proposed for 2028-2034 💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰

The Guardian's take on the new interim NASA administrator: "Duffy has no scientific background, but does have experience with transportation, as a former contestant on the MTV reality TV game show Road Rules, a Winnnebago driving contest." the USA is soooooo fucked...

Summary of the significant evidence that the B-2s currently airborne are a strike package heading directly for Iran: 1. Immediate refuelling after departing from Whiteman Air Force Base indicates that the aircraft are carry close to their maximum payload.

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org More info www.omicspred.org/publication/...

Super excited to see beginning integration of PredictDB into OmicsPred! We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org More on its way... a wonderful collab with @hakyim.bsky.social & co!

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

ICYMI: Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities www.nature.com/articles/s41... Collaboration with @astra-zeneca.bsky.social throwing up very interesting targets including FAM3D (T2D), ITIH4 & EFEMP1 (CVD in those with T2D)

We are now on Bluesky! Follow us to keep up to date with our research and find out what goes on at the Cardiovascular Epidemiology Unit in the @dphpc.bsky.social #cardiovasculardisease #prevention #healthcare #bigdata #globalhealth #publichealth #riskfactors

Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this

📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱 🚨Closing June 5th www.jobs.cam.ac.uk/job/51255/ Topics below 👇 #AcademicSky #GreenSky

📣📣 Thrilled to see this cool work finally out in the wild! "Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology & prediction" www.nature.com/articles/s41... Loads of cool findings including MR for alcohol usage -> increased variance in BC traits

Our new work testing nicotine, alcohol, and caffeine exposure across many cell types at once, including their modulation of eQTLs. Take a look!

Absolutely brilliant news. It was so important that the govt organised British re-entry to Horizon: UK wins £500m in science grants from EU Horizon scheme after Brexit lockout www.theguardian.com/science/2025...

Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a... Cohort description: www.ctsu.ox.ac.uk/research/pro...

Cuts to #NIH funding don't just hurt scientists, but everyone who depends on new treatments, cures, & medical breakthroughs. Research can't thrive without strong, sustained support. Read more in this @60minutes.bsky.social segment featuring former NIH director Francis Collins: buff.ly/REjVWPc

A reminder for people looking for postdocs, our lab has an opening! www.jobs.cam.ac.uk/job/50966/ 👇 bsky.app/profile/mike...

On the super cool aetiology side: Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease www.embopress.org/doi/full/10....

📣 Thrilled to share this paper. We leveraged transcriptomic data from one of the largest existing aortic valve collection. We identified genes/pathways involved in disease progression/severity, with distinct transcriptomic signatures in TAV vs BAV. Perspectives for potential therapeutics? See more👇🏽

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

Tariffs xkcd.com/3073

A major paper @nature.com this week found a significant decline in dementia after an outdated Shingles vaccine. I've reviewed the study and many other relevant ones here erictopol.substack.com/p/the-shingl...

Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org ! www.embopress.org/doi/full/10.... A short thread on our key findings 🧵👇

It’s completely bonkers. The U.S. tariff calculation method, explained by @financialtimes.com’s Alexandra Scagg: www.ft.com/content/e025... (free to read)

📣📣 Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease 👉 www.embopress.org/doi/full/10.... Very excited to see this highly innovative study led by @cfoguet.bsky.social finally out in MSB!

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41... Check out the INTERVAL RNAseq portal www.intervalrna.org.uk Led by @alextokolyi.bsky.social & Elodie Persyn!

ProPublica looked into science grants that Ted Cruz's team flagged as "radical" and "neo-Marxist" and, uh. This would be good comedy if it didn't matter so much www.propublica.org/article/ted-...

Wonderful to see our collaboration @astrazeneca.bsky.social @dphpc.bsky.social out! Identification of plasma proteomic markers underlying polygenic risk of T2D and related comorbidities @naturecomms.bsky.social www.nature.com/articles/s41... Well done Doug Loesch, Dirk Paul, Abhishek Nag and co!

Thank you London Metabolomics Network organisers for inviting me and for putting together this fantastic meeting. Great talks, and most importantly, great discussions! Also very pleased to be reunited with Marta Cascante’s alumni Carles Foguet and Cristina Balcells!

A huge welcome to bluesky for the Polygenic Score Catalog @pgscatalog.bsky.social 🎉🎉🎉🎉🎉 Check out the latest at www.pgscatalog.org

Announcing version 3.2.0 of the ukbnmr R package now available on CRAN: cran.r-project.org/web/packages... This is a major update that makes the package compatible with the UK Biobank Research Analysis Platform and shows removal of technical variation on the full NMR data release coming Jan 2025

Hello world!