Looking forward to a week long visit to @bakerresearchau.bsky.social in Melbourne next week! Part of a long standing partnership with Cambridge and with plans to (hopefully) grow in exciting new research directions! baker.edu.au/who-we-are/o...

Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

🧬 PRSs in practice (5/5): Are healthcare professionals ready? A concern about PRSs is that clinicians lack genomics knowledge or risk-communication skills. The solution is not to avoid PRSs, but to invest in training & support. Read my paper with @mikeinouye.bsky.social 👉 rdcu.be/eNeKN #Genomics

✨ It was a real pleasure to host @mikeinouye.bsky.social today! A fantastic seminar connecting polygenic scores with multi-omic profiles — showing how integration can power next-generation disease prediction. #systemgenomics

🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public? A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky. But is that really true? 🧵

🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress? Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited. 👉 rdcu.be/eNeKN #Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety

Gave a talk at the Cambridge Alumni Festival on the genetics of common diseases. It's high level but came off well I think. www.youtube.com/watch?v=xF_p...

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood

PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score... Our results were surprising... 👉 www.medrxiv.org/content/10.1...

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1... Very cool results: Accumulating E with age reduces heritability & PGS effects Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social

Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-... There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!

New episode of the Health Data Science Insights podcast has dropped! This one with Prof Tim Chico on his beginnings in research and now on using smartphone and wearable data to improve cardiovascular care. open.spotify.com/episode/045Y...

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791... You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

Published last month @nathumbehav.nature.com from Saskia Sanderson and me: "Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice" www.nature.com/articles/s41...

Wrote a short blog on personalised health for the Public Health Genomics Foundation. Believe it or not I actually wrote it before the NHS 10 Year Plan came out... www.phgfoundation.org/blog/making-...

The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...

Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .

Super excited to see beginning integration of PredictDB into OmicsPred! We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org More on its way... a wonderful collab with @hakyim.bsky.social & co!

Can deep-learning be used for polygenic risk scores? New paper out in @natcomms.nature.com! To find out more read here: www.nature.com/articles/s41... @mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social

📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co! Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1... The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!

Another great article from @mikeinouye.bsky.social and his team 📖Read more here www.nature.com/articles/s41...

Polygenic scores (PGS) offer insights into a person’s inherited risk of disease. GeneticScores.org is a new platform that enables secure, cloud-based calculation of polygenic scores to make genomic risk prediction more accessible. www.ebi.ac.uk/about/news/u... 🖥️🧬

PGS Catalog Calculator link: pgsc-calc.readthedocs.io/en/latest/ Recent paper here 👉 www.nature.com/articles/s41...

We havent plumbed the tails specifically... I wouldnt be surprised if there was something (an enrichment of GxG) there. I've definitely still got the GxG antennae up (eg www.embopress.org/doi/full/10....) but am on the skeptical side of it improving PGS. I need to hear more about your Medaka work!

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

Its been an absolute pleasure to have @gmeric.bsky.social in the lab for the last 7 years (omg has it been that long) Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!

NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources. If anyone has a spare £1m plz DM

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

ICYMI: Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities www.nature.com/articles/s41... Collaboration with @astra-zeneca.bsky.social throwing up very interesting targets including FAM3D (T2D), ITIH4 & EFEMP1 (CVD in those with T2D)

Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl

We are now on Bluesky! Follow us to keep up to date with our research and find out what goes on at the Cardiovascular Epidemiology Unit in the @dphpc.bsky.social #cardiovasculardisease #prevention #healthcare #bigdata #globalhealth #publichealth #riskfactors

New research reveals that metabolic reactions can amplify or buffer the impact of coronary artery disease risk alleles on susceptibility ➡️ www.embopress.org/doi/full/10....

The application of polygenic risk scores (PRS) in clinical practice has advanced but also received criticism. In this Perspective by Saskia Sanderson & @mikeinouye.bsky.social, major psychological and behavioural arguments against PRS applications have been assessed. www.nature.com/articles/s41...

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this

📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱 🚨Closing June 5th www.jobs.cam.ac.uk/job/51255/ Topics below 👇 #AcademicSky #GreenSky

Excited to share that I presented a poster on two risk communication projects I’ve led during my PhD — and was honoured to win a poster prize yesterday at the BHF CRE / Cambridge Cardiovascular annual symposium! @cambridgecardio.bsky.social @vpd-hlri.bsky.social @cambridgebaker.bsky.social

📣📣 Thrilled to see this cool work finally out in the wild! "Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology & prediction" www.nature.com/articles/s41... Loads of cool findings including MR for alcohol usage -> increased variance in BC traits

Can testify to this -> awesome research environment, with access to great ressources, sharing space and time with incredible colleagues and renowned experts...

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

Finally, I want to thank all the people and organizations that made this work possible including: @mikeinouye.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @cambridgebaker.bsky.social @cambridgecardio.bsky.social @dphpc.bsky.social @thebhf.bsky.social @wellcometrust.bsky.social

If you want to know more about genetically predicted fluxes and how they are computed, I recommend reading our previous work: www.nature.com/articles/s41...

In this work, we use genetically predicted reaction fluxes to perform a systematic search for metabolic fluxes acting as buffers (negative interaction effect) or amplifiers (positive interaction effect) of coronary artery disease (CAD) risk alleles in UK Biobank.

Our work on metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease is finally out in @molsystbiol.org ! www.embopress.org/doi/full/10.... A short thread on our key findings 🧵👇