thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE

Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...

Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...

Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z

New position in Geneva jobs.unige.ch/www/wd_porta...

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale. 🔗 www.nature.com/articles/s41...

Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne

well done part I @erinltempleman.bsky.social

Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...

Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...

BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...

Wow. Amazing investigative journalism: observer.co.uk/news/nationa...

Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.

interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...

Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch) 🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!) 🎤 Oral presentation notifications: 7 July ✅ Early Bird registration deadline: 11 July 💰 Registration fee for non-PI: 150 CHF

Danny Boyle «  The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...

I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.

Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .

there's that big gap between MAF 0.01 and 0.001 again...

In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war. www.wsj.com/tech/biotech...

Sad news. This song blew Paul McCartney away at the time apparently. I guess we're going to have to get used to this as the heroes of 1960s pop travel through their 80s (if they made it past 27) www.youtube.com/watch?v=lpd4...

One of the things that is getting better.....

To add to your weekend reading, check out this nice report on the Genes & Health cohort from Hye In Kim, David van Heel and many many more: www.medrxiv.org/content/10.1...

A big day for sport, after Coco Gauff yesterday. Maybe the first big insight into whether or not these two guys can replace the entertainment and drama provided by the big 3. www.bbc.com/sport/tennis...

Congratulations to Lauric Ferrat for this funding from the local Diabetes Suisse Romande foundation, for work he is leading in Type 1 diabetes. fondation-diabete.ch/res/Newslett...

Good to see we can keep PRS simple.

Well this couldn’t have come at a better time www.bbc.com/news/article...

Essential weekend read www.theguardian.com/world/ng-int...

lovely stuff from @genesandhealth.bsky.social team (i missed the name of the v talented presenter). Human knockouts as preclinical drug safety "models" #ESHG2025

Gareth pointing out issues of low coverage of coding genes and long range haplotype effects (D' values medium range despite r2 very low) that can confound rare variant signals. #ESHG2025

Already-risen Exeter star Gareth Hawkes @drghawkes.bsky.social following up with the latest master class in how to use WGS data, >1 billion variant based GWAS. They bypassed the WES era as didn't want to leave out 99% of the genome :-) #ESHG2025

Harry is also pointing out very nicely how apparent excess heritability in very rare variant freq. bins does not coincide with common variants, unlike (less) rare variants, suggesting artefacts in the very rare bins #ESHG2025

Current speaker Harry Wright in plenary session has been working in human genetics for 14 months. Another star in the making from the Exeter team #ESHG2025. Pointing out non coding aggregate signal in FGF18 for height, the gene has no coding signal (very constrained gene).

OK, I'm starting to get #ESHG25 FOMO now! Those of you who are there should check out a poster from our group @hls.exeter.ac.uk investigating penetrance of variants in TSC1 & TSC2, with implications for newborn genome screening.(P15.033.D - pop by for a chat Monday 4-5pm)

3 euros 60. The change from a 5 euro note after purchasing an excellent coffee americano in Milan.

#ESHG2025 Don't miss the posters from our new Geneva Common Disease Genomics team using WGS data in common phenotypes. from Aurelie: P18.045.D Whole-genome sequence analysis of 450'000 individuals across diverse populations identifies new rare and low-frequency colorectal cancer risk variants

#ESHG2025 Don't miss the posters from our new Geneva Common Disease Genomics team using WGS data in common phenotypes. from Liza P18.055.B Novel rare variants underlying adiposity-related traits: A whole-genome sequence analysis of 745,000 individuals across diverse populations

#ESHG2025 Don't miss the posters from our new Geneva Common Disease Genomics team using WGS data in common phenotypes. From Lauric: P18.074.A Whole-Genome sequence analysis of 600,000 individuals across diverse populations identifies rare alleles with large effects on type 2 diabetes

#ESHG2025 hearing from the All of Us study leaders, starting with CSO Geoff Ginsburg (remotely). Emphasizing the inclusion of "people who have not had the opportunity to be part of research before".

The Neanderthal skull has amazing teeth. I guess they did not eat much sugar, but even so ? #ESHG2025

Steve McCarroll plenary. Amazing to go back to Huntington's disease, and learn there is nothing toxic about inherited CAG expansion, its their random somatic expansion over a relatively short period of time. Explains a lot about later onset of condition. #ESHG2025

yes this neat technique was used by @explodecomputer.bsky.social a while back to quantify the heritability of body mass index.

Overview of our genetics of multimorbidity (GEMINI) project by @timfrayling.bsky.social at the MLTC symposium We are studying 72 common long-term chronic conditions with a heritable (genetic) component. Our seminal paper is now published (doi.org/10.1016/j.eb...) and our public resources are below:

thanks @genesandhealth.bsky.social amazing contribution

To underpin GEMINI #multimorbidty #MLTC research the team defined 84 common chronic conditions with curated code lists all available on our GitHub site github.com/GEMINI-multi...

GEMINI « atlas » of #Multimorbidity #MLTC paper here www.thelancet.com/journals/ebi...

The main output from GEMINI : an atlas of 2546 pairs of common chronic conditions in primary care and genetic data . Browse the data including underlying datasets in meta-analyses: #MLTC gemini-multimorbidity.shinyapps.io/atlas/

The GEMINI team: a fantastic group of researchers using multiple multi-modal primary care and genetic datasets to help understand 2546 pairs of long term common conditions. #MLTC

Scored again last night in front of 92,000 people at the Nou Camp. Wonderful story of an immigrant kid (still literally, he will be 18 in July) www.theguardian.com/football/202...

ICYMI. from two superstars of this topic, an important addition to the portfolio of studies showing how human genetics informs all aspects of drug development journals.plos.org/plosgenetics...