Update from Claude

Catch up on Switzerland's mature Trusted Research Environment for working with sensitive data , including from multiple hospitals across the country. thanks to the hard work of Owen Appleton Sabine Österle , Shubham Kapoor & many others. www.youtube.com/watch?v=XsnE...

Learn about working securely with data from 10% of the Swiss population : 📚 The SPHN Federated Clinical Routine Dataset: 🗣 Referenten: Dr. Sabine Österle 📅 Wann: Dienstag, 10. März 2026, um 16:45 Uhr 📍 Wo: Online via Zoom: bit.ly/4e9p3Ka #SPHN

Fantastic opportunity en Suisse: www.linkedin.com/posts/swiss-...

Amazing. UK leading the way . Finland in silver medal position ? and I predict Switzerland could join them on the podium at some point over the next year or two

yep. seems like we need to try, but also that most components of disease are on a continuous scale. Put people into groups based on those scales and they will look different, but are the separations real ? doesn't rule out the importance of stratification to get more bang for intervention buck

Congratulations @laferrat.bsky.social & team.

slightly random reminder of this paper from 2019 from Exeter colleagues that shows how heterogeneity of disease, in this case diabetes, is best dealt with by using continuous clinical variables not cluster assignment: www.sciencedirect.com/science/arti...

excellent opportunity with SPHN , making health data from > 10% of the Swiss population safely reusable for research apply.refline.ch/499599/0353/...

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

Using genetics to understand multi morbidity, including neat R package to "subtract" effects of critical risk factors such as obesity : www.nature.com/articles/s43...

great work & just as interesting is use of this approach to estimate the shared genetics between pairs of conditions whilst "subtracting" the effects of obesity. Interesting that T2D-Osteoarthritis genetic link estimated as 100% about obesity, other pairs clearly have strong non obesity components

The Exeter team seem to be the Alex Honnold of human genetics. Most sane people on seeing the challenge of meta analysing >1billion variants & 10,000s aggregates across ~100% of the genome would opt for the safety rope of the exome. Not these guys.

ten percent of the Swiss population: Medical meta data update: www.linkedin.com/posts/swiss-...

Learning more about the brilliance of the medical record data at the University Hospital Geneva. This plot, from pubmed.ncbi.nlm.nih.gov/34643542/ shows how medical informatics researchers have introduced , & clinicians passively adopted, a set list of phrases, reducing new free text.

Interesting development in ”non-personalised Medicine” from UK: the government will reduce the current lower threshold at which Soft drink industry levy applies from 5g of total sugars per 100ml to 4.5g & will remove the current exemption for milk-based drinks with added sugar

Rarely in the entire history of science, has QC been a topic of such passion, importance and impact. If only the French and Americans had adopted such rigor when they messed up the design of that multi billion $ telescope because one was using the metric system, the other the imperial system.

Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...

Nearly two years in for our new common disease genetics and genomics team at the University of Geneva. Already lots to be proud of. Here is Lauric talking about his award from the local Diabetes charity. fr.linkedin.com/posts/fondat...

I’m learning more and more about the extremely impressive Swiss personalised Health Network and the trusted research environment infrastructure that enables researchers to safely access & Analyse data from multiple hospitals in Switzerland www.sib.swiss/news/sphn-is...

Congratulations to our Liza Darrous for winning the women in data science award last week:  tinyurl.com/lizaprize

thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE

Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...

Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...

Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z

New position in Geneva jobs.unige.ch/www/wd_porta...

Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale. 🔗 www.nature.com/articles/s41...

Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne

well done part I @erinltempleman.bsky.social

Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...

Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...

BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...

Wow. Amazing investigative journalism: observer.co.uk/news/nationa...

Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.

interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...

Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch) 🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!) 🎤 Oral presentation notifications: 7 July ✅ Early Bird registration deadline: 11 July 💰 Registration fee for non-PI: 150 CHF

Danny Boyle «  The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...

I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.

Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .

there's that big gap between MAF 0.01 and 0.001 again...

In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war. www.wsj.com/tech/biotech...

Sad news. This song blew Paul McCartney away at the time apparently. I guess we're going to have to get used to this as the heroes of 1960s pop travel through their 80s (if they made it past 27) www.youtube.com/watch?v=lpd4...

One of the things that is getting better.....

To add to your weekend reading, check out this nice report on the Genes & Health cohort from Hye In Kim, David van Heel and many many more: www.medrxiv.org/content/10.1...

A big day for sport, after Coco Gauff yesterday. Maybe the first big insight into whether or not these two guys can replace the entertainment and drama provided by the big 3. www.bbc.com/sport/tennis...

Congratulations to Lauric Ferrat for this funding from the local Diabetes Suisse Romande foundation, for work he is leading in Type 1 diabetes. fondation-diabete.ch/res/Newslett...

Good to see we can keep PRS simple.

Well this couldn’t have come at a better time www.bbc.com/news/article...

Essential weekend read www.theguardian.com/world/ng-int...

lovely stuff from @genesandhealth.bsky.social team (i missed the name of the v talented presenter). Human knockouts as preclinical drug safety "models" #ESHG2025