Wow! If this holds up, it will be a triumph of science (i.e., of many hundreds of dedicated scientists over decades) over a devastating disease.

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating! Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏

Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.

🚨 News recherche Des caractéristiques telles que la taille, le métabolisme ou encore le risque de développer certaines #maladies peuvent être influencées de manière différente selon que le variant #génétique en cause provient de la mère ou du père. ➡ www.unil.ch/news/1754464...

Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in ‪@nature.com 👍 ‬ www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

Thrilled to see this project come to life — a huge team effort with collaborators in 🇨🇭 🇪🇪 🇳🇴! Huge thanks to all co-authors and funders! @zkutalik.bsky.social @lilimilani.bsky.social @srubinacci.bsky.social @adriaan-vd-graaf.bsky.social @unil.bsky.social @estbiobank.bsky.social and many more !

Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇 www.sib.swiss/news/the-imp...

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

This represents a real tour-de-force by @adriaan-vd-graaf.bsky.social. It has so many strong aspects: (i) establishment of large scale ground truth data for causal inference [metabolomics/transcriptomics]; (ii) sophisticated method and (iii) biological insights through real data application.

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch) 🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!) 🎤 Oral presentation notifications: 7 July ✅ Early Bird registration deadline: 11 July 💰 Registration fee for non-PI: 150 CHF

🔥 18-19/9/25 🔥 Computational Biology Symposium in Lausanne! Meet the speakers: Mo Lotfollahi @sangerinstitute.bsky.social is expert of cutting-edge #AI approaches to study #singlecell biology , #generativeAI, and #spatialbiology lotfollahi.com

You can still apply to this postdoc job opportunity!

Come join 5Prime as we grow our team to use human genetics and other —omics to accelerate drug development. New post for a Software Engineer: 5primesciences.com/careers/

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

Meet another speaker of the Computational Biology Symposium [https://cbiosymposium.unil.ch/]: Blagoje Soskic [https://tinyurl.com/ybs82xuu]! He studies the genetic control of T – B cell interaction and antibody production with innovative combinations of experimental and computational approaches.

Thrilled to receive the Early Career Award for my presentation at #ESHG2025! 🧬 Big thanks to all the amazing collaborators on this project — couldn't have done it without you. Grateful to the organizers and inspired by the science shared this week!

ESHG2025# Early Career awards: For outstanding science presented at the conference - Allison Newman, Exeter, UK - Hristiana Lyubenova, Berlin, Germany - Robin J. Hofmeister, Lausanne, Switzerland - Pau Clavell-Revelles, Barcelona, Spain

Extremely proud of @rjhfmstr.bsky.social for his @eshg.bsky.social Early Career Award received yesterday in Milan. A truly deserved recognition of his outstanding presentation and ingenious research on parent-of-origin effect inference! #ESHG2025

🔥 18-19/9/25 🔥 Computational Biology Symposium in Lausanne! Meet the speakers: Roser Vento-Tormo @sangerinstitute.bsky.social has pioneered computational approaches to study cell-cell interactions with the now legendary CellPhoneDB www.cellphonedb.org #bioinformatics #SingleCell #compbio

🧬 Looking forward to presenting at the #ESHG2025! Our GWAS & EWAS studies of 10,000+ individuals reveal how genetics & epigenetics regulate trace element metabolism. Visit our poster P18.057.D today at 4pm! Huge thanks to @sfb1453.bsky.social, @zkutalik.bsky.social, and all collaborators involved!

🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (@zkutalik.bsky.social) is coming in force!
 Check out our latest work on human genetics! 
📍Come see our talks & posters, or reach out to meet us!

This year's IGES Annual Meeting and Education Workshop will be held Aug. 31 - Sept. 2 in the beautiful city of Cologne, Germany. Join us for an exciting lineup of keynote presentations, platform talks, posters, and hands-on tutorials at #IGES2025! Learn more: www.geneticepi.org/2025-annual-...

Another exciting work by @tabeasch.bsky.social revealing the genetic basis of cognitive and physical decline and it upstream epidemiological drivers.

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

Meet another invited speaker to our Computational Biology Symposium in Lausanne [https://cbiosymposium.unil.ch/]: Andrea Ganna www.atgu.mgh.harvard.edu/people/andre...

Every week, we will post about a different invited speaker of the Computational Biology Symposium in Lausanne [https://cbiosymposium.unil.ch/]. This week's post features Michael Brenner [https://brennergroup.seas.harvard.edu/]!

🔥 Computational Biology is Everywhere! CBIO Symposium in Lausanne cbiosymposium.unil.ch meet our KEYNOTE speaker Michael P. Brenner @harvard.edu brennergroup.seas.harvard.edu Michael's research uses applied mathematics and physics to address problems in life science, engineering, ... and cooking 😎

I'm excited to share our latest work, now out in #PLOSGenetics! If you feel limited by linear models in TWAS or PWAS but don't think you can switch to nonlinear methods due to a lack of individual-level phenotype data, this paper is for you. 🔗 journals.plos.org/plosgenetics... Thread below 👇 (1/6)

Most disease-associated GWAS signals fall in the non-coding genome🧬 Although assumed to influence expression, pinpointing the causal gene isn't easy. Two ways include: 1⃣eQTL mapping in relevant tissues/cells 2⃣in vitro CRISPRi screens This preprint compares the two👇

Very excited to give a virtual talk as part of the @eshg.bsky.social webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...

Come work with us! We're looking of postdoc(s) with experience in bacterial genomics and interest in mathematical modelling to work on bacterial ecology and evolution in the context of public health. tinyurl.com/n34vzszu

We've just posted an updated version of our metabolic trait GWAS preprint. The GWAS summary statistics are still the same as in October, but we've included several new follow-up analyses and completely rewritten the manuscript! See thread below for some highlights. www.medrxiv.org/content/10.1...

Recent study published by the research group of @zkutalik.bsky.social at the DBC @unil.bsky.social, @sib.swiss & Unisanté

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊 Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs. www.nature.com/articles/s41...

Honour to be invited to give a talk by @zkutalik.bsky.social at the University of Lausanne last week 🇨🇭 Thanks for the opportunity to present our work and meet your amazing team 🤩 I presented on genetics and multimorbidity. It was recorded if you would like to watch: rec.unil.ch/videos/dcb-e...

Not a huge surprise, while not the most pressing issue this leaves a lot of science in limbo… www.bbc.com/news/article...

📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬 www.medrxiv.org/content/10.1... 🧵👇 (1/n)

Join us in Lausanne for a newly launched Computational Biology Symposium with a stellar lineup of speakers! Registration and abstract submission open: share your original research work in a friendly atmosphere!

Terrific speaker line-up covering a broad spectrum of biological questions addressed through a common language made of math, statistics and computer science #ai #computerscience #math #physics #complexsystem #evolution #machinelearning #statistics #popgen #genomics #proteomics Please re-post !

After 6 (healthy) months of hiatus from social media, first post with a brand new conference announcement!! 🔥COMPUTATIONAL BIOLOGY IS EVERYWHERE! Join us in Lausanne for the first international Computational Biology Symposium! 18-19 September 2025 Registrations are OPEN! cbiosymposium.unil.ch

Leena created the original Wellcome Trust School for Human Genomics back in 2009. She sent me that year just before completing my PhD and it was amazing, chalk full of world leading scientists mentoring 1:1 with extraordinary PhD students all day long. You won't get this anywhere else 👇👇

Tomorrow is the last day to apply to the Leena Peltonen School of Human Genomics summer program (Wellcome Campus, UK) for scientists nearing the completion of their PhD. 1:1 mentorship from many fantastic tutors! lpshg.com/how-to-apply/

📢 Don't delay! You still have a few hours left to submit your abstract and share your research and expertise at the #bc2basel conference. Choose from 3 presentation formats: 🔹 Oral presentation (15-min incl. Q&A) 🔹 Poster pitch (5-min) 🔹 Poster 👉 Make sure to submit TODAY: bc2.ch/talks-poster...

In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”…. 🧪 #AcademicSky www.nature.com/articles/d41...

Less than 2 weeks left to apply to join the Leena Peltonen School of Human Genetics 27-31 July in Hinxton, UK! If you are a PhD student in your last year or very recently defended your PhD, it's your place to be! lpshg.com