Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

READING RECOMMENDATION 📖 Genes, environment, and aging: What determines cognitive and physical decline? Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.

🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource. Spread the good news! osf.io/preprints/os...

🧠🧬🧑‍🤝‍🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟 A short thread summarising the study👇

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

On June 6th, I'll be giving a keynote talk at the Swiss Federal Office for Public Health! It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉 Join if you can! ☺️

Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n

Very excited to give a virtual talk as part of the @eshg.bsky.social webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...

Come work with us! We're looking of postdoc(s) with experience in bacterial genomics and interest in mathematical modelling to work on bacterial ecology and evolution in the context of public health. tinyurl.com/n34vzszu

The recording of the second episode of our #ESHG Webinar Series is now on YouTube. 🔜 Episode 3 – April 30, 16:00 CEST 📌 "Making sense of genetic associations" 🎙️ Zoltan Kutalik Join for free on Zoom! Register here: buff.ly/l6d0fai

We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊 Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs. www.nature.com/articles/s41...

Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible

Join us in Lausanne for a newly launched Computational Biology Symposium with a stellar lineup of speakers! Registration and abstract submission open: share your original research work in a friendly atmosphere!

🏆 Research integrity consultant and image forensics expert @elisabethbik.bsky.social has uncovered fraudulent data in over 7,600 scientific papers and exposed the practices of ‘paper mills’ that produce counterfeit scientific articles. She is honoured with the €200K Individual Award. Congrats!

The London Genetics Network has arrived on Bluesky! Follow us here if you'd like @ldngenenet.bsky.social

"Selection bias: where are we now?" Incredibly excited to announce the next Causal Inference Interest Group seminar with @haidonglu.bsky.social will take place on 10th March 2025 at 3pm GMT (11am EDT). Don't miss this one! Register at: turing-uk.zoom.us/meeting/regi... #EpiSky #CausalSky #CIIG

New paper by the MoBa PsychGen team on 'direct and indirect genetic effects on early neurodevelopmental traits', led by Laura Hegemann. Now published in JCPP @acamh.bsky.social with @rosacheesman.bsky.social, @ludvigdb.bsky.social, @bstpourcain.bsky.social et al. doi.org/10.1111/jcpp...

🚨 Preprint update! We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals! Discover fresh insights into the genetic architecture of early growth! Updated preprint: www.medrxiv.org/content/10.1...

Last chance to sign up for Dr Kara Kedrick’s talk tomorrow: 👇 𝐂𝐨𝐧𝐜𝐞𝐩𝐭𝐮𝐚𝐥 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐠𝐫𝐨𝐰𝐭𝐡 𝐨𝐟 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐤𝐧𝐨𝐰𝐥𝐞𝐝𝐠𝐞 When: 15. January, 4pm (CET) Sign up here: shorturl.at/X4Ksn @jessiebaldwin.bsky.social @reproducibilitea.org

“Our findings highlight that both self-report accuracy and selective participation are competing biases and sources of poor reproducibility for biobank-scale research” www.nature.com/articles/s41...

Just out in @naturehumbehav.bsky.social ! We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings shorturl.at/N4Qc6

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health. 👉 Read here: www.medrxiv.org/content/10.1... 👇 Highlights below!

PLEASE SHARE: Registration is now open for the next Introduction to Causal Inference Course for Health & Social Scientists (7-11 July 2025, Leeds, UK). See more info & register here: www.causal.training Note, we are not planning any other courses until 2027. #CausalIntroCourse #EpiSky #CausalSky