oh, this is good.

🧠🧬🧑‍🤝‍🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟 A short thread summarising the study👇

This work builds on our previous study, currently under review: www.medrxiv.org/content/10.1... A special thank you to our wonderful co-authors! Engin Keser, @andrealle.bsky.social, @kailirimfeld.bsky.social, Robert Plomin

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible

🧬🌳 New CoDE lab preprint: From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development. www.biorxiv.org/content/10.1... On 🦋: @andrealle.bsky.social @kailirimfeld.bsky.social @laraffington.bsky.social A short thread 👇 (1/9)

🎆It's launch day! Check out our brand new @wellcometrust.bsky.social funded platform to explore over 1,600 datasets from across the world. Find the Atlas of longitudinal datasets here -> atlaslongitudinaldatasets.ac.uk @kingsioppn.bsky.social @mqmentalhealth.bsky.social #AtlasLongitudinalDatasets

Just out in @naturehumbehav.bsky.social ! We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings shorturl.at/N4Qc6

I guess I'm a doctor now?? Huge thanks to the best lab for all the memories over the last 4 years and for the sweetest messages 🥹 @giuliapiazza.bsky.social @emmarubyfrancis.bsky.social @andrealle.bsky.social @josejmorosoli.bsky.social @jessiebaldwin.bsky.social @kxlim.bsky.social

Just posting this to #popgen Here's a link to my notes on population & quantitative genetics: github.com/cooplab/popg... Hoping to extend it more after the winter holidays, as I'm just finishing up teaching the undergrad version of class.

. @jonicoleman.bsky.social & I are looking for a bioinformatics/genetics PhD student in this joint MRC industry PhD scheme "Unveiling Disease-Causing DNA Repeats with Long-Read Sequencing" - a 4 year PhD funded by Oxford Nanopore & The UK MRC. www.findaphd.com/phds/project... #MRCDTP25

Overcomplete models, with more latent than observed variables, model complexity that traditional methods (PCA, SEM & ICA) can't uncover. A tutorial how to fit over-complete models in MCMSEM. MAny potential applications in epi, neuro, genetics & Psych🧠📊 Check it out: rpubs.com/MichelNivard...

I pushed an update for MCMSEM. MCMSEM is an advanced extension of SEM (Developed with Zenab Tamimy and Matthijs van der Zee), which considers not just covariance but also co-skewness and co-kurtosis. It means you can test causal models! github.com/MichelNivard... follow examples in the thread 👇 1/?

How you model phenotypes really matters: "When associations between items and PGSs were not adjusted for all associations between network nodes ... PGSs were associated with a broader set of items than those identified by network analysis." jamanetwork.com/journals/jam...

Here's a pretty good summary of the state of the field for how genetic data can be applied in economics research. On top of tying much of the field together in a consistent framework, there are also a handful of novel theoretical results. Excited to see this out! t.co/d7g1SEEB6C

I have been (foolishly?) searching for peak 2015-2017 twitter "science on socials" magic... In an experiment to recapture that excitement, I talked to @eikofried.bsky.social , in what might veer into podcast territory(?), about a new GWAS of Depression (N > 5 million) www.youtube.com/watch?v=vHvB...

Congratulations to Carl Veller on the publication of his article on confounding in population and family GWAS journals.plos.org/plosbiology/...

I kicked off a series of posts on the "end of GWAS" . It'll be 5 posts, an intro and posts on GWAS of Height, depression, education and schizophrenia, each ample size > 500.000 individuals. I wrote these between jobs to think about whats next for my field & me nivard.substack.com/p/gwas-endga...

Our paper on genetic transmission and genetic nurture effects on conduct problems is now published in Molecular Psychiatry! This version includes new analyses www.nature.com/articles/s41... a 🧵 1/6

We ( @torkildl.bsky.social and @eivindy.bsky.social @tibaier.bsky.social & @kph3k.bsky.social also others not on here) have a paper out studying the origins of widely observed gene-environment correlation for educational outcomes. Paper: rdcu.be/dv1sp let me walk you trough it in a thread 1/?

1/22 Our new paper led by Ashley Watts (w Ashley Greene & @wesbonifay.bsky.social) is now published; I view it as the first critical evaluation of the statistical and theoretical p-factor & resulting literature. Here a brief overview of the core arguments in the paper.

Some useful advice here, but isn't the main reason everyone hates grant writing the very low success rate? A system which requires so much wasted effort just doesn't seem efficient Most scientists don’t enjoy writing grants. Here’s how to change that www.nature.com/articles/d41...

My first post here! advertising our working paper on the 'Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood'  osf.io/preprints/ps... - feedback is welcome!