This… Another thing to “let’s just be cautious” about based on thin evidence base and small effect size (if real!) during pregnancy. The cumulative mental/physical burden of thinly researched potential harms/optimal choices during pregnancy, and during early childhood, is truely staggering….

I still suck at symmetry, it’s really nice to have no pressure to be any good, at all. Pride in doing things without the journal publishing cycle grinding at you is really nice 😅

I still suck at symmetry, it’s really nice to have no pressure to be any good, at all. Pride in doing things without the journal publishing cycle grinding at you is really nice 😅

I also strongly dislike the pushback against this… what’s wrong with an autonomous LLM which you sovereignly (ideally locally) control, it’s a full departure from dependency on the current cloud giants…

people are dunking on the actor who wants an LLM of his own and I absolutely want the same thing. if you can remember everything you read and the origin of all your ideas maybe you should read more just saying

Pages full of bits and pieces, still can’t draw a full face… very liberating and relaxing not to have to be good, ambitious or have goals.

Star Trek, but every time someone in the, clearly near communist Star Trek utopia, isn’t absolutely perfect,m, one of the Bluesky reply people is in the scene. Yelling at Picard: “why havent you condemned capitalism!”…

If I were Starmer/Merz, I’d be on the phone with Silicon Valley all day trying to convince them to move R&D with a global workforce to their country, ideally to areas that need the employment. It be unpopular with the right but both leader got 3/4 years to make it work….

The US as viewed by latenight comedians in Europe (it’s 20 secs of Dutch, the rest is English. We are so worried about you all we’re specifically trying to reach you through our latenight I guess…)

I saw ppl drop everything and race back when the covid flight order came suddenly, that was a solo traveler on a sabbatical, imagine having to drag your fam through airports and spending -15k on “day of” tickets not to loose your life… then your locked in, can’t leave for weddings or funerals…

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries https://www.medrxiv.org/content/10.1101/2025.09.17.25336022v1

Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!

O neat… ( @adamkinzinger.substack.com these jets apparently circled in Estonian airspace for 12 minutes, in your judgement as a former fighter pilot, is there any chance that’s an accident?)

Cool Probability puzzle: I have two children. One is a boy born on a Tuesday. What is the probability I have two boys?

Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!

The US as viewed by latenight comedians in Europe (it’s 20 secs of Dutch, the rest is English. We are so worried about you all we’re specifically trying to reach you through our latenight I guess…)

People’s need for validation, people’s bow to “authority”, and quite frankly the isolation that exists when stretched btwn kids, aging parents, a partnership under pressure, having to support own and partners conflicting needs. It’s the worse situation to add a syncopathic “therapist” into the mix..

Cool work from @ewanbirney.bsky.social Moritz Gerstung, Tom Fitzgerald about modeling health trajectories with generative AI! www.nature.com/articles/s41...

Where would you spend ALL your Hollidays? can only pick one...

The "Snackbar" has gotten some traction in Italy of all places, there are a few news articles a years in Dutch newspapers wondering what the hell is happening.... (I am not kidding.) img.restaurantguru.com/r675-Queens-...

Where would you spend ALL your Hollidays? can only pick one...

Look at the Netherlands and Belgium, clearly its the mayonnaise on the fries that makes em go down so much easier...

New post! A round up of the latest advances in biotech and medicine by @nikomccarty.bsky.social and me. Prime editing, curing whipworm, a new narcolepsy drug, designing protein nanoparticles, the 3D structure of E. coli's genome and more! Read it all here: www.worksinprogress.news/p/whats-new-...

The Manhattanplot of every GWAS is evolving. the top cluster/horizontal band is proteins, the second protein ratio's the third all kinds of microbiome GWAS (which have smaller N and less power, hence the almost empty third horizondal band). I might make this into an interactive shiny website...

The Manhattanplot of every GWAS is evolving. the top cluster/horizontal band is proteins, the second protein ratio's the third all kinds of microbiome GWAS (which have smaller N and less power, hence the almost empty third horizondal band). I might make this into an interactive shiny website...

I now read this (well skimmed, I might be re-reading this again and again) this is really great guidance for people who develop new models, and need to evaluate their identifiability. (I'd have loved some detail on analitical strategies to establish identifiability, but still amazing)

A really neat paper thinking through what "Identifiability" means, how we can determine it, and implications for modeling. Arxiv: arxiv.org/abs/2508.18853 #statssky #mlsky

All results in the entire GWAS catalog, traits color clustered using bert embeddings off their name (very rough...)

All results in the entire GWAS catalog, traits color clustered using bert embeddings off their name (very rough...)

“Michel Nivard was put on injury relief after a 4th quarter irregular tackle by overlooked review commitment (torn multiple ligaments of the soul), he is expected to return for the game against conference rivals University of Bath”

Aw man I wish academics had headlines like this. “Stephen Aguilar (existential dread) is not expected to write today, per @mpolikoff.bsky.social”

I do think very highly of myself, but mostly because I am proud that I am cripplingly aware of the complete incoherence of my own ideas (I swear I try to “cohere” them as hard as I can 😬🤣)

A brilliant 1984 chapter in the "Encyclopaedia of Medical Ignorance" by Richard Peto anticipated much of the advances in understanding of cancer since then, and is now accessible in @SpringerNature European Journal of Epidemiology. A personal on it/ cont link.springer.com/article/10.1...

Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics! academic.oup.com/genetics/adv... We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵

New paper out with @boryslaw.bsky.social 🥳 In which we sketch out how to rethink measurement invariance causally for applied researchers. And provide a causal definition of measurement invariance! www.sciencedirect.com/science/arti...

Settings -> Content and media -> uncheck 'autoplay videos and GIFs'

Slogan ideas… “Smoking hot body or your money back” – crematorium “The first one’s on the house” – chimney installers “We’re not afraid to raise a few eyebrows” – plastic surgeons “We’ll help bring out your inner child” – maternity ward “There’s no turning back now” – neck brace manufacturers

Mansplaining a DAG: casualHIMference…

UC Davis is hiring! A tenure-track assistant professor of psychology, in human cognition or cognitive neuroscience #psychjobs recruit.ucdavis.edu/JPF07300

Slightly diminish a book Guliver’s Jet2Holiday

A phylogenetic protein-coding genome-phenome map of complex traits across 224 primate species. https://www.biorxiv.org/content/10.1101/2025.09.08.674744v1

Animal genetics people! Would it be feasible to do matched artificial selection based on the phenotype vs GWAS + purely additive selection on the genotypes in a model animal and see if you can re-create the same pattern across a pair of plots?

Interesting move, ASML investing into Mistral, which is at the opposite end of the entire tech spectrum, very pleased to see the intra European collaboration! www.reuters.com/world/europe...

Moon 🩸

My kid (8) and her friend are making a game, it’s a dice game of life, the numbered fields correspond to ages, their thinking of rules for the different fields: “25 you are pregnant wait two turns or until you are overtaken” 😬😭

In January semaglutide goes off patentin Canada, India, Brazil, China. With production costs of about ~$6 for a months worth, an avalanche of differences in difference study waiting to happen…. open.substack.com/pub/overmatt...

I highly recommend this!

Go home evolution, you're drunk!

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.