Excited to share our preprint on PGI portability across ancestries—now on bioRxiv. With co-authors @aysuo.bsky.social, @paturley.bsky.social, @alextisyoung.bsky.social, and @Dan_J_Benjamin. Preprint: doi.org/10.1101/2025... Thread below for details.

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

New review on the genetics of schizophrenia, depression, and bipolar disorder. www.nature.com/articles/s41...

UK Genome Science meeting - Newcastle. 9th - 11th July 2025. Great speakers. Great community. Early bird registration-16th May Abstract submission-23rd May Registration close-26th June If you want that sweet sweet early bird deal - get going quick! www.genomescience.org.uk

Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....

Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%! Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1 @eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social

Great work on estimating heritability using sibling relatedness variation (estimated using my software package snipar). Surprisingly low h2 for education and high h2 for IQ (with large SE). Give it a read!

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

A great opportunity to work with @alextisyoung.bsky.social if you're interested in methods development!

🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data. Check it out 👇. It is very cool! geneticscores.org It is linked with the @pgscatalog.bsky.social This was supported by INTERVENE

Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Our UU colleague Wes Sundquist won the 2024 Breakthrough of the year! His long-term research into the structure and function of HIV’s capsid protein has led to the development lenacapavir, a game-changing new treatment that is extremely effective at preventing HIV. www.science.org/content/arti...

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...

Tumour mutational burden: clinical utility, challenges and emerging improvements

Great to see this paper out in Nature today! One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals #icanhazpdf? www.nature.com/articles/s41...

Check out this University of Colorado newsletter that describes work being done by IBG faculty member @dangustavson.bsky.social using the VETSA twin dataset to examine genetic and environmental influences on cognitive decline. www.colorado.edu/asmagazine/2...

I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience. Details here: www.findaphd.com/phds/project...

Review: Inference and applications of ancestral recombination graphs https://www.nature.com/articles/s41576-024-00772-4 (read free: https://rdcu.be/dVyQH) 🧬🖥️

Perhaps this has not been said yet here: Include figures and legends in the manuscript along with the text. Otherwise, I may not read your preprint. If I have to review it without them, I’ll be starting off on the wrong foot. I love science, but don’t make me angry.

🚨IBG is hiring for a Tenure Track Assistant Professor! Candidates should have a background in neurogenetics, high-content genomics, experience with iPSC-derived neurons and glia and neural organoids, and expertise in neurodegeneration. More details here: jobs.colorado.edu/jobs/JobDeta...

The final program for the conference is now up: events.columbia.edu/cal/event/ev...

One more week to apply! We are recruiting a postdoc to work on the evolutionary genetics of admixture in maize and teosinte.

A log Galton board can give an intuition about the drivers of the skewed shape of income distributions. Every success can offer people subsequent opportunities to gain much more while early failures shrink future opportunities Excellent animation by @babeheim.bsky.social

The exome sequencing plus imputation pipeline developed by Regeneron is impressive in its efficiency for discovering genetic associations that are potential drug targets. But having whole genomes for the entire UKB is cool and will prove more useful in the long run www.nature.com/articles/s41...

I made some substantial updates to this blog post with the advice from Isabella Ghement. #rstats #stats

If you like your cheese *very* well-aged: www.cell.com/cell/fulltex... #BronzeAge #aDNA 🧪

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritch...

📣 Attention Stat/Biostat folks on the job market - UBC Statistics is hiring! 📣 www.stat.ubc.ca/assistant-pr...

Overcomplete models, with more latent than observed variables, model complexity that traditional methods (PCA, SEM & ICA) can't uncover. A tutorial how to fit over-complete models in MCMSEM. MAny potential applications in epi, neuro, genetics & Psych🧠📊 Check it out: rpubs.com/MichelNivard...