! Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades www.pnas.org/doi/10.1073/...

After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes. genome.cshlp.org/content/35/8...

Like many others, I'm unable to reach nih.gov on the Web. Moreover, the FTP site for NCBI (ftp.ncbi.nlm.nih.gov) also seems to be unreachable. First time I've seen this in decades.

Finally got this preprinted: "...immunoregulation was observed primarily in mature adult hookworm intestine directly exposed to host blood; it may include hookworm genes activated in response to the host immune system in order to neutralize the host immune system." www.biorxiv.org/content/10.1...

I just realized there was a new canu release, and its the last one: """ Goodbye. Do not expect another release. This is it, folks. The sequencing technology has moved on and Canu is all but obsolete now. Thanks for all the feedback, citations and bug reports. """ 🧬🖥️🦠

"...self-fertility not only required mutations that activated the spermatogenesis program in XX germ lines, but prior to these there must have been mutations that decanalized the sex-determination process, allowing for subsequent changes to germ cell fates." academic.oup.com/genetics/adv...

"...active development of WormBase ParaSite is temporarily on hold, due to a break in funding, and are currently unable to load new datasets." Not good news for anybody analyzing any worm genome, outside of a small set of C. elegans-adjacent nematode species. wbparasite.wordpress.com/2024/12/12/t...

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off. But here's the genome now! www.biorxiv.org/content/10.1...