Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3Ymtiwg

Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? go.nature.com/48AooC4

Want to echo Abdel and encourage reading this excellent commentary he put together!

For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

IBG is saying a fond farewell to former postdoc @isyfoote.bsky.social. Isy was an invaluable asset to the institute in her time here. She is a Wellcome Trust Fellow and new faculty Queen Mary University of London. We can't wait to see what comes next for this exceptionally bright scholar 🧠🧬!

I'm delighted to say that, as of yesterday, Dr. Isy Foote @isyfoote.bsky.social is now my former postdoc as she is staring a faculty position at Queen Mary University of London. Isy is starting the position with a Wellcome Trust Fellowship 🏆. I couldn't be prouder and she will be sorely missed! ❤️

Our new preprint is out: "Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders"! 🧬🦠 www.medrxiv.org/content/10.1...

University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...

University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!! jobs.colorado.edu/jobs/JobDeta... #socialpsychology #cogpsyc #PsychSciSky #PsychJob #psycjobs #psychology 1/n

Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!

Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...

New preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social

Exciting post-doc position available working on my NIH funded project "Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset". Based in the beautiful city of Edinburgh within @edinunilbc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

If you're not following the Behavior Genetics Association account yet (@behaviorgenetic.bsky.social), please do! 🧬🧠🤸🏽 Me and Margot van de Weijer will be running it for the time being, sharing BGA updates and summaries of interesting research from their classic journal 📜 RTs appreciated! 🙏🏽

🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1

New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...

Proud mentor moment! Three preprints recently released from the lab: 1. Postdoc Dr. Isy Foote examined the genetic architecture of frailty. Analyses reveal seven factors of frailty with unique genetic associations, clinical correlates, and biological pathways: www.medrxiv.org/content/10.1...