Keynote speakers: @tuckerdrob.bsky.social @foswald.bsky.social Ellen Hamaker Hands-on workshops by: @tedmond.bsky.social & @ukuvainik.bsky.social (genomic analyses) @dirkwulff.bsky.social (LLMs in personality research) www.ecp22edinburgh.org/programme

A deep and thought-provoking lecture that is definitely worth watching all the way through.

A few related conversations have been converging on the question of when various trends and observations with respect to personality are genuine. This is a complex issue without a simple answer... A key issue is that personality is best measured using self- or informant ratings... 1/

Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social ) “We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.” www.psychiatrymargins.com/p/psychiatri...

Humbled to receive the BGA's early career award ☺️ Thank you to my brilliant team #MPRGBiosocial, the @maxplanck.de for investing in early career researchers, @mpib-berlin.bsky.social for the excellent environment, and my many mentors incl @kph3k.bsky.social @tuckerdrob.bsky.social #ScienceTeamSport

Omg 😂. Well played @michelnivard.bsky.social

O, right I promissed JUICE! Not everyone believes in this work, one of the "haters" was very early... In fact @ent3c.bsky.social practically leant over this papers' crib and said: "well that's not going to be a looker."... Someone just as petty as me, but far more organized, kept the receipts 👇

You will have seen this post by @tedmond.bsky.social‬ on our new GWAS of Personality. He says you should read the paper (you should), I want to write a thread to entice you. Because social media has shredded your attention as it has mine, I promise there is JUICE & BEEF in this thread!

Probably the most important paper in personality psych this decade just dropped. 👀 Interesting genetic correlations between other traits (the #1 reason for GWASs on social traits IMO), and evidence of weak but non-zero assortative mating on personality.

🔥🔥🔥 2 years of our lives right there (extremely proud of everyone, I’ll write a thread later)

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

Super brief video intro-ing the alpha version(!!) of an free studyguide/book in sequence models and deeplearning in/for genomics.

🚨 I just released the alpha-version of my AI in Genomics textbook! It covers (so far!) sequence language models & deep learning for DNA/RNA/proteins. Check it out: biobook.michel.science

Lmao it was all a fucking act. I mean, we all knew it, but it’s funny to see his hypocrisy laid out so beautifully.

We are looking for a scientist passionate about developmental psychology, sociogenomics, and DNA methylation in a cash gift RCT postdocprogram.mpg.de/node/692! 3.5+ yr position in Berlin (until April 30, 2029) integrated into a new Max Planck postdoc program www.mpg.de/en/max-planc... #MPRGBiosocial

We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Whoa, popular online anon obsessed with race-IQ pseudoscience is actually a fringe researcher doing race-IQ pseudoscience who was just hyping up his own work and lashing out at colleagues. Who could have guessed.

I am beyond thrilled that the authors of the MVP GWAS science paper with underflow p values have let me know they are working to address this problem. To those that always say "why do you care about such extreme p-values" here's a graphic depiction.

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

Model traits more precisely across their severity spectrum, elegant combination of psychometrics and statistical genetics by Gareth Ennis and @tuckerdrob.bsky.social

Super interesting

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]

I agree dosage is a big deal here. I encourage anyone with relevant non-experimental data to regress mother and child outcomes on increments of $4,000 annual income. You might be surprised-I was!

Our new review, with Tyler Watts, Emma Hart, and April Yu, summarizing some work in the past few years on "Learning about Development from Interventions" is published open access at Annual Review of Developmental Psychology. Comments, questions, insults welcome. www.annualreviews.org/content/jour...

Barbara Wendelberger, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger Lewis. https://ja.ma/3ZqQV7j

Come for the figure of a hotdog on a skewer, stay for a method that uses genetic data to actually falsify latent variables! Maggie's first first-author pub, btw 😎

@mclapps.bsky.social outlining what I hope will become the fundaments of “molecular genetically informed psychometrics” (I am paraphrasing @tuckerdrob.bsky.social in a convo we had once I think)

🚨 New paper! In this review, we explore factor indeterminacy and outline how we can use genetic data to test the validity of latent factors. tinyurl.com/5n75446y With @tedmond.bsky.social , @tuckerdrob.bsky.social , @kph3k.bsky.social , @andrewgrotzinger.bsky.social , and @michelnivard.bsky.social

We ( @torkildl.bsky.social and @eivindy.bsky.social @tibaier.bsky.social & @kph3k.bsky.social also others not on here) have a paper out studying the origins of widely observed gene-environment correlation for educational outcomes. Paper: rdcu.be/dv1sp let me walk you trough it in a thread 1/?

A beautiful study by @michelnivard.bsky.social et al. on the direct and indirect genetic effects on school achievement shows that the indirect effects act primarily via dynastic effects rather than genetic nurture. www.nature.com/articles/s41...

Some more SEM madness by us showing that a general factor of grey-matter integrity across ROIs is associated with a general factor of cognitive ability in an old sample. Check out if you are not afraid of path diagrams. www.sciencedirect.com/science/arti...

Family-based GWAS have become the gold standard for assessing causal genetic effects. They’re often said to offer an unbiased estimate of the average causal effect (ATE) of an allele or PGS. Here, we (Carl Veller & @mollyprz.bsky.social ) evaluate such statements. www.biorxiv.org/content/10.1... 1/n

🧬 Exciting Updates in Genomic SEM Package!🧬 We're thrilled to announce that two incredible new functions are now available in the Genomic SEM package. Let's dive into what these functions do and where to find tutorials for them.🧵👇

Preprint is up now www.biorxiv.org/content/10.1...

I wrote a long (and presumably spelling error riddled) blog post with my impressions of #WCPG2023 and the state of psychiatric genetics.