We're excited to have a great speaker line up for our 6/17 talk! @samaritanshope.bsky.social #SuicidePrevention #SuicideResearch #GriefSupport #SuicideLossSurvivor Register for FREE today 👇👇 bit.ly/4myP4s4

New preprint! We investigate the risk of algorithmic bias (across race/ethnicity, gender, and their intersection) in machine learning models predicting suicide attempts across 3 clinical settings in over 1.2 million patients. osf.io/preprints/ps...

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...

4/4 A HUGE 🙏thank you to the @pgcgenetics.bsky.social working groups and participants and amazing co-authors, with special shoutout to Josefin Werme, Wouter Peyrot, Alex Frei, Christiaan de Leeuw, Lucy Bicks, Ken Kendler, and @jorsmo.bsky.social. This work reflects collaboration at its best ❤️🧬

Another great post from @sashagusevposts.bsky.social "The mystery of twin heritability comes to an ignoble end: no massive tranche of rare variants, no phantom interactions, just inflation." theinfinitesimal.substack.com/p/the-missin...

***3 days left to sign up for our virtual conference on Precision Psychiatry*** +CME +free for students and trainees. Featuring an amazing line-up of speakers.

New article written by Heather Stringer about precision treatment work in the mental health space by Kate Bentley, Ellen Driessen, @jorsmo.bsky.social, Leanne Williams, Conor Liston, and others www.apa.org/monitor/2025...

Ending the federal LGBTQ+ suicide prevention line is a public health failure www.statnews.com/2025/07/12/e... via @statnews.com

The Surprising Scientists Hit by Trump’s D.E.I. Cuts www.nytimes.com/2025/07/10/u...

Twin study suggests genetic variation influences how funny you think you are but not how funny you actually are. 😄 www.cambridge.org/core/journal...

New polygenic score resource from Mykyta Artomov and colleagues and @finngen.bsky.social "All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation." www.medrxiv.org/content/10.1...

"career staff were told not to respond in writing to panicky grant recipients whose funding had been shut off to avoid a “paper trail,” wapo.st/4kjmqsn

🆕📽️Last week's webinar is available now on YouTube! How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?... Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social

the disturbing old days of medicine and psychiatry in this episode of Medic from 1956: ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog

From back in the day when a two page research paper with no tables or references could still be transformative?

Sad to see this. I used to love these numbers when I was a kid

Reviewer #2 is now soliciting articles.

🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...

New Forbes story about the economic consequences of science cuts. www.forbes.com/sites/johndr... Thoughtful and thorough analysis. 1/n

Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research” Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...

"let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country" What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com

75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...

New work led by Yi-Han Sheu providing continuous-time and dynamic risk prediction models using Neuro-ODE with application to suicide risk prediction rdcu.be/eeIte

JAMA 100 yrs ago: "it is generally recognized that men with large heads seem to represent the intelligentsia of man, although this does not mean necessarily that a smaller headed man may not be quite as keen in his intellectual processes." Large and Small Brains jamanetwork.com/journals/jam...

We Need a Reminder of What the Pre-Vaccine Era Was Like www.nytimes.com/interactive/...

How the NIH dominates the world’s health research — in charts www.nature.com/articles/d41...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Great thread Paul. This comment in particular caught my eye--I had never thought to calculate this in planning for lab's funding but its very helpful (and daunting since this is the status quo and as you suggest, things may get much harder).

Lithium wins for treatment of bipolar depression Real-world effectiveness of pharmacological maintenance treatment of bipolar depression: a within-subject analysis in a Swedish nationwide cohort - The Lancet Psychiatry www.thelancet.com/journals/lan...

Large VA study finds GLP-1 RAs associated with reduced risk of psychiatric conditions including schizophrenia, bulimia, substance use disorders and suicidal ideation in patients with diabetes pubmed.ncbi.nlm.nih.gov/39833406/

"researchers used the model’s suggestions to change two of the Yamanaka factors to be more than 50 times as effective" www.technologyreview.com/2025/01/17/1...

Natural rafts- the exosomes of evolution? Meet The Extinct Monkeys That ‘Rafted’ Across The Atlantic Over 30 Million Years Ago via @forbes www.forbes.com/sites/scottt...

My daily calendar feels seen. urls.grow.me/U-ILwBYW-F

ABC, NBC & CBS dedicated about 16 minutes of airtime last night to the California wildfires without once mentioning climate change. Since the news failed do it's job, here's a short summary of the role of climate change and wildfire risk: www.noaa.gov/noaa-wildfir...

An inspiring scientist, leader, collaborator, and mentor: @heidirehm.bsky.social

A Scalable Framework for Identifying Allelic Series from Summary Statistics www.biorxiv.org/content/10.1...

Unsupervised Ensemble Learning for Efficient Integration of Pre-trained Polygenic Risk Scores www.medrxiv.org/content/10.1...

A novel strategy for predatory publishing? Not even remotely close to my research area and never heard of this paper (and neither has PubMed apparently...)

Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models pubmed.ncbi.nlm.nih.gov/39733260/

Fascinating analyses from @sashagusevposts.bsky.social (as usual). Of interest for cross-disorder genetics: comorbidity with genetically correlated trait can increase or decrease risk of transmission depending on correlation of their environmental risk factors open.substack.com/pub/theinfin...

Great to see this out. From @caina89.bsky.social and @pgcgenetics.bsky.social Cross-disorder group rdcu.be/d4ZF0

"what neural substrate sets this speed limit on the pace of our existence? Why does the brain need billions of neurons to process 10 bits/s? Why can we only think about one thing at a time? " The unbearable slowness of being: Why do we live at 10 bits/s? www.sciencedirect.com/science/arti...

New method for evaluating pleiotropy and genetic overlap from @andrewgrotzinger.bsky.social and colleagues Genomic network analysis characterizes genetic architecture and identifies trait-specific biology www.medrxiv.org/content/10.1...

Moving profile and hope for translating genetics to much needed treatments www.wsj.com/health/healt...

Looking forward to our upcoming webinar from @csrp.bsky.social on #machinelearning - based models for #suicideprevention Registration can be found here csrp.mgh.harvard.edu/webinars/

Mixwas: a one-shot, lossless algorithm that efficiently integrates distributed EHR datasets via summary statistics www.medrxiv.org/content/10.1...