First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Not all pathogenic variants are in coding regions! 👀 📢 This review highlights Mendelian disease-causing UTR variants, their mechanisms, and implications for clinical interpretation. 🧬 #Mendelian #UTRvariants #ejhg www.nature.com/articles/s41...

A key (too often ignored) aspect of Alzheimer's research is translation of findings between familial disease, specialist clinics, and general population. In this piece we identify key unanswered research questions and describe a framework for knowledge integration. www.nature.com/articles/s41...

I'm looking for a PhD student to do some trailblazing at the frontier of personality genomics and lifespan gene-environment transactions (start Fall 2026)! If you want to work with me: psychology.msu.edu/graduatestud... (PS @drmeltemyucel.bsky.social is taking a student too, in moral psych/dev!)

Super cool study looking at understanding age-dependent impacts on genetic variance!!

Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!

New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...

What evidence do we have on the Social Determinants of Dementia (SDOD)? Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified... doi.org/10.1002/alz.... 1/

Nature research paper: Structural variation in 1,019 diverse humans based on long-read sequencing go.nature.com/3GI9EWC

Differences in physical, social, and sociopolitical factors across the world have resulted in marked disparities in healthy ageing across countries, according to an analysis in Nature Medicine. go.nature.com/3UfJ8GU #medsky 🧪

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

ICYMI: New online! Translating lifestyle interventions for optimal brain health in Africa

In a large-scale proteomic study of biological aging of 11 organs, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity, according to a paper in Nature Medicine. go.nature.com/44nLb1M #medsky 🧪

Bell et al. report that multisite chronic pain, unlike single-site, in older adults is linked to faster cognitive decline and increased AD pathology, particularly in APOE-ɛ4 carriers. This supports multisite pain as a risk factor for AD dementia. Read at buff.ly/tXL0Qro @TylerBellPhD

Preprint alert! 🚨 doi.org/10.1101/2025... Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social! We present several great results, and I’m thrilled to highlight the pieces I worked on:

📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co! Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1... The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!

External link live! Please share widely :-) WE ARE RECRUITING! 🥳 Are you an epidemiologist with strong quantitative skills and an interest in contributing to exciting research into the genetic architecture of vascular dementia? Come join our friendly and productive team at UCL! shorturl.at/aZ5Ua