🚨In this new systematic review in BMJ JECH, most of the 18 studies reported dynamic associations between lifecourse socioeconomic change and dementia risk. Highest risk for those born poor who stay poor. Eleanor Williams, @ilk21.bsky.social , Carol Brayne @cph.bsky.social

"Interventions that reduced socioeconomic inequalities were those implemented and enforced across entire populations/systems or... were supportive and tailored to the differing needs of individuals across socioeconomic groups in their design and delivery." bmjpublichealth.bmj.com/content/3/2/...

Now on YouTube: Our Dementia Research Salon Livestream recording exploring #Dementia Risk Reduction - guest host Luis Tojo speaks with @sebwalsh.bsky.social, @simonesalemme.bsky.social & @timothydalyalz.bsky.social on prevention, policy & population health youtu.be/E12QCc5uWek

Increases in social media use throughout early adolescence significantly associated with [small] lower performance in specific aspects of cognitive function Social Media Use Trajectories and Cognitive Performance in Adolescents jamanetwork.com/journals/jam...

A privilege to represent the population health perspective, alongside Carol Brayne @cph.bsky.social , in this new @thelancet.com Series on #Alzheimer's disease. Expertly led by Giovanni Frisoni Alzheimer's disease outlook: controversies and future directions www.thelancet.com/journals/lan...

Out of 800+ studies on blood-based biomarkers for Alzheimer's, not a single one measured actual changes in patient outcomes. doi.org/10.1136/bmj-...

A key (too often ignored) aspect of Alzheimer's research is translation of findings between familial disease, specialist clinics, and general population. In this piece we identify key unanswered research questions and describe a framework for knowledge integration. www.nature.com/articles/s41...

Nice write-up of the RETREAT-FRAIL trial from @nejm.org paper by John Mandrola in the Sensible Medicine substack www.sensible-med.com/p/evidence-t... (Paper: www.nejm.org/doi/full/10....)

New paper with Janet Janbek using 🇩🇰 registry data to examine prevalence/co-occurrence of dementia risk factors. 82% of people >65 have multiple risk factors, speaking to the need for upstream public health action. More work soon from this collaboration! www.sciencedirect.com/science/arti...

We assume that the built environment affects how active we are but solid evidence lacking. Important paper from 🇺🇸 using📱data to show moving from less walkable neighbourhood to more, or vice versa, has meaningful effect on activity, sustained 3 months after moving www.nature.com/articles/s41...

What evidence do we have on the Social Determinants of Dementia (SDOD)? Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified... doi.org/10.1002/alz.... 1/

Making social sciences foundational to academic medicine - putting the 'social' into 'social determinants of health'. dx.plos.org/10.1371/jour...

Adherence to four dietary indices and the risk of all‐cause and cause‐specific dementia: Findings from the UK Biobank study - Carrasco‐Marín - Diabetes, Obesity and Metabolism - Wiley Online Library dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

Dementia and the disappearing subject: a framing analysis of drugs for dementia in UK news media doi.org/10.1016/j.ss...

Analyses from Sweden suggesting that cognitive reserve is really rooted in early life, with limited opportunity therefore to affect this in adulthood. Supported by findings from the 1946 birth cohort in the UK doi.org/10.1002/alz....

Issue with PAFs for dementia are that we could never actually achieve risk factor eradication So, in 🇳🇿 , Etu Ma'u has led modelling of 15-25% reductions in risk factors (still ambitious) and shown meaningful PIFs over time, esp for Maori and Pacific peoples doi.org/10.1002/alz....

Delighted to see the final paper from my PhD published in BMJ Public Health. A scoping review of dementia primary prevention policies in England: do they balance reach and agency? 1/ bmjpublichealth.bmj.com/content/3/1/...

>10 years old but still as relevant - 10 tips for progressing from PhD to PI from @martinwhite33.bsky.social fuseopenscienceblog.blogspot.com/2012/05/from...

Next up is Prof Ngaire Kerse with a lot of great updates on what's happening in Aotearoa for dementia care and population level risk reduction. Look @sebwalsh.bsky.social it's your equali-tree! #ANZSGM2025

A couple of months ago in @bmj.com (I’m that far behind!). This is something we should care about. We need a medical workforce that is diverse and who can relate to patients and others in the MDT.

Interested in how we lower the population's risk of developing? Check out the refreshed webpages of our research group, including an up to date Evidence Hub. Interested in learning more? Get in touch! coghealth.net.au/population-b...

The Limited Role of Alzheimer Disease Blood-Based Biomarkers in Primary Care jamanetwork.com/journals/jam...

V important paper from Sarah and team on external validity of cognitive assessment studies. Non-response in cognitive studies is not random - people not taking part are older, have lower cognition, and reduced functioning. Must weight analyses! alz-journals.onlinelibrary.wiley.com/doi/full/10....

In population-based study (Kungsholmen), NPVs high but PPVs for blood based biomarkers 30% for single biomarkers, 45% for combination. Median follow-up 10 years. Just can't see how screening could ever be feasible with these kinds of values www.nature.com/articles/s41...

In this Chinese population-based sample, we found that health behaviours were more strongly linked to living longer without getting dementia, compared to APOE e4 genotype. Though we didn't see any compression of the dementia morbidity (once it occurred) doi.org/10.1002/alz....

Shingles vaccination programme in Wales appears to be associated with reduction in dementia risk. Healthcare records aren't a perfect way of capturing dementia incidence but this is a potentially important finding rdcu.be/egagG

Systematic review of MCI prognosis from @simonesalemme.bsky.social population-based samples show almost half the conversion rate, and more than double the rate of reversion to normal cognition, compared to clinical samples. alz-journals.onlinelibrary.wiley.com/doi/full/10....

In this relatively affluent sample, social support seemed to mitigate SDOH relationship with dementia for men but not women Social determinants of health and risk of dementia among older men and women: A 12‐year cohort study in Australia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Excellent summary of our recent study from Naaheed Mukadam @ucl.ac.uk and @nihr.bsky.social Population-level policies on risk factors for dementia could reduce costs evidence.nihr.ac.uk/alert/popula...

Dear Outlook: my mailbox would be a lot less full if you stopped emailing me to tell me how full it was 🙃

Changing story of the dementia epidemic jamanetwork.com/journals/jam...

Reality check on AD biomarkers from @cdufouil.bsky.social at DPUK conference In MEMENTO, minimal variability of BBMs explained by clinical factors. And BBMs add little predictive ability beyond standard demographic/neuropsych tests What happens when outcome = people instead of PET scans!

Join us online or in-person for this @alzresearchuk.bsky.social East open meeting for the #CambridgeFestival next Friday at the University Centre (or online). I'll be talking on population-level approaches to dementia risk reduction www.eventbrite.co.uk/e/alzheimers...

Living in poverty in childhood increases the likelihood of poverty in adulthood But it's not inevitable, and some countries (Denmark, Germany, Oz, UK) are much better than others (USA) at reducing this 'intergenerational transmission of poverty' www.nature.com/articles/s41...

Are you interested in policy action to reduce population dementia risk? A reminder to join us online for these three, free expert talks and Q&A starting at: NZ = 27th Feb 9am UK = 26th Feb 8pm EST = 26th Feb 3pm www.eventbrite.com/e/public-lec...

7 year follow-up from SPRINT trial: intensive vs standard blood pressure treatment for 3 years in high-CVD risk people resulted in a lower risk of MCI and cognitive impairment ?Underpowered for probable dementia as a solo outcome measure www.neurology.org/doi/10.1212/...

We already see the shutdown's cost. Kids with drug-resistant TB, turned away from clinics, are not just dying - they're spreading the disease. People around the world w HIV, denied their medicine, will soon start transmitting virus. The damage is global.

Population-level interventions like salt reduction programmes have an important role in protecting our 🧠 as we age, by reducing stroke and dementia risk from hypertension. And if done gradually, people don't notice the difference in taste! jamanetwork.com/journals/jam...

At some point we have to ask whether these sports, in which the aim is to punch someone else in the head enough times that they are no longer conscious, can continue to exist despite so much evidence that it can kill, and increase risk of dementia www.bbc.co.uk/sport/boxing...

Various re-hashings of v small treatment effects of AD MABs to persuade regulators of meaningfulness My heuristic: if it's debatable, it's probably not meaningful. If asserted through post-hoc re-framing, it's almost certainly not meaningful! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

No ⬇️ in dementia incidence across MAPT and preDIVA trials despite some risk factor improvements We won't make big (any?) dents in dementia incidence, a complex syndrome for which risk develops across lifecourse, through individual lifestyle interventions. Must think bigger! doi.org/10.1002/alz....

More recent generations of older people are reaching old age with greater intrinsic capacity (in better knick). Something to be celebrated. But we also need to work out how to maintain these trends, and reduce inequalities within them, moving forwards www.nature.com/articles/s43...

So excited for this event on Population-Level Approaches to Dementia Risk Reduction (PLADRR) in Feb. Hybrid talks from Carol Brayne, me, and Etu Ma'u. Free! Link below! Join us! 🇳🇿 27th Feb 9:00 🇬🇧 26th Feb 20:00 🗽 26th Feb 15:00 www.eventbrite.com/e/public-lec... www.eventbrite.com/e/public-lec...

Very significant study in Nature Medicine from the ARIC study team 42% lifetime risk of dementia at age 55. Higher than previous estimates, which they attribute to better ascertainment + more diverse sample Median age of dementia 81, sex difs show only after 85 www.nature.com/articles/s41...

Comparison of PAFs, PIFs, and national and subnational population-level policies, for dementia risk reduction in 🇮🇹. A tour de force of a paper from Simone Salemme and colleagues www.sciencedirect.com/science/arti...

We need to more in the dementia field to integrate into the broader NCD prevention agenda. And the NCD prevention agenda needs to do more to be inclusive of late-life diseases Dementia is a neglected noncommunicable disease and leading cause of death doi.org/10.1038/s415...

Objectively this would be very, very funny. If only the harm she caused when she *did* crash the economy wasn't so real www.bbc.co.uk/news/article...

Text message reminders with or without nudges, with or without chatbots, had no effect on adherence to chronic CVD meds. Nice trial showing that simple answers to complex problems don't work! jamanetwork.com/journals/jam...