At @5PrimeSciences, giving back is part of who we are. This year, our team chose to support @MSF —to deliver critical medical care in humanitarian crises. We’re proud to have joined the Pledge 1% Movement, committing 1% of our profits each year to health and education charities

Our paper out in JCEM showing bias that can creep into Mendelian randomization studies via: 1. Collider bias due to participant selection 2. Indirect genetic effects 3. Collider bias due to GxE effects in nonlinear MR. Led by the great Tianyuan Lu academic.oup.com/jcem/article...

Join us today at 4:40 pm at the Festival of Genomics & Biodata (@fogenomics.bsky.social) in Boston to explore how proteomics and genomics drive drug-target discovery!

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

Come join 5Prime as we grow our team to use human genetics and other —omics to accelerate drug development. New post for a Software Engineer: 5primesciences.com/careers/

The Big Five personality traits definitely have clear genetic determinants. I'm surprised by the lack of spousal assortment and lack of shared environmental confounding though...Anyone care to guess why this is the case? www.biorxiv.org/content/10.1...

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

After a long and storied career, Kari Stefansson exits as CEO of DeCODE Genetics. icelandmonitor.mbl.is/news/news/20...

I didn't have much hope that we'd find genetic determinants of long-COVID, but after years of work, Vilma Aho, Tomoko Nakanisha, Hugo Zeberg and Hanna Ollila made it happen! (Among a few others :-)) www.nature.com/articles/s41...

My main postdoc project is now published in @AJHG! We describe a MR estimator (Quantile IV) that does not rely on parametric assumptions and allows for heterogeneous causal effects. www.cell.com/ajhg/abstrac...

PREPRINT: Led by @j-a-mitchell.bsky.social & Babette Zemel, we show higher gSOS polygenic score associated with higher pediatric aBMD 🦴 & lower fracture risk @chopresearch.bsky.social . gSOS previously developed with ML on adults by @brent-richards.bsky.social team www.medrxiv.org/content/10.1...

There are few more engaging, creative and relentless clinician scientists than @stephenorahilly.bsky.social I enjoyed his visit to @mcgilluniversity.bsky.social and learning how he unpicked GDF15 as a cause of morning sickness.

A great scientist and clinician changes the world and brings home a well-deserved prize. www.theglobeandmail.com/canada/artic...

To the world: We are fighting back. Our movement has been silenced by the media here—but we are not backing down. This is what our streets looked like across multiple cities. Tomorrow, there will be more of us! Raise a glass to freedom. —With love, Your American allies.

And Kevin Liang successfully defended his PhD examining the use of human genetics to identify drug targets! Well done Dr. Kevin

Does vitamin D prevent MS onset? We have predicted this for years using Mendelian randomization. Here, high-dose vitamin D, in individuals with Clinically Isolated Syndrome in the D-Lay trial is perhaps encouraging. jamanetwork.com/journals/jam...

An excellent visit from @mendelrandom.bsky.social in Montreal this week. He wants to change Mendelian randomization to "meiotic randomization"—likely a much better name. But what would we call @mendelrandom.bsky.social ?

Even the @wsj.com thinks Trump's tariffs are, "the dumbest in history". www.wsj.com/opinion/trum...

That's right

Is there a German word for being simultaneously horrified by clumsy, misguided, and deeply destructive attacks on a critical system, and by the many grossly dysfunctional and inefficient aspects of the system being attacked? Because we really need one right now.

Come and join our research lab at @mcgill University as a Research Associate! If you're excited about using genomics and other omics to understand causes of disease, send me a direct message or check out the position here: www.mcgill.ca/genepi/oppor...

If you wanted to decrease the cost of homes, one thing you wouldn’t do is put a flat tariff on your main source of timber.

Can human genetic evidence can improve drug development success? The latest @hggadvances.bsky.social article by @brent-richards.bsky.social & co. uses IntAct, a protein interaction database, to explore this question: www.cell.com/hgg-advances... #ASHG #HumanGenetics #GeneticsDiscoveries

Hopefully we'll see less fentanyl in our emergency rooms and less homelessness. @VertexPharma gets approval for the first new class of pain medicine in 20 years. Genetic variation in NaV1.8 helped to identify this target. news.vrtx.com/news-release...

📣Excited to share our paper in Nature Genetics! rdcu.be/d7mo0 Do plasma proteins mediate obesity’s effect on CAD risk? →Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin, cleaved from COL6A3, as a mediator & potential therapeutic target. A 🧵↓

I see lots of patients with obesity who develop heart attacks. Often they have normal cholesterol, blood pressure and glucose levels are normal. So why do they get heart attacks? We identified endotrophin as a mechanism whereby obesity causes heart disease. 🧵 www.nature.com/articles/s41...

Here we describe the role of endotrophin in cardiovascular disease. Great work from @SatoshiYoshiji and others.

Excited to announce our 17th team member to @5PrimeSciences Kelly Agnew joins us as a Senior Software Engineer to help us build Centromere, our data and analytics engine for genetics-enabled drug development. Welcome Kelly!

In another home-run for genetics-enabled drug development, APOC3 inhibition is approved to treat a disease of hypertriglyceridemia. 👇 www.science.org/doi/10.1126/.... Human genetics identified the target in 2008, thanks to work done in the Amish population. 👇 www.nature.com/articles/s41...

This seems quite common across biology, whether its crispr perturbations www.cell.com/cell-genomic... or enhancers www.nature.com/articles/s41... or splicing elifesciences.org/articles/59959 or tf binding academic.oup.com/nar/article/... or ecology www.cell.com/cell/fulltex...

Bit of a standard moan - “epigenetic association studies” are *very* hypothesis / model different vs GWAS (genotype association studies) even though the process v similar (put DNA on arrays, call alleles/epi-alleles, do association with covariates). *completely* different

Humans tend to inherently believe that context matters. But context doesn’t seem to matter all that much in genetics. Epistasis between mutations doesn’t seem to influence their stability in this amazing saturation mutagenesis paper. www.nature.com/articles/s41...