Marc-André Legault
@legaultm.bsky.social
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Genetic epidemiology and pharmacogenomics research, U de Montréal
My main postdoc project is now published in @AJHG! We describe a MR estimator (Quantile IV) that does not rely on parametric assumptions and allows for heterogeneous causal effects.
www.cell.com/ajhg/abstrac...
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A flexible machine learning Mendelian randomization estimator applied to predict the safety and efficacy of sclerostin inhibition
Mendelian randomization (MR) enables the estimation of causal effects while controlling for unmeasured confounding factors, but MR estimators often rely on strong parametric assumptions. We propose an...
https://www.cell.com/ajhg/abstract/S0002-9297(25)00171-5
4 months ago
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Marc-André Legault
Yves Brun lab
7 months ago
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at
@umontreal.ca
and
@mila-quebec.bsky.social
. Apply to
[email protected]
. See
lnkd.in/dVVk4N3s
.
#microsky
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Join us at UdeM and CHU Sainte-Justine! The bioinformatics community at Sainte-Justine is growing, and our clinician colleagues are really great.
add a skeleton here at some point
7 months ago
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Marc-André Legault
Mann Lab
7 months ago
Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics
#pQTL
First author
@liliniu.bsky.social
explains ⬇️
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Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics
This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.
https://nature.com/articles/s41588-025-02089-2
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Marc-André Legault
Tom Soare
8 months ago
Excited to share a new paper from
@insitro.bsky.social
(first author
@zmccaw.bsky.social
) in
@hggadvances.bsky.social
vances.bsky.social
on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS.
www.cell.com/hgg-advances...
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Pitfalls in performing genome-wide association studies on ratio traits
Any variant associated with either numerator or denominator will associate with the ratio in GWAS of sufficient size. Associations with ratio traits are thus not specific to the ratio. Instead, we rec...
https://www.cell.com/hgg-advances/fulltext/S2666-2477(25)00009-0
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Marc-André Legault
Jason Moore
9 months ago
I used to put our open-source software on business card-sized CD ROMs & pass them out at conferences. We had code, sample data, & PDFs on the disk.
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Marc-André Legault
10 months ago
Dear early career genetic epidemiologists: The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world. Apply here by Dec 31st:
www.geneticepi.org/yic_position...
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Marc-André Legault
Chen-Yang Su, MSc
10 months ago
🚨NEW PREPRINT! Interested in Mendelian randomization and proteomics? 🧬 We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries! Preprint:
www.medrxiv.org/content/10.1...
Website:
broad.io/protein_mr_a...
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