Jonathan Mitchell
@j-a-mitchell.bsky.social
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Associate Professor of Pediatrics at UPenn and CHOP | wearables | data science | sleep | nutrition
reposted by
Jonathan Mitchell
Struan Grant
11 days ago
Delighted to contribute to this review of the genetics of obesity, just out in
@natmetabolism.nature.com
, led by Amélie Bonnefond and Philippe Froguel.
@chopresearch.bsky.social
@penngenetics.bsky.social
www.nature.com/articles/s42...
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The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism
This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...
https://www.nature.com/articles/s42255-026-01497-w
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reposted by
Jonathan Mitchell
Struan Grant
6 months ago
Just out: Led by
@j-a-mitchell.bsky.social
and Babette Zemel "gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood"
@asbmr.bsky.social
. Funded by our
#NICHD
award R01 HD100406.
@chopresearch.bsky.social
@penngenetics.bsky.social
academic.oup.com/jbmr/article...
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The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood
Abstract. The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of Europ
https://academic.oup.com/jbmr/article-abstract/doi/10.1093/jbmr/zjaf149/8285752
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reposted by
Jonathan Mitchell
Juliette Brook
11 months ago
Dreaming of a dataset that tracks mood, sleep & activity to better understand affective instability (AI)…AND paired with advanced MRI? 🤯 Check out our new bioRxiv preprint for a 13–23 y/o community sample (n=10 and growing!) with multi-echo fMRI, EMA & actigraphy:
www.biorxiv.org/content/10.1...
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reposted by
Jonathan Mitchell
Struan Grant
11 months ago
PREPRINT: Led by
@j-a-mitchell.bsky.social
& Babette Zemel, we show higher gSOS polygenic score associated with higher pediatric aBMD 🦴 & lower fracture risk
@chopresearch.bsky.social
. gSOS previously developed with ML on adults by
@brent-richards.bsky.social
team
www.medrxiv.org/content/10.1...
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The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood
The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fractu...
https://www.medrxiv.org/content/10.1101/2025.04.22.25325387v1
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