Roughly half of common disease heritability is pleiotropic across diseases, with shared variance 1.51x enriched in the genetic component. Work led by Yujie Zhao (co-supervised by Alkes and me) is now out in @natgenet.nature.com www.nature.com/articles/s41...

Huge congrats to @xilinjiang.bsky.social (Wellcome fellow in the group) on his first senior author paper, in @natgenet.nature.com no less! 👏👏👏👏 Pleiotropic shared heritability quantifies the shared genetic variance of common diseases www.nature.com/articles/s41...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)