JAX Long-Read Sequencing Workshop Keynotes by @aphillippy.bsky.social & @mydennis.bsky.social Co-organized by @olgaanczukow.bsky.social, @christinebeck.bsky.social & Mark Adams ✈️ Trainee travel awards 📝 Abstracts due March 3 🥼 Optional wet-lab training session 🔗 www.jax.org/education-an...

Please check out these amazing women! They are fantastic scientists, committed mentors, supportive friends and honestly super stars! 🤩@bradylabs.bsky.social @mydennis.bsky.social @ucdavis.bsky.social www.ucdavis.edu/news/podcast...

Anyone in the U.S. got an ERK biosensor zebrafish line they'd be willing to share/ship to VA? vascular specific would be preferred, but I'll take global too. @zebrafishrock.bsky.social

Recently learned that I will be promoted to FULL PROFESSOR(!) this coming summer. So happy and thankful for those that have supported me along the way, including collaborators, mentors, colleagues, friends, family, trainees, and letter writers. #bighugs #youdabest #firstgen

Please repost and share widely - winter break is a perfect time to assemble application materials 😅

Did you know the last common ancestor of #zebrafish and humans was ~450 million years ago? A whole genome duplication event (3R) occurred early in the teleost fish phylogeny. Despite this event, zebrafish and humans have about the same number of chromosomes. #ZebrafishFunFacts 🧪

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

CiFi: accurate long-read chromosome conformation capture with low-input requirements. #HiFi #LongRead #Sequencing @natcomms.nature.com 🧪🧬 🖥️ www.nature.com/articles/s41...

Consider applying for the Robert E. Chason Endowed Chair in Translational Research at the UC Davis MIND Institute! Join a vibrant community of colleagues studying neurodevelopment conditions like autism. UC Davis is an excellent place to work and live. Find more details here: lnkd.in/gZRyViNa

Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...

Lab ice skating and winter party ❄️⛄️

Very happy to share that I’ve been awarded a K99 Career Development Award from NIGMS for my work on MSH2-MSH6 and its role in recombination-mediated rearrangements. Big thanks to my mentor, Wolf Heyer, co-mentor, Megan Dennis, letter writers, and colleagues. mmg.ucdavis.edu/news/two-mmg...

Join us at this exciting Workshop on #LongReads with keynotes from @aphillippy.bsky.social @mydennis.bsky.social co-organized by @christinebeck.bsky.social and Mark Adams @jacksonlab.bsky.social Register www.jax.org/longread #RNA #genomics #bioinformatics #cancer #medicine #evolution #neuroscience

The lab is coming out strong with their "fishman" pumpkin-contest submission this year for the Halloween Symposium today @ucdgenomecenter.bsky.social ! Pumpkin credit: @nicholashaghani.bsky.social 👻🎃

😆

Excellent review from @silparacchini.bsky.social’s lab with a nice bluetorial

Happy to share a new @biorxivpreprint.bsky.social from the lab, led by talented postdoctoral fellow #MinhooKim: "Single-cell exploration of ovarian aging across vertebrate models", a meta-analysis study of public ovarian aging sc/snRNA-seq data! www.biorxiv.org/content/10.1... A 🧵, 1/5 🧬🖥️🧪 #GeroSky

We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open. We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting. 🗓️ Deadline: October 15th More information: smbe2026.org/symposia #SMBE2026

Really cool, conceptually simple approach here: cross-referencing grant proposal scores with literature citations and explicit acknowledgments in drug patents to identify patents linked to projects that wouldn't have been funded given a smaller budget

While I'm sad our cover submission wasn't selected for our recent human duplication paper, check out the super cool illustration created with @lazaroillustration.bsky.social ! Certainly, you will be seeing Dennis lab members running around with "fishman" t-shirts at future meetings, inspired by Ohno

Lab outing 😍

Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

Jasmin Rees PhD chapter as a paper just out at the AJHG @ajhgnews.bsky.social, with Sergi Castellano, who first envisioned the study. Jas investigated signatures of human local genetic adaptation in hundreds of micronutrient-associated genes.

Privileged to have had the opportunity to advocate for biomedical research funding in #Congress yesterday! It was an honor to represent the @geneticssociety.bsky.social alongside my amazing colleagues @gregorylab.bskyverified.social and #JillFahrner! 🔬 🧠🧬 #ASHG #Genetics #ResearchMatters

A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n

Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪

In work led by @lalli.bsky.social, we present recombination maps and a diverse haplotype reference panel (1000 Genomes Project) for the T2T-CHM13 human reference genome. These resources improve the accuracy of phasing and imputation, especially around common CNVs. www.biorxiv.org/content/10.1...

Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...

So excited to see this paper out in Cell from the group of my good friend @mydennis.bsky.social It's been so exciting to see this story progress progress. www.cell.com/cell/abstrac...

Thrilled that our study on human gene duplications and brain evolution is out! It was a true labor of love, with special shout-outs to my co-first author @jmuribescr.bsky.social and my PhD mentor @mydennis.bsky.social. Huge thanks as well to @aidaandres.bsky.social for all the popgen wisdom!

Thrilled to see this story out today! Such a fascinating topic with lots still to discover 🥳

Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...

Omg I’ve never laughed so hard in my life. Tonight my husband set out a fly trap in our backyard. The kind that smells like dead animal and poop to attract flies. Shortly after, we get these emails on our neighborhood listserv. Coincidentally, we had put out a fly trap a couple weeks ago too 👀

"Writers have been using me long before the advent of AI. I am the punctuation equivalent of a cardigan—beloved by MFA grads, used by editors when it’s actually cold, and worn year-round by screenwriters. I am not new here."

How bats developed their wings? 🦇 Turns out they reutilize existing gene programs 🔧 Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs www.nature.com/articles/s41...

#Zebrafish folks, don’t leave #IZFC2025 just yet! The most fun session is still to come… Excited to present with @param-p-singh.bsky.social, @mydennis.bsky.social, Hannah Grunwald, Yansong Lu, and Ji-Feng Fei. See you there! @izfs.bsky.social #EndlessFishMostBeautiful

Absolutely stunning work - tour de force. www.science.org/doi/10.1126/... Structural and genetic determinants of zebrafish functional brain networks | Science Advances

BMC Biology is currently welcoming submissions of original research to the “Genome organization and evolution” Collection, which I am supporting as a Guest Editor. If interested check out the link: www.biomedcentral.com/collections/... #GenomeEvolution @bmc.springernature.com

Congratulations to the 2025 George Streisinger Award Winners! And, thank you, to your contributions to the #zebrafish field! #IZFC2025

If you are interested in this position and attending #IZFC2025, let’s grab a coffee and chat. @izfs.bsky.social

🧪 After the workshop on 7/7, the FDA and NIH are asking for public comments on implementing novel methodologies and other strategies to reduce the use of animal testing by 7/14: www.fda.gov/news-events/...

Forty years after Svante Pääbo kicked off this extraordinary field of science, today sees report of the first whole-genome sequence of an ancient Egyptian (from 2855–2570BCE). Exciting work from @pontus-skoglund.bsky.social, @flinklinus.bsky.social, & co at @ljmuofficial.bsky.social, @crick.ac.uk.🧬🧪

🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here: tol2kitkwan.genetics.utah.edu Thank you for your patience!! #zebrafish #transgenesis #plasmids #sharing

Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers

The lab celebrated 10 yrs since we started at UC Davis! ⭐