The #cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. New study from Kaitlyn M. Shen, Parisha P. Shah, Rajan Jain @pennmedicine.bsky.social and colleagues: rupress.org/jcb/article/... #Chromatin #epigenetics #Disease #lamin #laminopathies

The entire 1983 Stevie Ray Vaughan ACL concert has been uploaded. I've queued it up to start on "Tin pan Alley," but the whole thing is worth watching --- after you "like" this post, of course. 😃 youtu.be/MrbAaQ3BXgA?...

A Cytosine Deaminase–Based Genomic Footprinting Assay (cFOOT-seq) for Detecting Transcription Factor Occupancy Work by Meng-Chen Yang, Ang Wu, Heng Wang, Xiaoyu Liu, Jiejun Shi, Shaorong Gao and Jia-Min Zhang at Tongji University. #LifeSciences #Reproducibility #MolecularBiology

Submit to our Developmental Biology Special Issue - Receptor tyrosine kinase signaling in development!😎 Guest editors Katherine Fantauzzo @fantauzzolab.bsky.social Jennifer Fish Deadline April 30th, 2026 @socdevbio.bsky.social Linked here👇 www.sciencedirect.com/special-issu...

NIH Fellowship awards for FY2025 by race drugmonkey.wordpress.com/2026/03/19/n...

Looking forward to a great talk from UVA BME alum Dr. Monica Lee @navbo.bsky.social !

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

Fun, but snow filled/delay riddled trip (on both ends) to visit with folks at the Montreal Heart Institue to talk about vascular anomalies. Great talks with faculty, students, and postdocs and some fantastic questions/ideas.

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

We've added two gnomAD coverage tracks on human hg38: gnomAD v4 Exome Coverage — mean/median depth & sample % at 1X–100X thresholds across exome samples. gnomAD v3 Genome Coverage — same metrics for 71,702 whole-genome samples. Learn more at: genome.ucsc.edu/gold...

Joshua noted that the number of applications in the data NIH released includes only applications that were discussed at study section. This is approximately 50% of the applications submitted. I have estimated these numbers in a slightly more sophisticated way, but these are still estimates. 2/25

Homicide is the 3rd-leading cause of death among American Indian/Alaska Native women and girls between the ages of 10 and 24, and fifth-leading cause of death among women between 25 and 34 years old. Learn more about the statistics of MMIWG in Alaska here: www.alaskasnewssource.com/2025/04/05/i... 🧵

“We can’t afford cancer research but $11 billion for one week of an absurd war is fine” is a hell of an argument

Preprint: A proteocistromic atlas of 216 human disease-relevant transcription factors www.researchsquare.com/article/rs-8...

DC pulled off a ridiculous weather flip: 86 Wednesday to as low as 33 with snow today. 53-degree drop is largest 24-hour fall on record at National. 77 today & 86 Wed are warmest same and prior day to snow accumulation, too. Dulles also joined the history book with combo. More: cwg.live ❄️🔥

Brent Pedersen, Mitchell Vollger and I have "posted" our preprint of the manuscript describing bedder, a complement to the functionality of bedtools. The "preprint server" we have chosen is google docs because it was rejected by biorxiv. docs.google.com/document/d/1...

In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9 https://www.biorxiv.org/content/10.64898/2026.03.11.710960v1

We just sent the March edition of our newsletter out to more than 1350 subscribers! It covers our next webinar (which we are very very excited about), city and county budgets, IMPACT’s Nehemiah Action, opportunities to walk/run/bike/roll through Cville, and more! mailchi.mp/livablecvill...

Very sad news: Becky Burdine's 20-year old daughter Sophie passed away suddenly on Tuesday Becky has been vocal about Sophie, is an @angelmanfoundation.bsky.social advocate, and wants her science/cilia/LR community to know We love you @rburdine1.bsky.social www.matherhodge.com/obituaries/S...

#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 5 sdbonline.org/gethired

NIH FY2025 funding data finally emerges on RePORT drugmonkey.wordpress.com/2026/03/06/n...

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Fascinating account of trying to find a cure for frontotemporal dementia (FTD): great advances in our understanding of one variant (mutations in GRN resulting in TDP43 proteinopathy) but no success yet with respect to treatment. www.science.org/content/arti... #medsky

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @science.org @washumedicine.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

4 corporate Democrats funded by AIPAC voted with MAGA to let Trump continue to wage illegal war on Iran.😐 •Henry Cuellar: 202-225-1640 •Jared Golden: 202-225-6306 •Greg Landsman:202-225-2216 •Juan Vargas: 202-225-8045 Call & remind them we reject their complicity in fascism Jeffries should resign.

awesome @navbo.bsky.social webinar today from Dr. Sarah Sheppard at the NIH on lymphatic malformations!

$1B per day and $4B so far of your tax dollars to kill 1000 people in 4 days And they are just getting warmed up Let that sink in

New preprint out! In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

There are two meetings this Wednesday evening you should consider attending. First, at 6pm at Lane Auditorium the Albemarle County Board of Supervisors will be hear the FY 27 budget proposal, followed by public comment. We encourage you to show up and request more funding for affordable housing.

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

LRSomatic: a highly scalable and robust [Nextflow] pipeline for somatic variant calling in long-read sequencing data www.biorxiv.org/content/10.6... 🧬💻🧪 github.com/intgenomicsl...

What would you think if a hypothetical biology professor at a hypothetical public university in a state starting with an N, who was involved in helping organize a Stand Up for Science Rally this week, and got a visit from their hypothetical Department chair and... 1/2

AAV9 is now available through Addgene's Packaged on Request service. With 4,000+ eligible cargo plasmids available, what would you like packaged in AAV9 for your next experiment? Learn more: https://twp.ai/4ivYPg

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...

We are happy to announce the JASPAR 2026 tracks for hg38, mm39, danRer11, galGal6, dm6, ce11, ci3, and sacCer3, which represent genome-wide predicted binding sites for transcription factors with binding profiles in the JASPAR CORE collection. More info: http://bit.ly/JASPAR...

My department at CSU Northridge is hiring a vertebrate functional morphologist! We've got a great EEB group, and we're looking for someone to carry forward a tradition of enriching organismal courses and community-engaged research. App review starts March 15 csucareers.calstate.edu/mob/cw/en-us...

Another reminder as we've crossed into the second half of February. There's still time to apply for the Neurobiology Chair position at Duke University! Just send in a letter of interest and CV by Feb 28. Love of Duke basketball is not required.

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.

It’s once again Girl Scout cookie season so it’s time for me remind everyone to please consider buying from NYC’s Girl Scout Troop 6000, which is entirely made up of girls living in NYC homeless shelters 🙏❤️

Repeat after me: Filming and documenting ICE activities and arrests is the most American thing you could do. The pinnacle of First Amendment protected action.

DHS is shutting down. Why? Because Democrats took an oath of office to uphold the Constitution and ICE is lawless and out of control. We cannot fund an agency that is murdering our citizens, tear gassing school zones, and disappearing legal immigrants.

Excited for this KRAS symposium at the NIH organized by Dr. Sarah Sheppard at the NIH. Should be a great meeting of heme/onc and vascular malformation clinicians and researchers.

Online Now: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 Online now:

Switching fields or wanting to become an expert in #zebrafish research? The @mblscience.bsky.social 2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field! Application deadline: March 2 Please spread the word! www.mbl.edu/education/ad...

Why work on a talk for a symposium tomorrow when I can PR on the hotel peloton bike?

It is absolutely outrageous that Moderna’s flu vaccine was met with a “refusal-to-file” even after their approved their protocol with FDA and carried out the trial as agreed. This vaccine works better in older adults than the current flu vaccines. apnews.com/article/mode...

$1.65M per day in DC alone. That’s approximately two NIH R01 Grant *years* burned per day. Ninety *five year* R01s projects burned in the last seven months with no end in sight. Instead of lasting scientific advance we get….what? Civil rights violations and authoritarian replacement of democracy.