𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Super cool new use of single gamete (single molecule!) genome sequencing - catching de novo mobile element insertions! www.biorxiv.org/content/10.1...

New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome. 🔗 biorxiv.org/content/10.1... A short thread (by Juliane Weller)👇

New preprint from another part of my PhD! 📝👇 Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells. By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet. tinyurl.com/mvns2ytv

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

How does life evolve to adapt to modern cities? Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation. 🧵(1/n) @science.org www.science.org/doi/10.1126/science.ady4515

The new Flex-sweep v2 is ready! We welcome feedback from users to further improve user experience and address compatibility issues that often occur given the many moving parts. Flex-sweep v2 now implements DANN from the Siepel lab. journals.plos.org/plosgenetics...

Hot off the press! Our latest work on the evolution of facultative symbiosis in stony corals, focusing on a remarkable Mediterranean species: Oculina patagonica. 🪸 🌊 #evobio #corals #coralbiology www.nature.com/articles/s41...

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

When transposons jump, genomes diverge - even in cultured cells. I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)

This suggest that telomere maintenance in sperm is more robust than in oocytes and impacts the inherited telomeres. Full paper is below. Curious to know what you think as this is a new area for us! www.biorxiv.org/content/10.1...

Our preprint, "Read mismapping from segmental duplications drives spurious trans associations," is out! We argue that both RNA and DNA read mismapping can lead to false signals in QTLs, Hi-C, GWAS, and gene co-expression. And there is a way to identify them! Link: www.biorxiv.org/content/10.1...

Excited to be presenting part of my thesis at VESS! I’ll be discussing work from my recent pre-print on gene dosage response curves. Drop by if you’ve been curious but haven’t had a chance to read it yet! www.medrxiv.org/content/10.1...

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

New preprint out with Brenna Henn, led by two fantastic grad students in our labs! www.biorxiv.org/content/10.1...

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Long-read sequencing reveals telomere inheritance patterns from human trios https://www.biorxiv.org/content/10.1101/2025.10.07.680721v1

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

Human-mediated land-use and climate change occur simultaneously, but how do they interact to shape adaptive dynamics? Super excited to share the first paper from the Kreiner lab, led by postdoc extraordinaire @rpineau.bsky.social

Please RT! Together with the fantastic @jcarnesecchi.bsky.social we are looking for a M2 student. The internship will take place primarily in her lab at IGMM with a part at ISEM (5-10min away). Don't miss this unique opportunity to mix molecular and cellular experiments with evolution. Apply!

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon. We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least). authors.elsevier.com/c/1loW-3QW8S...

In #GENETICS, @johriparul.bsky.social and Brian Charlesworth examine the consequences of the gene model for the genetic and inbreeding loads, showing how the gene model results in a slightly lower genetic load, but a much smaller inbreeding load. buff.ly/dKn1606

New work in #GENETICS from @johriparul.bsky.social and Brian Charlesworth present a gene-based model of fitness that predicts positive linkage disequilibrium between deleterious variants. buff.ly/Kr4Knk2

Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Do you know ~60% of human SVs fall in ~1% of GRCh38? See our new preprint: arxiv.org/abs/2509.23057 and the companion blog post on how we started this project and longdust: lh3.github.io/2025/09/29/o.... Work with Alvin Qin

Mutation bias in driver genes reveals the distribution of effects of oncogenic mutations https://www.biorxiv.org/content/10.1101/2025.09.25.678277v1

Exciting news! The next #PopGroup meeting will take place in Lille 🍟, France, 7–9 January 2026 – just 1 hour by train from London, Brussels, and Paris. This year, PopGroup will also host ALPHY, the annual meeting of Evolutionary Genomics. More info: populationgeneticsgroup.org.uk See you there !

Another year using @kitchensjn.bsky.social + @gcbias.bsky.social's intuitive circle plots to discuss human genetic variation in my undergrad genetics class james-kitchens.com/blog/visuali...

🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. www.biorxiv.org/content/10.1...

Pajic, @gokcumenlab.bsky.social @spit-lab.bsky.social et al. explored the evolution of saliva-related SCPP genes, observing extensive diversification of SCPP genes within mammals, driven by gene duplications and losses. 🔗 doi.org/10.1093/gbe/evaf165 #genome #evolution #primates

Pleased to announce that our #preprint on the evolutionary history of gene functions is now online at #bioRxiv! We overlayed functional annotations on the evolutionary history of ~4.5M genes from 508 species across the tree of life and found some very cool stuff! tinyurl.com/FuncEvol 🧵 1/10

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Just throwing this out there as a significant conceptual advance in the field www.biorxiv.org/content/10.1...

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis