I’ll be attending #ASHG25! I’m currently hiring for (i) a Senior Research Scientist or (ii) a Postdoc position in my lab. If you’re interested, please reach out to arrange a time to meet and discuss.

En route to Boston for #ASHG25 #ASHG2025! 👉 I'll be presenting a poster on our new work on genome-wide perturb-seq screens in primary human T cells (5049W, Wed 2.30pm) 👉 you can hear me talk about it at the Industry Education session presented by Ultima Genomics (Thu 3pm) [1/2]

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic. I did this last year and it was great to meet a whole bunch of new people, at all career stages!

Excited to be presenting part of my thesis at VESS! I’ll be discussing work from my recent pre-print on gene dosage response curves. Drop by if you’ve been curious but haven’t had a chance to read it yet! www.medrxiv.org/content/10.1...

Viruses, just wow... www.biorxiv.org/content/10.1...

Homie got 229 pairs of chromosomes www.sciencedaily.com/releases/202...

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

SINGER, our ARG inference method, is finally published and freely available online: doi.org/10.1038/s415... It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...

Why do males and females often differ in traits? The expected answer: selection. But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same

Thrilled to share the second half of my PhD work here! We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/) doi.org/10.1101/2025...

We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

Thanks! This is amazing! So the term 'Manhattan Plot' is not originally a GWAS term at all. Screenshotting the image here from a 1994 book on nuclear physics, for others who may be interested:

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.

Does anyone know who first used the term "Manhattan Plot"? Wikipedia links to a 2010 paper by Greg Gibson. I haven't yet found an earlier use, but Greg's phrasing suggests that he did not invent the term. doi.org/10.1038/ng07...

Can anyone point me to full resolution versions of these classic images from NHGRI that show the growth of GWAS from ~2006--2015? I'm looking for the timelapse versions. (I know many of you are waiting for the GWAS chapters of my free online textbook on human genetics--they are coming, but slowly!)

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

My talk from this year's probgen is finally out. Where do linear mixed models and random effects come from? They emerge from *mutations* on Ancestral Recombination Graphs.

New paper by Luke O'Connor @lukeoconnor.bsky.social and Guy Sella @gs2747.bsky.social

Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs

Have you worked with human genetics data? Consider taking this short survey to help us better understand how folks are using population descriptors! 🧬💻🧪

Super excited for #Evol2025! I will be sharing some cool work on selection in the gut microbial communities at 9:30 am on Monday in the Evolutionary Ecology I session (Parthenon 2)!! Looking forward to chatting with folks as well!

Looking forward to #evolution2025! I will be talking about how time-varying demography and selection shape the site frequency spectrum — Saturday at 4:15 pm, Population Genetics Theory IV. Come say hi if you are around!

🧵4/5 But are new pcQTLs relevant? We examined associations with GWAS for complex traits and diseases and found over 500 new colocalizations – a 34% increase over single-gene-based analyses! In fact, variants with distributed effects are more likely to be GWAS hits than those affecting just one gene

Excited to share my first PhD paper in the @sbmontgom.bsky.social lab with @tamigj.bsky.social (www.biorxiv.org/content/10.1...)! Standard QTL methods treat each gene independently. But what if a single variant regulates multiple nearby genes at once - what we call “allelic proxitropy”? 🧵 ⬇️

Congratulations Jeff! It's been really wonderful to have you in the lab! I cannot wait to see all the fantastic work that will come out of your future lab. ...and trainees, Jeff is an amazing scientist and mentor! If you ever have a chance to work with him you should seize it with both hands!

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July. We'll work at the intersection of statistical genetics, population genetics, and machine learning.

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

In any case, it’s useful to plug mechanistic models of how we think an experiment is perturbing the cell into the inputs of deep learning models. This lets us see if our deep learning model has learned a casual relationship that’s consistent with our understanding of the experimental perturbation.

How well can deep learning models predict the effect of modifying chromatin on gene expression??? Our work -- led by Sanjit Batra and Alan Cabrera when they were in @yun-s-song.bsky.social ’s and Isaac Hilton’s labs -- tries to answer this. 🧵🧬🧪 elifesciences.org/reviewed-pre...

Now published in PNAS: www.pnas.org/doi/10.1073/...

Elegant new theory on polygenic adaptation by Will Milligan, Laura Heyward, and Guy Sella.

Hi trainees! I'm at Biology of Genomes and would be thrilled to chat about your work, any questions about academia/science, and Andor. Please don't hesitate to reach out here, by email, or by shouting at me! #bog25 #bog2025

I hope to see you at ProbGen 2026 on March 25th-28th! I expect a wonderful meeting as always!

I am not sure how to do Bluesky yet, but I want to tell the world about our neighborhood NMF method. First of many collaborations with the Pelka Lab!!

Amidst all the terrible and terrifying news, so lovely to hear of @jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

Congratulations to @jkpritch.bsky.social, very well deserved! www.nasonline.org/news/2025-na...

Congratulations to the new NAS member @jkpritch.bsky.social. Was very very happy to hear the news! Exceptionally well deserved!

As a rare bit of good news, a huge congratulations to @jkpritch.bsky.social who was just elected to the National Academy of Sciences. Here's the full list.

A dragon emerges from an egg, within a nest among others waiting to hatch atop a majestic castle. The dragon is embedded with a DragonRNA, a DNA strand covalently extended with an RNA tail. Variants of precursor DNAs are backlit by a glowing polymerase within each egg,

What is epistasis? New preprint Blue-torial! (Work by the wonderful postdocs Maryn Carlson and Bryan Andrews) www.biorxiv.org/content/10.1...

a quick note on my paper with @jeffspence.bsky.social and @jkpritch.bsky.social on conditional frequency spectra, now out in a @genetics-gsa.bsky.social special issue: doi.org/10.1093/genetics/iyae210

Inside me there are two wolves. One of them has a 15 genome edits the other 20 genome edits. Neither of them is a dire wolf.

So I guess Jurassic Park in real life would be billions in VC investment and years of press releases followed by a tank containing five deformed iguanas

guest lecturing in @jazlynmooney.bsky.social's ethics class has been maybe the brightest spot in this slightly cursed year

This is so incredibly shameful. and what happened to “marketplace of ideas” and “free speech”?

Shameful. More obvious targeting of higher education to create an atmosphere of fear

Lungfish xkcd.com/3064

Distributions in Desmos just got an upgrade. Model chi-square distributions, shift & scale t-distributions, & calculate cumulative probability values within specific distribution bounds. Head to the Desmos Help Center to learn more: help.desmos.com/hc/en-us/art... #iteachmath #mathsky #statistics

📢 Thrilled to see this out, an atlas of e/sQTL across multiple tissues and diverse ancestries in 14,324 TOPMed participants: www.medrxiv.org/content/10.1... Grateful to the #TOPMed #Omics WG for giving me an opportunity to learn and contribute to this important work 🧬