For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...

Excited to share our latest research, out today in Cell (@cellpress.bsky.social) Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling. Read the paper here: doi.org/10.1016/j.ce...

"I'm very disappointed in the new pyramid that features red meat and saturated fat sources at the very top, as if that's something to prioritize. It does go against decades and decades of evidence and research," says Christopher Gardner, a nutrition expert at Stanford University.”

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...

Having a great time at the #AuPS2025 conference dinner. Great conference with great colleagues!

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

A famous graphic, now updated, compares locomotion in the animal kingdom

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

Nominations are now open for the AuPS Publication Prizes — and they close on 15 October 2025. 🧪 Student Publication Prize 🔬 Postdoctoral Publication Prize If you’ve published something you’re proud of, why not put yourself forward? 👉 Check out the AuPS website for all the details.

RACMEM 2025 Important notice Registrations will close on the 30th September (or when venue capacity is reached if sooner). Late registrations will not be accepted. If you wish to attend and didn't yet register this is your last chance. Please register at www.racmem.com Please retweet.

Published today in @cp-cellmetabolism.bsky.social, we report the unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice. Work by co-first authors Drs. Takuya Karasawa and Ran-Hee Choi. 1/

Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D www.nature.com/articles/s41...

First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins. www.nature.com/articles/s41...

Based on studies of mice with increased energy expenditure the authors propose myeloid CAMKK2 as a key regulator of macrophage function and a potential therapeutic target for treating #obesity and related metabolic disorders www.sciencedirect.com/science/arti...

This is a friendly reminder that early-bird registration and abstract submission for the 2025 AuPS annual meeting hosted by the University of Western Sydney in Paramatta is open until Friday 12/09/2025. Nominations for our prizes, grants and awards are also due tomorrow- exception Publication prize

An excellent write-up on our collective obsession with PROTEIN! by @erictopol.bsky.social. You may think you're not getting enough of it. But check out this article. Too many people are *overconsuming* protein. open.substack.com/pub/erictopo...

An amygdala–liver axis that regulates rapid glycaemic adaptations to stress and links recurrent stress to metabolic dysfunction www.nature.com/articles/s41...

Nature research paper: Structural basis for the dynamic regulation of mTORC1 by amino acids go.nature.com/3V8r3Lw

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

The 2025 AuPS Annual Meeting is open for registration and abstract submissions! 📍 Western Sydney University, Parramatta 📅 Sunday 23 – Wednesday 26 November Join us as we celebrate 65 years of Australian physiology and scientific excellence. Abstracts due 12 September www.aups.org.au

🌟 Early Career Physiologists – This is your moment! The A.K. McIntyre Prize celebrates outstanding contributions to Australian physiology 🧪 🏅 $1000 + medal 🎤 Invited talk in Queenstown 2026 🗓️ Apply by Sept 12 www.aups.org.au/Prizes/ for more information #ECR #ScienceAwards #Physiology #McIntyrePrize

www.nature.com/articles/s41... Imidazole propionate is a driver and therapeutic target in atherosclerosis Congrats to @sancholab.bsky.social and his team!

The role of metabolism in shaping enzyme structures over 400 million years | Nature share.google/7QQrLX8knlgD...

This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...

Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...

🎉 AuPS turns 65! Join us at the 2025 Annual Meeting at Western Sydney Uni (Parramatta) — 23–26 Nov Save the date Celebrate physiology, share your research, and connect with colleagues. Details soon! #AuPS2025 #Physiology #STEM

Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10.... We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial @nejm.org nejm.org/doi/full/10....

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. @annakrook.bsky.social @juleenrzierath.bsky.social @cbmr.science doi.org/10.1016/j.ce...

In Chinese adults with overweight or obesity, once-weekly #GLP/glucagon agonist mazdutide, at a dose of 4 mg or 6 mg for 32 - 48 weeks, led to clinically relevant #weightloss in the GLORY-1 trial. Very low drop out rates due to side effects www.nejm.org/doi/full/10....

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer www.nature.com/articles/s41... Massive congratulations to @rushika-perera.bsky.social Lab!!

Now online! Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors

Whoa!! www.nejm.org/doi/full/10....

Big thanks to @addgene.bsky.social for making our MoClo Baculo available as a kit! All the plasmids for Golden Gate assembly of baculovirus vectors, now bundled together: www.addgene.org/kits/davidov... 🧪🧬 #MolecularCloning #baculovirus #ProteinExpression

FGF21 signalling in the CNS and liver improve experimental metabolic liver disease in mice @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Delighted to share this new review article discussing the potential bidirectional communication between the liver and the central circadian clock. The systemic relationship is likely more complex than we thought! rdcu.be/egZWQ

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH: Cell Reports Medicine www.cell.com/cell-reports...

🚨 Abstract deadline 🚨 48th European Lipoprotein Club: eas-elc.org 👉 April 24th. If you love metabolism and related disorders this meeting is for you. Speakers: Ana Paula Arruda, Oliver Bruns, Antje Körner, Claudia Monaco, and Keynote Phil Scherer plus 35 talks selected from abstracts! Please repost

The world of science needs more colleagues like Dr. Kevin Hall. Honesty, integrity and high quality science, answering critical questions with broad implications for improving human health

My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...

www.nature.com/articles/s42... Metabolites are not genes. repeat, please!

Handgrip strength provides a window into mortality risk in people with severe #obesity www.nature.com/articles/s41...

Time change season is here! While most Australian states fall back from DST, QLD, WA & NT don't practice it. @benweger.bsky.social and I break down why this might be a win in our latest piece for The Conversation. ⏰☀️ @emcra-imb.bsky.social theconversation.com/daylight-sav...

New paper from the lab: Accelerated discovery of cell-migration regulators using label-free deep learning-based automated tracking. 840 experiments done in 70h instead of 5.5 years! Read here: www.biorxiv.org/content/10.1...