Matthew Potthoff (@potthofflab.bsky.social)

Please check out our latest paper in Cell Reports describing the mechanism for FGF21-mediated reversal of obesity. We identified that the hindbrain (NTS/AP) and NOT the hypothalamus is the target for FGF21 to decrease body weight. www.cell.com/cell-reports...

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Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain Lin et al. reveal that FGF21 acts on the hindbrain (nucleus of the solitary tract [NTS] and area postrema [AP]), and not the hypothalamus, to reduce body weight. Specifically, FGF21 signaling to the h... https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00171-3