Wonderful to have this published - a massive trans-Tasman effort spear-headed by @francis-middleton.bsky.social in his PhD to explore T-cells in rheumatic fever, including seeing CXCR3+ T cells in valve tissue. It highlights a need for new therapies that bock immune-cell migration and tissue damage

Get Primed on Acute rheumatic fever and rheumatic heart disease with our NEW PrimeView! FREE to download this week! www.nature.com/articles/s41...

NEW on our blog: Behind the paper: Māori and Pacific People’s perspectives on Group A Streptococcus vaccine development and delivery in Aotearoa, New Zealand speakingofmedicine.plos.org/2026/02/04/b...

Acute rheumatic fever is an autoinflammatory disease @njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....

Our latest work used Phip-Seq to explore the autoantibody repertoire in rheumatic fever ➡️ saw evidence of epitope spreading and identified a new disease associated antigen with biomarker potential 🧪 Great collaboration with MSSM and led by @rhcmcg.bsky.social and @laurencarlton.bsky.social at UoA

A recent update on Rapua, the initiate focused on accelerating Strep A vaccine development in Aotearoa New Zealand www.uniservices.co.nz/news/researc...

So many important insights on #StrepA immunity in this huge piece work by @alexjkeeley.bsky.social @thushan-desilva.bsky.social and the team in #TheGambia. A real privilege to have played a small role from down-under

There are multiple reports of dramatic reductions followed by surges in invasive Strep A disease post-pandemic, and now here is one on rheumatic fever, with incidence mirroring superficial infections in the community in Auckland New Zealand - led by Julie Bennett www.tandfonline.com/doi/10.1080/...

This deep dive into the clinical phenotype of rheumatic fever highlights extreme diversity in presenting symptoms. An important observation from the START study, and highlights why better diagnostic tests are needed 🧪 @annapralph.bsky.social @rhcmcg.bsky.social bmjopen.bmj.com/content/15/7...

The complete spectrum of serious #StrepA disease was observed in Auckland in 2023 - a mighty lab-based enhanced surveillance effort led by Andrew Fox-Lewis and Rachel Webb www.thelancet.com/journals/lan...

New preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...

Super excited announce funded @wellcometrust.bsky.social extend #StrepA Human challenge inc. transfer to Gambia & identify correlates of protection. Great team @joshosowicki.bsky.social @precisionvaxlab.bsky.social @njmoreland.bsky.social @thushan-desilva.bsky.social y.social & others not on Bluesky

📣Research Technician job alert! Needed to support our #iSpyLIFE field work and #strep biobanking. www.imperial.ac.uk/jobs/search-...

Following relaxation of #COVID19 restrictions surges in infections from respiratory pathogens like RSV and #StrepA have been seen in many countries including Aotearoa New Zealand. Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...

This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV

Finally jumping into 🦋 - and what better way to do than highlighting this super thread. Wonderful to have been involved in this study with our Strep A friends across the Tasman