so just reading the title - I would say there is a lot more to this than amnesia

A new study by @thushan-desilva.bsky.social @alexjkeeley.bsky.social & colleagues provides a framework for future Streptococcus pyogenes (Strep A) vaccine development by examining the natural acquisition of humoral immunity! www.nature.com/articles/s41... #Microbiology #Pathogen #VaccineDevelopment

Antibodies to conserved Streptococcus pyogenes antigens correlate with functional activity and protect Gambian children from culture‑confirmed infections, especially under age 2. by Keeley AJ, Camara FE (...) de Silva TI et 33 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

Beatriz Grinszetjn Opens #ias2025! While she can't provide a recipe for success in current climate, there are key factors 1. EVIDENCE 2. SOLIDARITY 3. TRUTH Let us make the most of our time together at the conference to "reaffirm, refocus & rebuild!" @iasociety.bsky.social

Prof de Silva & Dr Keeley speak on Strep A epi & immunity in the Gambia. 🗝️ Hyperendemicity of Strep A 🗝️ Index infections not explained by household contacts 🗝️ Early life immunity develops <2 y/o 🗝️ Ab response to carriage & infection 🗝️ ?protective immunity from SLO, SpyAD, SpyCEP #LISSSD25 #IDsky

This post just hits the nail on the head for me right now:

#ESCMIDGlobal2025 threads: Buckets of cool research and breaded meats.... Not seen a single post on #PEPFAR / #USAID cuts. How do we stand together as a community to strongly condemn this tragedy, and work on solutions? If it's not our problem #ESCMID "global" NOW, then who? and when?

Great thread and paper: Where #StrepA burden greatest frequent lineage replacement seen. Interesting points: "vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement." "need to do better surveillance from carriage and non-invasive disease"

★ NEW #Communicable out now! Today is Int'l Women's Day & to honour that we give you the first of a 2-part special on gender dynamics in medicine 🎙️ share.transistor.fm/s/21a9df96 #IDSky #clinmicro #IWD2025 @angelahuttner.bsky.social @erinmccreary.bsky.social @anniejoseph.bsky.social & more

If pubmed is inaccessible at the moment, try @europepmc.org

Can any other funders step in to take this on? These platforms are invaluable and so much research and health security would be lost "with immediate effect" Hard (and almost feels inappropriate/pointless) to focus on thesis writing right now #globalhealth #IDSky

10 years ago, when I began teaching global health, my courses were mostly the 'blue pill' version Slowly but surely, it has become reddish Every year brings more improvement & reflection @shashikalb.bsky.social & @ananyatb.bsky.social have been great co-teachers journals.plos.org/globalpublic...

Early life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high burden setting https://www.medrxiv.org/content/10.1101/2025.02.11.25322090v1

📢 Preprint - not peer-reviewed🤞: Development of #immunity to #StrepA in The Gambia. We assessed IgG to conserved and M protein antigens across the life course, exploring association with protection against infection: www.medrxiv.org/content/10.1... #IDSky #Immunosky

Excited to say that in collaboration with colleagues in Australia @latrobeuni.bsky.social we got NHMRC funding to use SpyCATS cohort to build state of the art #StrepA transmission models. Hope to ultimately better understand household transmission & help target interventions in high burden settings.

Healthcare - you get what you pay for £3600 the average Tax/person/year goes to #NHS £165 to General Practice Discussion yesterday with a US expat - £7600 basic US insurance cover for a fit & healthy 26yr old (still pay for use) Without the NHS what could you afford? Private GP appt £79 #Medsky

Great thread 👇 & 📜: A beautifully told story from complex serological data around @joshosowicki.bsky.social #StrepA human challenge. Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ... #IDSky

Wow - what mischief makers indeed!

Here's something I missed on #IDTwitter last year: www.nejm.org/doi/full/10.... Phase 3 trial of NmCV-5 (ACWYX) meningitis vaccine in 2-29yo. Randomized, double-blind, noninferiority study vs. quadrivalent MenACWY-D for immunogenicity/safety over 28 days. #IDSky - recreating the space we lost

New research article in The Lancet Microbe #Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study www.thelancet.com/journals/lan... #StrepA #MicroSky #IDSky #OpenAccess #OA

www.thelancet.com/journals/lan... @madhupai.bsky.social @shashikalb.bsky.social @CKyobutungic A must read: summary on barriers (politics/funders/institutions/culture) to redressing global health power imbalances. But.. “power concedes nothing without a demand. It never did and it never will.”

World feels pretty overwhelming right now... So please consider supporting: DEC donation.dec.org.uk/middle-east-... MSF msf.org.uk/secure/donate ..and this initiative by @madhupai.bsky.social: crowdfunding.mcgill.ca/ui/main/p/pa... to recognise those striving for equity in health.

Starkly putting out tensions between conferences & carbon footprints Worked example for @escmid.bsky.social confernce but it's generalisable Benefits of in-person meetings are at environmental cost not easily squared #IDSky 🩺 #AcademicSky www.clinicalmicrobiologyandinfection.com/article/S119...

100% - So challenging to quantify the benefits of the irreplaceable interactions, (whereas the harms can be quantified - www.nature.com/articles/s41...) but we must proactively consider this, given our collective goal to reduce ill-health/suffering. Can to share my own frame work if anyone via DM

Dear IDTwitter refugees I made an #IDSky starter pack which makes it easy to find accounts of ID clinicians, medical microbiologists, ID researchers, ID epidemiologists, ID focused reporters, and of course journals ahead of the curve. Let me know if I missed you! go.bsky.app/LnAQjdq

BALANCE is an RCT of 3,608 pts with bloodstream infections randomized to 7 vs 14 days antibiotics Excl: Staph aureus, S lugdunensis, fungi, deep seated infections, severe immunocompromise No dif in 90d mortality or relapse Firmly establishes 7d as SOC #IDSky www.idsociety.org/news--public...

Awesome! Eish tho does this go into my Zotero virology or microbiology collection?

A case of babesiosis acquired in the UK Increased prevalence of Babesia divergens in Ixodes ticks .... jumped to a human in this instance. #IDSky #MedSky #MicroSky wwwnc.cdc.gov/eid/article/...

What we're aiming for in a Shigella vaccine: O-specific polysaccharide (OSP)-specific functional IgA responses #immunosky #IDsky www.thelancet.com/journals/lan...