ft. @yeqiaoz.bsky.social, N. Burget, Tobias Friedrich, @faryabi.bsky.social (@pennpathlabmed.bsky.social), @atishayjay.bsky.social (Bioeng), S. Yoon & @vahedilab.bsky.social (@penngenetics.bsky.social) @pennepigenetics.bsky.social @i3h-upenn.bsky.social www.nature.com/articles/s41...

ft. M. Abedi, P. Rai, Y. Zhou, C. Liu, I. Johnson, A. Chandra, M. Fasolino, S. Rostami, W. Wang, Z. Min, Y. Li, M. Yu, @atishayjay.bsky.social, V. Lian, M. Silverman, @kkaestner.bsky.social, A. Naji, B. Faryabi & @vahedilab.bsky.social @penngenetics.bsky.social www.science.org/doi/10.1126/...

Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social tinyurl.com/4nwfbeu2 tinyurl.com/4zaw5cn7 tinyurl.com/25snbf4j

Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.

Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf

With co-first author, CAMB Alum, Yeqiao Zhou from her time in the Faryabi Lab (@faryabi.bsky.social)

How to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...

I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in @sciimmunology.bsky.social scim.ag/4o12TOZ

Congratulations to @ksusztak.bsky.social (@pennmedicine.bsky.social/ @penngenetics.bsky.social/ @chopresearch.bsky.social) on her election to the National Academy of Medicine! Learn more about Dr. Susztak & her research here➡️ www.med.upenn.edu/susztaklab/ #PSOMatNAM @nam.edu

Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu

In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...

Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...

🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Sometimes you only need to focus on good news: www.nytimes.com/2025/05/15/h...

The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5... Please ask questions in the Youtube comment section for Golnaz. Hope you enjoy it!

Looking forward to our next #globalimmuno talk this Wednesday, May 7th, at 9am PST, noon EST, 4pm GMT by Dr. Golnaz Vahedi. Title: “Chromatin topology at paralogous transcription factors” ZOOM LINK: ucsd.zoom.us/j/91053505061 LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS

It takes a special talent to observe the phenotype of an ETS1 super-enhancer deletion and see into the evolution of paralogous transcription factors. Holy 🤯, @vahedilab.bsky.social!

Congratulations to Katalin Karikó (@PennNSG), Virginia Lee (@pennpathlabmed.bsky.social), @ejohnwherry.bsky.social (@PennSysPharmATT) & Mark Devlin (@physatpenn) on their election to @nasonline.org! tinyurl.com/5eehdtms

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

Congrats to Atishay and Carlos for their review article on the epigenetics regulation of T cells: www.nature.com/articles/s41...

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data go.nature.com/43YySqO rdcu.be/ebBio

Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.

Disease diagnostics using machine learning of B cell and T cell receptor sequences www.science.org/doi/10.1126/... TL;DR: BCRs ARE ALL YOU NEED! (Well actually .... keep reading) 1/

Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...

This is outstanding. All academic scientists should be required to watch this.

🏆 Presenting the front page of tomorrow's Inquirer, memorializing the Eagles' second Super Bowl win.

This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...

"Pursuant to this Supplemental Guidance, there will be a standard indirect rate of 15% across all NIH grants for indirect costs in lieu of a separately negotiated rate for indirect costs in every grant." grants.nih.gov/grants/guide...

Go Birds!

In a paper published today in Science Immunology, a research team led by @elhamazizi.bsky.social has identified a specific population of immune cells that play a critical role in the successful treatment of relapsed acute myeloid leukemia (AML). www.engineering.columbia.edu/about/news/s...

Everyone should contact their senators/representatives to advocate for the NIH. Point out things like below. And like the fact that all new drugs have their point origin in NIH-funded research (then developed by Pharma/Biotech). The real impact of NIH has been lost in the noise of political BS

If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you

AAI congratulates the 2025 Class of Distinguished Fellows! These long-term members are honored for their outstanding scientific contributions and service to the #immunology community. See the complete list of 2025 honorees: ow.ly/aiXE50UHGW6.

I've said it before, but the most interacted-with part of your paper is the title, followed by the abstract and Fig. 1, then steeply downhill from there. Plan accordingly.

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

Re-posting given recent adds go.bsky.app/9asWtuD

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

TET2 regulates early & late transitions in exhausted CD8+ T cell differentiation & limits CAR T cell function ft. Alexander Dimitri, Gregory Chen, @JoeFraietta (@PennMicro/ @penncancer.bsky.social), @amylizbaxter (@PennSysPharmATT) & Martha Jordan (@PennPathLabMed) www.science.org/doi/10.1126/...

Excited to reconnect to the scientific community again. We are going to need each other's support more than ever in coming months.