Faryabi Lab @UPENN
@faryabi.bsky.social
📤 181
📥 60
📝 2
Interested in epigenetics, cancer biology, and learning!
pinned post!
Kudos to Yeqiao Zhou,
@atishayjay.bsky.social
, and
@vahedilab.bsky.social
for our new
@natcellbio.nature.com
study
www.nature.com/articles/s41...
! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.
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Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
https://www.nature.com/articles/s41556-025-01827-2
about 1 month ago
0
2
1
reposted by
Faryabi Lab @UPENN
Yeqiao Zhou
about 1 month ago
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable.
@faryabi.bsky.social
@vahedilab.bsky.social
@atishayjay.bsky.social
tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
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OLIVE provides rapid visualization and analysis of chromatin tracing experiments
Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.
https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00245-0
0
5
4
reposted by
Faryabi Lab @UPENN
Golnaz Vahedi
about 1 month ago
Beyond excited to share the collaborative work with
@faryabi.bsky.social
led by stars Yeqiao Zhou and
@atishayjay.bsky.social
; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology.
tinyurl.com/2st3afwf
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Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
https://www.nature.com/articles/s41556-025-01827-2
0
8
4
reposted by
Faryabi Lab @UPENN
CAMB Graduate Group
about 1 month ago
With co-first author, CAMB Alum, Yeqiao Zhou from her time in the Faryabi Lab (
@faryabi.bsky.social
)
add a skeleton here at some point
0
2
2
Kudos to Yeqiao Zhou,
@atishayjay.bsky.social
, and
@vahedilab.bsky.social
for our new
@natcellbio.nature.com
study
www.nature.com/articles/s41...
! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.
loading . . .
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
https://www.nature.com/articles/s41556-025-01827-2
about 1 month ago
0
2
1
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