Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://nej.md/4nWaxvM #ASCO26

Regarding ELNs, after all these years I still wish Findingsapp by @cparnot.bsky.social got resurrected. Benchling is fine, but Findings was such a joy to work with. Maybe in the age of LLMs it would be feasible to do that, add an optional web interface and collaboration features

The number of cancer deaths worldwide has more than doubled since the 1980s. Does that mean we're losing the fight against cancer? Not necessarily, because it depends on how you measure it. On this chart, you can see three ways to look at the same data. 🧵

A new tool from Rockefeller's @danmucida.bsky.social and @czbiohub.bsky.social allows scientists to closely follow newly activated T cells as they travel and change during an infection—it may inform future therapies for infection, cancer, and autoimmunity. 🔗: https://bit.ly/3NjZEWD

@ostendorflab.org, @immushuang.bsky.social, @sohailtavazoie.bsky.social et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. rupress.org/jem/article/... #TumorImmunology

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

📣 We’re hiring! Pls share! Join my lab to study human antigen-specific B cells across vaccination & infection backgrounds & explore their plasticity. Passionate about B cells, cutting-edge immunology, molecular biology & bioinformatics? 📄Details & apply: karriere.charite.de/stellenangeb... ⏳ Feb 28

“We found that using AI assistance led to a statistically significant decrease in mastery.” Props to Anthropic for studying the effects of their creation and reporting results that are not probably what they wished for www.anthropic.com/research/AI-...

A fascinating finding on the therapeutic potential of targeting non-coding regions of MYC!

New post! There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost. Medical breakthroughs in 2025. Plus a serious note at the end. www.scientificdiscovery.dev/p/medical-br...

Completely agree! Now I mainly wish for Prism and Flowjo replacements...

Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

What a great thread on budgeting for an academic lab!!

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃

Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...

We're very happy to invite you to the 𝟑𝐫𝐝 𝐘𝐨𝐮𝐧𝐠 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭 𝐂𝐚𝐧𝐜𝐞𝐫 𝐂𝐨𝐧𝐠𝐫𝐞𝐬𝐬 𝐚𝐭 𝐭𝐡𝐞 𝐅𝐫𝐞𝐧𝐜𝐡 𝐄𝐦𝐛𝐚𝐬𝐬𝐲 𝐢𝐧 𝐁𝐞𝐫𝐥𝐢𝐧 𝐨𝐧 𝐎𝐜𝐭𝐨𝐛𝐞𝐫 𝟗 &𝟏𝟎. Visit our website ys2c.org for further information.

We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region! jobs.sciencecareers.org/job/673667/j...

Presented at #ASCO25: The addition of encorafenib and cetuximab to mFOLFOX6 chemotherapy improved outcomes in the primary treatment of metastatic BRAF V600E–mutated colorectal cancer. Full BREAKWATER phase 3 trial results:

Excited to announce our preprint today @biorxivpreprint.bsky.social Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells: www.biorxiv.org/content/10.1...

Very happy that the first paper that started in our lab came out in @narjournal.bsky.social today ⭐🎊: BEscreen is a computational tool to design base editor sgRNA libraries for a broad range of use cases. It also allows for conveniently designing positive and negative controls and much more.

Hello, Bluesky! ☀️ We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late. Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

Americans are now one-third less likely to die from cancer at the same ages as Americans in 1990

Look who‘s here

Wishing the Elsevier editors who desk-accepted this all the best for their next career moves. doi.org/10.1016/j.ij...

Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025

🚨 One week left to apply! 🚨 Don’t miss the chance to join the Gaebler & Ibrahim Labs for a cutting-edge postdoc position at the intersection of viral immunology, virology & gene regulation. 👉Apply here charite.hrpuls.de/de/job-offer...

These are such good feeds. Time to scroll? Stay on Following. Just catching up? Go Mutuals or Only Posts. Wondering if you missed someone? Go Quiet Posters

Cancer Immunology: bsky.app/starter-pack... A repertoire of immunologists II: bsky.app/starter-pack... Immunometabolism: bsky.app/starter-pack... Immunoengineering: bsky.app/starter-pack... A repertoire of immunologists: bsky.app/starter-pack...

Restarting a previous discussion on here: How convinced are #SingleCell people by cell-cell communication methods? I'm still at "not very" 😅 I see them used everywhere, but I don't know of any really good way to validate them... More importantly, I don't know of any *non-simulated* training data.

another great cancer biology starter pack!

go.bsky.app/KxWyLE4 Trying to put together a starter pack for journals!

First post here. Our lab at MSKCC studies how #cancer form. Hoping for a vibrant and safe place to talk #science, connect with fellow #scientists, and inform the public about science and rationality. Interested in #genome_editing, #ecDNAs, #non-coding RNAs, and #cancer_biology

This week in Nature - four papers probe the relationship between ecDNA & cancer * an atlas of ecDNA in cancer * ecDNA inheritance in cancer during cell division * a potential way to leverage ecDNA for treatment * ecDNA role in tumour evolution & therapy resistance www.nature.com/nature/volum...

Here's another recent paper from the group describing the Fragmid resource, thread below. Paper is now published at Cell Genomics, and the kit is now available @addgene.bsky.social www.cell.com/cell-genomic... www.addgene.org/kits/doench-...

my main “bluesky tip” is simply — like and follow posts and people you enjoy seeing in your feed, and “show less” what you don’t enjoy. “training” Discover algorithm takes annoyingly long for now — but it does get more specific with time, and the team will be making it more responsive. data helps.

Dear everyone, I am closing down my twitter handle today and will be here full time from now on. Also migrated @leaddbs.bsky.social @netstim.bsky.social, @stimbrains.bsky.social and @braincircuits.bsky.social Let's build a better world together!

Really excited to have this out: a cell type-specific map of the impact of an understudied class of genetic variation (tandem repeats) on gene expression, at serious scale: nearly 1800 people with both WGS and blood scRNA-seq. So much signal!

Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate go.bsky.app/KJXNgfZ

📢 1.93 is rolling out now (2/5) To compose threads, start with your first post, then press the plus button!

At last, there's a searchable directory of Bluesky starter packs, courtesy of @mubashariqbal.com! Just one more way third-party developers are helping to make this place better. Search starter packs by keyword, and sort by "Uses" to see which ones people are finding the most helpful

With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here: go.bsky.app/TKp9YAn I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.

Fascinating and important data on cell state plasticity in #CRC #metastasis: Reverting back to (fetal) stem cell state allows a non-canonical differentiation in mets. Huge congratulations @KarunaMDPhD and team! Amazing to see this out! #ImmunoSky #organoids rdcu.be/dYAVK

Please share broadly! We (Molecular Genetics, University of Toronto) are looking for a new faculty member! Deadline Dec 19. Those working on model organisms and using genomics, computational and systems approaches are strongly encouraged to apply! Reach out w/ Qs! jobs.utoronto.ca/job/Toronto-...

A collection of papers from the Human Tumor Atlas Network (HTAN) published across Nature Portfolio journals present maps of tumours and their surrounding environments, including breast, colon and pancreas, which offer new insights into tumour biology. 🧪