Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social

🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm

first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!

Glad to see this out, very helpful resource for the community!

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity www.nature.com/articles/s41...

"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!

Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.

“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

🔬 #FundamentalResearch is key for #EUcompetitiveness

Someone finally said it out loud.

Amazing

Normalize calling Republicans Nazis.

Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: www.nature.com/articles/s41...

1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon @faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.

Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!

Cell identity lives from constraints and dies from freedom

Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!

Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇

1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social @owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity

Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social

Now online in Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, Kris Wood and colleagues doi.org/10.1158/2159...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13 onlinelibrary.wiley.com/doi/10.1111/...

You’re on fire @ciccarellilab.bsky.social! Congrats very interesting, I’m going to dig in it right away!

IMO, nonscientists consume science through proxies. When unbiased, education suffices. But for biased/malicious communication -e.g., crazy YouTube videos treated like peer-reviewed papers- preprints are a solution, not a problem. For one, that’s why we’re here & not on X…

Very helpful! Thanks for sharing this Victor! We’re going to test it right away!

Unless you’re the surgeon :)

A solved physics mystery that @barrallab.bsky.social will love! 😂😂😂 arxiv.org/pdf/2501.00536

The 2025 is the year of KRAS dosage: here is clinical evidence for high dosage correlating w/poor outcomes in PDAC: doi.org/10.1038/s415...

Intersting work Francesca @ciccarellilab.bsky.social, food for thought!

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?