🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume) www.researchsquare.com/article/rs-8...

Registration for Cancer Cell Plasticity closes on Monday 03 November! Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels: eacr.org/conference/c...

Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!

Unmissable for those working on melanoma and beyond.

Now online in Cancer Discovery for the #EACR2025 presentation by @marinelab.bsky.social: Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype doi.org/10.1158/2159... @vib-ccb.bsky.social @pozniakjoanna.bsky.social

Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social

rdcu.be/emi9N Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention

“Science has no passport, no gender, no ethnicity, no political party.” EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent. In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.

We are really looking forward to hosting YOU and these amazing speakers in Leuven. Whether you are a young trainee, an experienced postdoc or a leader in the field, please join us (you will not regret this!).

An important step towards personalised (combination) cancer treatments. vib.be/en#/ We are very excited about this project! Thanks to Oliver Bechter and his team and Presage for their trust and vision.

Great talk from my friend and colleague @cedric-blanpain.bsky.social (Chemoresistance) at the @helloeacr.bsky.social conference on Drug Tolerant Persister Cells (Lyon, France). Thanks to the organizers for this exciting event.

Please join us for this exciting event!!! Very much looking forward to the great talks and discussions on this 🔥 topic

Our latest piece "Decoding Melanoma’s Cellular Mosaic to Unlock Immunotherapy Potential" is available online: authors.elsevier.com/a/1khFK3QxxS... and will soon be published in @cp-trendscellbio.bsky.social. Thanks to @pozniakjoanna.bsky.social for taking the lead! Our Cover design proposal is below

Breaks are key to relaxed & unwind between sessions! This afternoon, @juliensage.bsky.social hit the courts with @marinelab.bsky.social & Lukas Dow - what better way to reset than a (maybe not so) friendly game of tennis🎾 #AMC25

Our excellent host, Julien Sage, sharing a surprising/unexpected role for T cells in the biology of small cell lung cancer …thanks Julien and Kevin for organising such a great @fusionconf.bsky.social (mouse models of cancer) conference!!

We took a deep dive into cancer progressions & metastasis this morning at #AMC25: 🧬Chris Marine on melanoma progression & therapy resistance 🐭 Eran Andrechek & Peter Westcott with cutting edge mouse models 🫁Katie Politi on progression & resistance in lung cancer 🌊Plus an exciting Catamaran tour⛵️

So cool!!

So happy to see this live, Slim! Congratulations to you, Ernesto and the whole team for your resilience, vision and creativity!

1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social @owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity

Congratulations Ginevra and the whole Fendt team! This is very exciting work!

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

Looking for an enthusiastic bioinformatician (long-term postdoctoral follow or staff scientist) interested in cancer/melanoma biology and therapy resistance. Data Science (single-cell, spatial multiomics integration), Machine learning, R, Pyhthon... jobso.id/ik9e

www.cell.com/cell/fulltex... My first post on BSKY will be a citation from Sydner Brenner (2002): "So genocentric has modern biology become that we have forgotten that the real units of function and structure in an organism are cells and not genes" highlighted by S Quake in this interesting piece.