A question for biologists: we often talk about evolutionary novelty. What does “novelty” mean for you? What’s your favorite definition if any? Or just a rule of thumb for what is and isn’t novel.

SIB Training organizes ~60 courses per year in the computational life sciences in Switzerland and online, which are open to attend for all researchers. We have launched a training needs survey. It takes 5-10 minutes to complete. forms.office.com/e/WmSxcBeMYX @sib.swiss

a strong moral principle to prevent me from deliberately stepping into the street, and methodically knocking people’s hats off

De-slop the text you shouldn't be writing anyway. A Claude skill to remove all the AI patterns from AI-generated text. blog.stephenturner.us/p/deslop Some before/after:

10x Flex Gene expression support is now part of the piscem -> alevin-fry workflow, and also has a nice, low-friction command in simpleaf! Check out the tutorial here (combine-lab.github.io/alevin-fry-t...). This was a major feature upgrade, so we're looking for testers and feedback :).

Sometimes you just get that shot. Anna's hummingbird with a little friend, in my yard. Davis, CA. #birds #ants

I've only skimmed the paper but this looks pretty impressive!

Integration of large, complex single-cell datasets with Harmony2 #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.03.16.711825v1

Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice. www.tandfonline.com/doi/full/10....

Piscem now supports reads with both sample-level and cell-leval barcodes github.com/COMBINE-lab/... : the corresponding changes in alevin-fry and simpleaf are incoming :). Want an easy path (rather than a complex workflow) to 10x Flex gene expression in alevin-fry, you got it!

Any good papers on the problems with meta-analysis when the outcome variable's data generating process is (zero-inflated) negative binomial and not well represented by mean/SD? Suggested solutions also appreciated #stats #rstats

I'm heading to #ADPD2026 tomorrow - drop me a line if you will be there too!

This is very cool! I remember talking through GitHub issues very early on with Will & I'm happy to see what they've built all this time later :). As a tool developer, I can't overstate the importance of having users willing to give you feedback, suggestions & find weird edge cases! Congrats!

Do you struggle with missing data in your statistical analyses? Come join our Summer School "Solving Missing Data Problems in R"! We will tell you when you can safely use complete case analysis, and when more dedicated strategies are required! utrechtsummerschool.nl/courses/data...

"Preprint servers are a time machine, they move everyone forward 12 months and speed up the exchange of ideas" ht @pedrobeltrao.bsky.social www.evocellnet.com/2021/06/a-no...

New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.

Let me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...

Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?...

🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells? 🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens

It's polite to credit the original www.latestly.com/social-viral...

With both AI haters & zealots flooding the zone with increasingly troll-ish posts, it's easy to forget most folks here are normal about the technology. Here's a thread of "normal folks posting about AI" that I enjoyed: 1/n

😅 We are also excited to be presenting a Omnibenchmark workshop at ECCB in Geneva in Aug/Sept .. eccb2026.org/tutorials-wo...

We're thrilled to announce the Ctrl-Z Award, a US$2,500 prize for researchers “who discover substantial errors in their published work and take meaningful steps to correct the scientific record." Covered by @nature.com today; read more here: centerforscientificintegrity.org/2026/03/10/a...

The empty drops you threw out in your single-cell RNA sequencing analysis might be hiding mysterious things 👀 check out our bioRxiv preprint! The empty drops do not contain cells. Yet we can still use them to learn interesting things about biology and technology. 1/

Data is necessary but not sufficient for understanding! (Thread is about a review that looks nice but I have not looked at yet)

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7

Immunotherapies for risk reduction in age-associated neurodegenerative diseases: impact of sex and treatment duration #NeuroDegeneration 🧪🧠 https://www.medrxiv.org/content/10.64898/2026.03.06.26347446v1

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.64898/2026.03.05.709922v1

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

i made a starter back of beautiful and unique manuscripts you can browse online! (with links) for anyone that wants a good way to spend an afternoon :) open.substack.com/pub/weirdmed...

Sparse autoencoders reveal organized biological knowledge but minimal regulatory logic in single-cell foundation models: a comparative atlas of Geneformer and scGPT #SingleCell 🧪🧬🖥️ https://arxiv.org/abs/2603.02952

GPU-accelerated single-cell analysis at scale with rapids-singlecell #SingleCell 🧪🧬🖥️ https://arxiv.org/abs/2603.02402

No matter the size or number, cats are always cats

Figure 1 in this paper is both informative and hillarious. The collider on self-perceived causal inference skill is too real

Scientists: for a new story, I have one big question—> What is a “good day” in the lab? I’m looking for epic examples of the best day ever to general criteria for what constitutes a “good day” compared to a nothing-burger day. Ping me if you have examples to share! Re-posts appreciated!

I'm constantly trying (/failing) to get this point across. If you're a trained expert in a field, then it may be worthwhile to question the scientific consensus of your peers. If you're not, the scientific consensus is absolutely the best you can do and it's arbitrary foolishness to disregard it.

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosis #NeuroDegeneration 🧪🧠 https://www.medrxiv.org/content/10.64898/2026.02.18.26346386v1

OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...

This afternoon I took my mom to the ballet. She was as a dancer and choreographer for decades & has been in memory care for 8 years. She can’t recall many details of her past but dance—and her identity as a dancer—lives in her soul 1/ #alzheimers

Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins #NeuroDegeneration 🧪🧠 https://www.medrxiv.org/content/10.64898/2026.02.12.26345733v1

Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance @naturemedicine.bsky.social nature.com/articles/s41...

Three postdoctoral fellowships in quantitative biology are available as part of a new Quantitative Biology Initiative in the Department of Biology at the University of Maryland. Best consideration date: 3/14 Job Ad: umd.wd1.myworkdayjobs.com/en-US/UMCP/j... Department: biology.umd.edu/people

The Zampieri Lab at the University of Basel is recruiting a highly motivated PhD candidate to investigate how metabolic programs drive cancer metastasis. 📩 Only applications submitted through the official recruiting system of the University of Basel will be considered. jobs.unibas.ch/offene-stell...

Very excited to get to share culmination of this large-scale project to understand spatial gene expression in schizophrenia. Really proud of the amazing team work here working out lots of roadblocks to deploy these spatial strategies and analysis methods at scale!

Everything is awful but there's a chance we will get this image on the cover of a special issue about statistical workflow. Really the best advertising decision the journal could make. I hope they go for it

Delighted to present Latent Interaction Variational Inference (LIVI), a framework for trans-eQTL mapping at single-cell resolution that I developed during my PhD together with colleagues from @steglelab.bsky.social 1/n

Postdoc alert in spatial biology! Building upon our previous work with MSI cancers (e.g. de Vries et al, Nature, 2023), the Voest Group at the NKI is hiring a (fully funded) postdoctoral fellow with strong expertise in spatial cancer biology. Learn more / apply here: www.nki.nl/careers-stud...

Parameter-free representations outperform single-cell foundation models on downstream benchmarks #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.02.11.705358v1

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

Bluesky is the new science Twitter, new study by @whysharksmatter.bsky.social and Julia Wester concludes! "Results show that for every reported professional benefit that scientists once gained from Twitter, scientists can now gain that benefit more effectively on Bluesky than on Twitter."