From Adaptive DBS to Adaptive Circuit Targeting 👇👇

Next steps ahead for DBS! 👇👇

Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇

New Institute paper out 👇👇

How should we best model recruitment of axons by deep brain stimulation? Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications: academic.oup.com/braincomms/a...

Super excited for Ningfei Li to receive the highly prestigious NSFC Excellent Young Scientists Fund – as of yesterday, Ningfei is Full Professor at the Xian University and has joined a new AI institute! We are both excited to continue our collaboration on @lead-dbs.org and connectomic DBS!

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇 stimulatingbrains.org/72-john-rols...

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery? How does RNS for epilepsy really work? Are we ready for stem cell therapy in PD? DBS for disorders of consciousness? Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested! lnkd.in/eEbnXByJ

@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI! @braincircuits.bsky.social

Hard to keep track about all the great things our labmembers have achieved recently:

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively. Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET Register here: partners.zoom.us/webinar/regi...

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

Can brain injury cause the loss of visual imagination? We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social www.medrxiv.org/content/10.1...

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor www.nature.com/articles/s41...

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇

Patient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation? @lukasgoede.bsky.social says yes – new study here: onlinelibrary.wiley.com/doi/10.1002/... A 🧵 @netstim.org @braincircuits.bsky.social @lead-dbs.org

First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

Tune in here for a fantastic primer on ECT – and so much more! Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...

Truly inspiring episode about a life lived in neurosurgery across 🇨🇦 and the 🇺🇸, from ventriculography- & frame-based procedures including ablative lesions in neuro & psych to intraoperative MRI all the way to carrying out over 600 lesions using MR guided focused ultrasound. Tune in below 👇👇

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...

Research defined the optimal DBS response network in STN-DBS for Parkinson’s Disease in a spatial domain. Other research defined physiomarkers for DBS response locally, in a temporal domain. However, nobody has analyzed these two concepts simultaneously. Enter @bahnebahners.bsky.social 👇👇

🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--

Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!

Lighting effects.. 🎉💥

I learned so much from a very sharp mind in this conversation. Equipped w an undergrad mathematics at Harvard, Medschool at Harvard, PhD at MIT, Terry has begun deeply thinking about dystonia and neuromodulation early on and has come up with a very unique sEEG based approach to treat tough cases.

We had a wonderful conversation with Dr. Terry Sanger from CHOC who is a very inspirational figure and innovator in the field of DBS – with a special focus on treating pediatric forms dystonia / cerebral palsy. Tune in here 👇👇 stimulatingbrains.org/69-terrence-...

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

Adaptive DBS was recently approved by the FDA – in this episode, we talk with @toddherrington.bsky.social about the underlying ADAPT-PD trial, the mechanism of action of DBS, and the potential role of stem cell therapy in movement disorders. Tune in here 👇🎧👇🎧 stimulatingbrains.org/68-todd-herr...

Had a really insightful conversation with @toddherrington.bsky.social, the director of the DBS program at @massgeneralbrigham.bsky.social MGH about adaptive DBS, stem cell research and novel forms of neuromodulation! Tune in here 👇🎧👇🎧

Can an entire treatment course of TMS for depression be condensed into a single day? Find out in this very inspiring conversation with Jonathan Downar here: stimulatingbrains.org/67-jonathan-...

Had a wonderful conversation with Jonathan Downar on @stimulatingbrains.org – Jonathan is one of the folks who may make you feel you have been wasting your time for the last years – but does so in a positive, very inspiring way. Certainly one of the key thought leaders in the neuromod space! Tune in

Lead-DBS v3.2 is out now – featuring Lead-Tutor, lots of code fixes and improvements, as well as some new atlases. Read all about it here: www.lead-dbs.org?na=view&id=31

Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!

Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social

Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results? This new tool from the @netstim.org lab lets you compare your performance against experts. Spearheaded by Savir Madan & @laurenahart.bsky.social

Want to learn Lead-DBS yourself? This is now possible thanks to a new dataset and tool extension created by Savir Madan & @laurenahart.bsky.social – out now in @apertureohbm.bsky.social 👇👇

Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.

En route to Kobe already! 🇯🇵 Who else is coming? Folks interested in joining the lab (and everyone else of course) feel free to approach me!

I am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!

Viewpoint: Recent disruptions and funding cuts at the National Institutes of Health (NIH) undermine the infrastructure and stability of US scientific research, threatening the nation's global leadership and scientific productivity. ja.ma/41hBnoc #MedSky