Check out this paper that unlocked the human brain networks behind tics. The research team recorded signals during tic and tic-free states revealing the rhythms that seem to drive tic generation. What was cool was that all participants had brain leads placed into two different regions.

Boom: The results of the ADAPT-PD personalized brain stimulation trial showed promise for treating Parkinson’s. First longer-term results for adaptive DBS in PD. Adaptive stimulation automatically adjusts in real time to a person’s brain signals. @parkinsondotorg.bsky.social

Should we be poking more holes in the brain-first vs body-first Parkinson’s theory? The brain-first body-first hypothesis suggests Parkinson’s may begin in either the brain (olfactory bulb or amygdala) or the body (gut, skin, kidney) and then spread. Espay and Lees describe the evidence.

What is the update for skin biopsies to differentiate Parkinson's vs. MSA? Spoiler alert: under confocal microscope, skin biopsies look different in PD vs MSA. Donadio and colleagues describe in a new paper in Brain the uses of intraneural phosphorylated α-synuclein. @parkinsondotorg.bsky.social

The book, The Parkinson’s Plan is back on Oprah Daily w/ 7 practical tips for prevention and for brain health. Prevention means identifying risks and taking action, before symptoms start. How about shifting care models toward prevention and lifestyle interventions? www.oprahdaily.com/life/health/...

A 2025 update on 'multi-site neurostimulation' and how it is making its move into the treatment toolbox for Parkinson's, Tourette, OCD and other neuropsychiatric conditions. Neurostimulation means using electricity to modulate brain networks and also using it to reduce symptoms of brain diseases.

How long does a Parkinson’s tremor stay on one side of the body? Spoiler alert: In more than half of cases it stays on one side. Tremor, which usually begins on one side, may spread across the body over time. In science terms, contralateral simply means moving to the opposite side of the body.

A surprising result from a randomized treatment trial of an ataxia treatment: high intensity aerobic exercise beat out simple balance training. Until now, treatment has focused mainly on balance training. The new randomized study found something unexpected.

Air pollution and Lewy body dementia: A wake-up call. A new study published in Science revealed that fine particle pollution (PM2.5) does not simply worsen general dementia risk. It may directly promote Lewy body dementia (LBD). @sfn.org

To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. @parkinsondotorg.bsky.social

Five year outcomes for Vercise deep brain stimulation (DBS) in Parkinson's disease are in, and they look very good. Specific features: independent control of each contact, rechargeable batteries, directional leads to steer current and MRI compatibility. @parkinsondotorg.bsky.social

Does air pollution lead to or potentially worsen Alzheimer’s related brain changes? Spoiler alert: YES, there is a convincing association that we should all pay attention to. Kim and colleagues provide compelling evidence that the air we breathe may worsen Alzheimer’s disease pathology.

Pesticides are drifting above us, and for diseases like Parkinson’s and Alzheimer’s, drifting 'chemical filled clouds' will be bad news for everyone. A new study revealed that pesticides are not just in the soil and water, they are traveling long distances and accumulating in cloud water.

Acupuncture offers relief for older adults w/ chronic low back pain w/ or without Parkinson. A new randomized trial published in JAMA Network Open by DeBar and colleagues tested acupuncture in 800 older adults and found sustained improvements in both pain and [email protected]

Neurosyphilis: an old foe resurfaces. A new review reminds us to never take our eye off of any disease. Neurosyphilis is not just history it is a pressing modern challenge. Rates of syphilis are the highest since the 1950s, and neurologic complications are once again front and center.

Please check out this new book on preventing Parkinson’s, co-written by my friend @michaelokun.bsky.social . He’s a leader on PD, & was so helpful & kind to me when I was caring for Mark, as we faced his PD together. It seems PD is everywhere these days, so any prevention is helpful!

Who is tired of waiting for a Parkinson's disease appointment with a specialist neurologist? Spoiler alert: We need a new plan for access. Ben Walter from Cleveland Clinic and Laurice Yang from Stanford have used 'big data' approaches to tackle this challenge. Parkinson's Disease Clinical Conference

Happy Birthday NINDS. The Parkinson's Plan www.pdplan.org calls for a 10X investment into research, and we are so grateful for NIH. Saw this amazing article in Annals of Neurology by Walter Korshetz and wanted to share so everyone knows what a big deal NIH and NINDS is, and will be, to our efforts.

Deep brain stimulation of the thalamus is known to help many tremors but what about POLR3A? Spoiler alert: Clinical features proved conducive for applying DBS as a way to create relief for the tremor. Nice paper and video in Tremor and Other Hyperkinetic Disorders by SÁNCHEZ-ROMÁN and colleagues.

Chronic pain is one of the most under-recognized burdens for folks with Parkinson’s disease. It is time we bring chronic pain in PD out of the shadows and address it as a central part of a care plan. Ogonowski and colleagues tackle this topic head on in a new article in Annals CTN.

The clue to unlocking Parkinson’s may be all around us. In his NY Times opinion piece that dropped today, Nick Kristof highlights how environmental exposures are shaping the world’s fastest growing neurodegenerative disease. He describes how the book,The Parkinson’s Plan, changed his behavior.

Can't get DBS? What are the real access challenges folks are having? Deep brain stimulation or DBS is one of the most effective treatments for Parkinson’s disease, especially when motor fluctuations set in. However, real-world access remains unequal. @parkinsondotorg.bsky.social

Can 'light therapy' help people w/ Parkinson’s sleep better? The ENLITE-PD randomized study put this idea to the test. Aleksandar Videnovic and colleagues did a great job on this multi-center effort. Spoiler alert: bright white light therapy was not effective. @parkinsondotorg.bsky.social

Smiling tremor: a rare twist in essential tremor or possibly task specific tremor. I recently learned about a man whose cheeks would tremble every time he smiled. This paper just dropped in Movement Disorders Clinical Practice by Chen and colleagues on the topic. @sfn.org

A randomized trial of lysergide for anxiety just dropped in JAMA, and it is 'big.' A single dose of lysergide showed meaningful and dose dependent improvement in generalized anxiety disorder. This may have meaningful implications for diseases like Parkinson’s and [email protected]

Can we merge the precision of connectomics w/ the flexibility of adaptive deep brain stimulation also referred to as DBS? A new Nature Reviews Neurology article makes the case for a unified framework: adaptive circuit targeting or ACT. Could this be the next frontier for Parkinson's and beyond?

Turning folks onto adaptive DBS is not a 'walk in the park.' Here is a new 'possible' programming strategy just published. Let's keep sharing and helping persons w/ disease seeking adaptive DBS for Parkinson's and beyond. www.nature.com/articles/s41... @parkinsondotorg.bsky.social

This important new study in Movement Disorders looked at folks w/ REM sleep behavior disorder, a common early sign of Parkinson’s. The results suggest that fMRI may reveal changes in brain networks long before symptoms of PD or dementia w/ Lewy bodies fully emerge. @parkinsondotorg.bsky.social

Tonight at the DBS Think Tank we welcome keynote speaker Kamil Ugurbil, a pioneer whose work was critical in creating the field of functional MRI or fMRI. His discoveries changed neuroscience and opened the door to imaging the living human brain in action. @parkinsondotorg.bsky.social

Neuroscience and society. Folks this is definitely an important 'thing.' We need to pay attention as technology begins to overtake society. Tune in virtually here to catch all of the great discussions this morning at the DBS Think Tank. ufl.zoom.us/webinar/regi... @parkinsondotorg.bsky.social

DBS Think Tank Scientific Sessions start on zoom at 1:00PM as soon as Nobel Laurette Stanley Prusiner finishes his talk and takes questions. We are off to a great start. Here are the first two sessions for today in case you are interested in listening in. @sfn.org @parkinsondotorg.bsky.social

A new study in Movement Disorders highlights the role of the somato-cognitive action network or SCAN in focal dystonia. Today marks the start of the DBS Tank and I will be asking Nico Dosenbach: When you keynoted the DBS Think Tank a few short years ago, did you imagine the impact of SCAN imaging?

First session DBS Think Tank at 115PM EST tomorrow: Doris Wang, Eduordo Martin Moraud and Marie-Laure Welter kick it all off w/ Next Generation Neuromodulation for Gait. Join us virtually from Sept 2-4th for the DBS Think Tank XIII. "The Evolving Landscape of DBS: New Indications, New Goals".

Do you know the 'why' behind Nobel Prize winner Stanley Prusiner's discovery of prions? Watch the lead off talk for the DBS Think Tank XIII Tomorrow Sept 2nd. Join us virtually from Sept 2-4 for DBS Think Tank XIII. We will highlight "The Evolving Landscape of DBS: New Indications, New Goals".

The world's largest sand battery just launched in Finland! Developed by Polar Night Energy, this is a massive step for clean energy. It stores 100 MWh of thermal energy in sand, providing cost-effective alternative to LI batteries for long-term heat storage. www.pv-magazine.com/2025/08/28/w...

What is the 2025 update on antibody therapies for Alzheimer’s? Spoiler alert: think EAC or effectiveness, access and cost. A critically important topic in a recent piece in JAMA. Early adopters enthusiastic, safety signals remain consistent w/ trials, questions remain. @alzassociation.bsky.social

If you are terrified of being bitten by a snake like me, arm yourself w/ knowledge from this new JAMA article. 1- Move to a safe area and call 911 if bitten. 2- Remove jewelry near the bite before swelling increases. 3- Do not apply tourniquets, pressure bandages, ice or herbal remedies. @sfn.org

Have you been missing the 'head snap sign?' The head snap sign, first described in essential tremor, may actually reach beyond essential tremor into thalamic tremor and possibly other disorders. @essentialpod.bsky.social @sfn.org

Have you heard of the triglyceride-glucose index to measure Parkinson's progression? Spoiler alert: We will soon be seeing many new ways to use biomarkers to measure PD progression. We are entering an exciting era where simple blood based measures may help us predict true disease progression.

The DBS Think Tank Rising Star Challenge is underway. Six finalists are now presenting their brilliant work live on zoom 1:00-3:30PM EST. DBS Think Tank Sept 2-4th next week. fixel.ufhealth.org/think-tanks/... @parkinsondotorg.bsky.social

Why 7000 steps is the right number for Parkinson’s and beyond. What do I tell the folks in my clinic? The 3 D's: Death, Dementia and Depression. For years people have asked me how many steps they should aim for each day. New evidence: 7000 steps or their equivalent. @parkinsondotorg.bsky.social

Three-photon imaging is opening a new window into the living brain. To truly move the Parkinson’s and neurodegenerative disease field forward, we need tools that let us see what was previously invisible. Three-photon microscopy or 3PM is one of those potentially transformative technologies.

The Parkinson’s Plan is now a New York Times Bestseller. As exciting as this news is, we are calling on you to join the movement. It is time. Just as the world rallied around polio, HIV and breast cancer, the moment has arrived for Parkinson’s disease. @parkinsondotorg.bsky.social

Do you know the 2025 update on vestibular dysfunction in Parkinson’s? Does dizziness plague you? New evidence highlights how the balance system may play a bigger role in Parkinson’s than we thought. A new systematic review. @parkinsondotorg.bsky.social @asapresearch.parkinsonsroadmap.org

Boom: Music may shape the infant brain. Early exposure to music does more than build rhythm. A new randomized study published in PNAS revealed music strengthens the pathway for a babies’ brain to process both music and speech. #neurology @sfn.org

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

🚨 New preprint out! 🚨 “Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application” 🔗 doi.org/10.1101/2025...  🧵 A short thread:

This is very exciting as it could provide a way to identify stimulation targets for syndromes for which no stimulation data exists at all as long as there is some genetic data. Congratulations!

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...