What might the future of deep brain stimulation look like? Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits. Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

Patient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results? This new tool from the @netstim.org lab lets you compare your performance against experts. Spearheaded by Savir Madan & @laurenahart.bsky.social

A fantastic resource for science communication: Openly available icons illustrating different Parkinson’s disease symptoms, created by @patriciazvarova.bsky.social with patient feedback. Explore them here: osf.io/ybcah/

jamanetwork.com/journals/jam... Thread below👇

Interested in modeling DBS induced white matter activations? Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling: www.medrxiv.org/content/10.1...

🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...

We report an interesting case of late-onset Pelizaeus-Merzbacher-like disease 1, diagnosed via genetic testing in a patient with decades-long progressive spasticity and tremor. Explore it now in Movement Disorders Clinical Practice! movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission! www.researchgate.net/publication/...

Today at noon ET - make sure not to miss these talks about evoked potentials in neuromodulation. Registration is free.

Today we say goodbye to @bahnebahners.bsky.social who spent the last year with us as a Thiemann visiting fellow – safe travels, don't be a stranger & thank you so much for bringing so much fun, joy and science into the lab & the @braincircuits.bsky.social!

First paper to ever use a 12-year-old feature of Lead-DBS which is to visualize graph networks, implemented still during the PhD of @andreashorn.org and pretty obscure in a tool called lead groupconnectome. Achtzehn et al. on STN-DBS ➔ Cognitive Control: onlinelibrary.wiley.com/doi/10.1002/...

Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.

Updated DBS starter pack including numerous new folks – @raynorproject.bsky.social @parkinsondotorg.bsky.social welcome to @bsky.app! go.bsky.app/B9A9Cho

New to #BlueSky and interested in following people who treat and study movement disorders? #NeuroSky #MedSky #AcademicSky Link (not exhaustive): go.bsky.app/F4ZDiMh

Join us on stimulatingbrains.org! Looking forward to it!

What an incredible episode of Stimulating Brains from Prof. @andreashorn.org with guests Prof. Susan Boehnke and astronomy CEO Mark McAuley. They covered a lot of important ground from Mark's Parkinson's diagnosis to the challenges he faced getting DBS to.. stimulatingbrains.org/63-mark-mcau...

Make sure not to miss this session of @stimbrains.bsky.social next Thursday! Free registration link attached.

We’re still looking for one more MSc or PhD student to join our lab @USherbrooke! 🇨🇦 Canadian students can start as early as January! We have many ongoing projects in neuroimaging of epilepsy and early brain development. More info here 👉🏼👉🏽👉🏾 slic-lab.github.io

Upon popular demand I created a started pack for people interested in Deep Brain Stimulation! Lmk if you'd like to be added! go.bsky.app/B9A9Cho

Movement disorders starter pack. Hopefully not exhaustive. Please spread the word and expand this group. go.bsky.app/F4ZDiMh

🚨🥁Preprint alert: #DBS Programming is currently a tedious trial and error process that involves testing many settings – each time asking the patient to perform motor tasks to see how things improve. Could we use DBS-#evokedpotentials to guide programming?doi.org/10.1101/2024.1…

Super cool work, @lukasgoede.bsky.social and @bahnebahners.bsky.social ! Since tweetorial seems outdated, want to do a skydive into your paper?

Great to see more people joining BlueSky! I’ll be more active here too, starting off with our latest preprint on a novel approach using DBS-evoked potentials to streamline and enhance DBS programming. www.medrxiv.org/content/10.1...