New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

🧠⚡ New year, fresh StimBrains talks! Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS. January session (Thurs, Jan 29, noon ET / 6pm CET) feat. the amazing @andrewpines.bsky.social & Nicola Cascella ✨ Get Zoom link here: talks.stimulatingbrains.org

What is the status of DBS for epilepsy? Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/ A 🧵 — please RT for reach! 🙏

Super excited about this!

Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq

Are connectome-based network mapping methods and the >200 papers that have used it invalid? New paper out in @NatureNeuro says YES. nature.com/articles/s41... I have concerns about this new paper's methods and conclusions, but am biased. What do others think?

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵 rdcu.be/eVZ1A

The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu

🚨 New preprint out! 🚨 “Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application” 🔗 doi.org/10.1101/2025...  🧵 A short thread:

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social

Mixed Bag #22: Nils Wendel on Learning Psychopharmacology Wendel explores the topic using a book, a concept, a person, an article, and a surprise item www.psychiatrymargins.com/p/mixed-bag-...

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...

The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis. Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3 www.medrxiv.org/content/10.1...

We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression. wd1.myworkdaysite.com/en-US/recrui... Please RT.

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...

A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social

We think of white matter as the brain's highways—uniform conduits between cortices. But what if we study development along tracts? Turns out the journey matters as much as the cortical destination! We're thrilled to share “Two Axes of White Matter Development” www.biorxiv.org/content/10.1... 1/n

Proud to share the first of our two-part sequel papers on the #TUS-#DBS project! t.co/yrGRcdpjXn We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

We could not be more thrilled to welcome this amazing class to Brigham!

🧠 We are #hiring! Postdoc @stanfordmedicine.bsky.social: help us develop closed-loop EEG platforms to improve TMS treatment for depression! Coding and neuroscience / engineering backgrounds required. Join our team! precisionneuro.stanford.edu email: [email protected]

Goodbye study sections: www.nih.gov/news-events/...

The Cohen Lab of Translational Neuroimaging is looking to hire a bioinformatics and research data scientist to help accelerate our research and develop new analysis tools! @bostonchildrens.bsky.social @braincircuits.bsky.social Please consider applying or sharing! jobs.brassring.com/TGnewUI/Sear...

JAMA Psychiatry Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target jamanetwork.com/journals/jam...

Awesome work by @barbarahollunder.bsky.social showing how 4 different diseases that can all be modulated at a tiny nuclei (STN) can be differentiated by white matter tracts (to be a little hipster: I’ve been a fan of this since it was a preprint)

Really thought-provoking talk by @julianneumann.bsky.social going over many things, including STN DBS but not Sinemet decreases cortical beta, and a super interesting theory about closed-loop timing of stimulation to beta phase

Super cool talk by @karaannjohnson.bsky.social showing how evoked resonant neural activity (ERNA) can be used to guide DBS localization, direction, and (possibly even) more!

Compelling talk by the one and only Shiro Horisawa on Forels field ablations in dystonia. Fantastic revival of a great historical target.

Great talk as always by @karaannjohnson.bsky.social complementing insights about ERNA in GPi DBS and dystonia.

Very interesting talk by Dr. Bohui Qian about common targets for movement and psychiatric disorders. They have implanted pts with coccurring disorders with great results. Dr.Qian is finishing her neurosurgery residency and planning on psych residency after! Super impressive-come to Boston!

We’re thrilled to hear from Dr. Andreas Horn, this year’s Brain Stimulation Early Career Award winner, at #BrainStimConf today! Congratulations on this well-deserved recognition @andreashorn.org #BrainStim2025 @braistimjournal.bsky.social @braincircuits.bsky.social

Super deserving of his award, @andreashorn.org identified specific tracts for specific diseases and even specific symptoms -> patient improvements in mx independent cohorts.

Do you know the Parkinson’s Iceberg? Great talk by @colinwhoy.bsky.social on adaptive DBS using ECoG based sensing here at #brainstimconf

Amazing company for dinner, organized by the great Shiro Horisawa. Thank you for the cake to celebrate @andreashorn.org, my first Kobe beef, and great conversations sure to inspire future connections!

Thanks @fof.se for highlighting our research! 🙌 Using 7T MRI, Tobias Navarro-Schroeder (@kavlintnu.bsky.social) & I study #TransientGlobalAmnesia as a model for reversible #hippocampal inactivation & #memoryloss across disorders. #Transdiagnostic approach is 🔑 to study circuit-symptom relationships!

This is an opportunity to do some of the coolest science out there AND be supported by one of the best mentors around!

Thank you for highlighting our work in this article 🙏 www.medscape.com/viewarticle/... jamanetwork.com/journals/jam...

jamanetwork.com/journals/jam... Thread below👇