We don't think it invalidates the approach. We looked into this in our data and replicated the key result showing convergence to non-specific connectome structure. However, our results also suggest there is a practical fix that is already implemented in some LNM studies. bsky.app/profile/pete...

This is a robust response. I particularly liked this figure - clarifying why the original critique showed what it did, and what was missing @foxmdphd.bsky.social

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

New @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now: academic.oup.com/brain/advanc... A 🧵:

Can a brain injury make someone lose their imagination? We describe rare cases of acquired aphantasia, people who lost the ability to visually imagine after a stroke or other brain injury. Now published in Cortex 🧠 @braincircuits.bsky.social www.sciencedirect.com/science/arti...

One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social learn.hms.harvard.edu/programs/bra...

The Shingles vaccine and reduction of dementia: a new natural experiment from Canada replicated 3 others and adds to this week's link to slowing of biological aging. erictopol.substack.com/p/spotlight-...

The Shingles vaccine has outperformed all expectations. Why? erictopol.substack.com/p/spotlight-...

Thanks to The Transmitter for reaching out to me for comments on this methodological challenge to lesion network mapping. Scientific debate is critical to methodological advancement - so let the debate begin! www.thetransmitter.org/brain-imagin...

Are connectome-based network mapping methods and the >200 papers that have used it invalid? New paper out in @NatureNeuro says YES. nature.com/articles/s41... I have concerns about this new paper's methods and conclusions, but am biased. What do others think?

New pre-print out now from Dr Daniel Corp, @jjoutsa.bsky.social and @foxmdphd.bsky.social ‘Mapping the neuroanatomy of dystonia using causal brain lesions’ !! www.medrxiv.org/content/10.6... We map networks for the different dystonias, showing significant differences, somatotopy...and much more!!

Very interesting findings! Gliomas selectively locate within in the Action-mode Network, using glioma network mapping derived from lesion network mapping @foxmdphd.bsky.social

Check out our new work on the relationship between glioma and system-level functional networks! We identify that nearly all gliomas localize within a common brain functional network, Action-Mode Network (AMN) . biorxiv.org/content/10.64898/2026.01.05.697608v1

Excited to share that our new review, "Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis," is out now in Biological Psychiatry! We propose MS as a powerful model for studying how white matter network changes contribute to depression.

What is the burden in the US of Parkinson's, Alzheimer's and other diseases? Spoiler alert: there are surges beyond the pure numbers and we need to raise awareness for the increases in both disability and burden. Parkinson disease has shown the largest growth in burden on society. cutt.ly/xtyUtS0D

Mongay-Ochoa et al. review advanced methods for mapping brain connections and identify common topographical patterns of pathology spread across different neurological disorders, including MS, AD and PD. tinyurl.com/3sz8ayup

Pruckner et al. show that the structural effects of neurosurgery extend beyond the resected tissue into connected networks through transneuronal degeneration. They were able to reliably predict these changes from preoperative MRI. tinyurl.com/a6rxvbey

🧪 Research Spotlight: Ziad Nahas, MD, MSCR, is studying how brain networks regulate mood in #BipolarDisorder & how instability drives shifts between depression & mania with PACE 👉 Goal: Test if targeting networks can improve mood & reveal mechanisms behind switches. 🔗 bit.ly/4gTbBwU

🧪 Research Spotlight: Michael Fox, MD, PhD (@foxmdphd.bsky.social) of Mass General Brigham (@mgbresearch.bsky.social) will map brain circuits driving symptoms in #BipolarDisorder 👉 Goal: Go beyond imaging correlations to identify the circuits causing symptoms. 🔗 bit.ly/4gTbBwU

This is 🤯 All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool. #neuroskyence #mri #brainmapping A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...

Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social: www.biologicalpsychiatryjournal.com/article/S000... 🧵

Can we identify brain circuit targets to treat symptoms of bipolar disorder? Thanks to funding from @bipolardiscoveries.org our team @braincircuits.bsky.social will be working hard to find out! Honored to be one of these excellent teams. www.news-medical.net/news/2025102...

From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...

Suzanne Haber was just elected to the National Academy of Medicine! Her work on the organization of the cortex and basal ganglia has had a huge impact. Please take the opportunity to congratulate her the next time you see her. www.urmc.rochester.edu/news/story/u...

Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!

Could the Parkinson’s drug levodopa prime the brain to respond better to intensive rehabilitation following a stroke or injury? Enter the idea: Let’s give dopamine pills after a stroke? Spoiler alert: This new large, randomized trial published in JAMA revealed no added benefit in recovery.

Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day. Great insights from @anastasiayendiki.bsky.social @mghmartinos.bsky.social, @fredschaper.bsky.social @braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.

Boom: The results of the ADAPT-PD personalized brain stimulation trial showed promise for treating Parkinson’s. First longer-term results for adaptive DBS in PD. Adaptive stimulation automatically adjusts in real time to a person’s brain signals. @parkinsondotorg.bsky.social

What is the update for skin biopsies to differentiate Parkinson's vs. MSA? Spoiler alert: under confocal microscope, skin biopsies look different in PD vs MSA. Donadio and colleagues describe in a new paper in Brain the uses of intraneural phosphorylated α-synuclein. @parkinsondotorg.bsky.social

In #DeepBrainStimulation the two major developments across the last decade have been 1. Adaptive DBS and 2. Connectomic DBS In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask: Could the two be united into a common framework? www.nature.com/articles/s41... A 🧵

Can connectomic DBS go beyond where to stimulate to inform who and when? Great discussion @dbsthinktank.bsky.social with @rolstonjohn.bsky.social @julianneumann.bsky.social suggest yes! @braincircuits.bsky.social

🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!

A nasal spray reduced the risk of Covid infections in a double blind, placebo controlled randomized trial jamanetwork.com/journals/jam...

Remarkable. Uncontrollable laughing or crying can happen *without* emotion ("pseudobulbar affect"). Here's a video of one individual whose crying is triggered by real or imagined rubbing of his finger & thumb. Intense response but not sadness. /1 static-content.springer.com/esm/art%3A10...

🚨 New preprint out! 🚨 “Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application” 🔗 doi.org/10.1101/2025...  🧵 A short thread:

Sending off 2 of our best research assistants ‬to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social

News from ENIGMA-Epilepsy! 🧠 Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients. Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge. Read more 👉 doi.org/10.1093/brai...

🚨 New Preprint 🚨 Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects By Cyr et al. *** Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES? A: Yes! 🧵:

Can specialized physical therapy help you to live longer with Parkinson’s? What if physical therapy did more than improve balance and reduce falls? Specialized physical therapy, like that provided through the PDNet model linked to a modest but real reduction in mortality for people w/ Parkinson’s.

Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!

Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b

Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.

Can dogs really smell Parkinson’s? Spoiler alert: Yes. A new study by Rooney and colleagues in the Journal of Parkinson’s Disease confirms what many people have long suspected. Dogs can be trained to detect Parkinson’s just by sniffing oily skin swabs. @parkinsondotorg.bsky.social #parkinson

Can we rewire and recover from an eating disorder? We must understand the actual underlying brain circuits. A terrific review in Nature Reviews Neuroscience urges us all to rethink eating disorders, not just as psychological struggles, but rather as disorders of brain circuitry. #bingeeating

Say cheese to detect Parkinson’s? Can AI see what doctors and healthcare providers miss? What if a simple smile could screen for Parkinson’s disease? A new study just published in NEJM AI shows that AI can potentially spot Parkinson’s simply by analyzing facial expressions. #parkinson

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Benchmarking methods for mapping functional connectivity in the brain | doi.org/10.1038/s415... What is the best measure of functional connectivity (FC)? led by @zhenqi.bsky.social in @natmethods.nature.com ⤵️

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social