New paper out in npj Digital Medicine! Fayed Rassoulou demonstrates how electrophysiology + machine learning can help identify the optimal contact for deep brain stimulation. rdcu.be/eNgG1

📈🧠 We're looking for brains! 🧠📈 Postdoc + PhD positions are available to help pioneer fetal MEG with optically pumped magnetometers, measuring prenatal responses to sound and light to understand how we start making sense of the world even before we're born. 🐣 Please get in touch to hear more!

There's still time to apply! #neurojobs

🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions shorturl.at/5Atjh

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

Big thanks to @patriciazvarova.bsky.social and @bahnebahners.bsky.social for their wonderful contributions, and to @andreashorn.org for his mentorship on this project! Read the full study here: onlinelibrary.wiley.com/doi/10.1002/...

🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

This is amazing work!

Congratulations to *Dr.* @barbarahollunder.bsky.social for a summa cum laude in her PhD earned at Charité today! Barbara is already a rock-star with multiple awards including the @dbsthinktank.bsky.social rising star award, an @ohbmofficial.bsky.social merit award and multiple German awards. …

Well done @barbarahollunder.bsky.social and I believe the excellent mentors deserve a lot of credit as well.

Very helpful to see this comprehensive view of what dopamine and DBS are doing in the cortico-basal ganglia loops!

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

Yeah they do Traveling Waves Integrate Spatial Information Through Time Blog: kempnerinstitute.harvard.edu/research/dee... Paper: arxiv.org/abs/2502.06034 #neuroscience

Had a wonderful conversation with Jonathan Downar on @stimulatingbrains.org – Jonathan is one of the folks who may make you feel you have been wasting your time for the last years – but does so in a positive, very inspiring way. Certainly one of the key thought leaders in the neuromod space! Tune in

Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication! We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.

Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.

Look what arrived in the mail today as a belated New Years gift – thanks Christian Lüscher & lab – very honored to be a remote lab member!

Super cool talk by @karaannjohnson.bsky.social showing how evoked resonant neural activity (ERNA) can be used to guide DBS localization, direction, and (possibly even) more!

Awesome work by @barbarahollunder.bsky.social showing how 4 different diseases that can all be modulated at a tiny nuclei (STN) can be differentiated by white matter tracts (to be a little hipster: I’ve been a fan of this since it was a preprint)

Second talk of @barbarahollunder.bsky.social at #BrainStimConf – great overview on STN-DBS for multiple disorders 👇👇 (paper here: www.nature.com/articles/s41...)

Really thought-provoking talk by @julianneumann.bsky.social going over many things, including STN DBS but not Sinemet decreases cortical beta, and a super interesting theory about closed-loop timing of stimulation to beta phase

I am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!

Do lesions that cause psychosis fall into a common brain network? Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here: jamanetwork.com/journals/jam...

Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

Honored to be invited by @foxmdphd.bsky.social to give a talk on mapping tremor response zones in thalamus @harvardmed.beky.social this Friday. It was a privilege to discuss with brilliant scientists like Dr. Cosgrove, Dr. Horn @andreashorn.org, Dr. Bubrick, and Dr. Siddiqi @shansiddiqi.bsky.social.

Interested in modeling DBS induced white matter activations? Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling: www.medrxiv.org/content/10.1...

This is going to be fantastic! 🙌 Aysu will talk about her multi center project on different targets for Tourette syndrome & Dr. Gunduz will give a fantastic talk on how engineering can play a role in neuroscience! Register here!!! stimulatingbrains.org/talk-series/ I can't wait!!!

New paper from Düsseldorf! 🧲 🧠 📝 MEG study on brain oscillations in corticobasal syndrome (CBS), a rare neurological disorder belonging to the so-called atypical Parkinson syndromes. Marius Krösche and Jan Hirschmann spearheaded this work. Just out now in 2025! www.sciencedirect.com/science/arti...

Do we need to stimulate different circuits to improve different dystonia symptoms with STN DBS? Work by Konstantin Butenko, @andreashorn.org @braincircuits.bsky.social out today in @PNAS says yes: Engaging dystonia networks with subthalamic stimulation | PNAS www.pnas.org/doi/10.1073/...

🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...

Had a fantastic conversation with Roxanne Lofredi on human (invasive) striatal recordings & her new @naturecomms.bsky.social paper, confirming & extending @russpoldrack.bsky.social's 'Stopping Triangle' using DBS stimulation mapping – tune in here: stimulatingbrains.org/66-roxanne-l...

Amazing review article and Bluesky-dive into the #Action-ModeNetwork by @ndosenbach.bsky.social

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

Happy New Year from Stimulating Brains! And we say thank you to 45,000 plays and the fantastic guests that took part in our neuromodulation podcast!

Cool to see our work from @braincircuits.bsky.social featured in @sciam.bsky.social today. Great read on an interesting and bizarre neurological condition. www.scientificamerican.com/article/how-...

Happy 2025 from the Center for Brain Circuit Therapeutics! 🪅🎈🍾🎉🥳

Combining hyposmia + mild DaT abnormalities helpful in picking out folks (early) who will have a potentially positive synuclein seeding assay in the spinal fluid. It will be really nice to continue to track folks. 'Hyposmic individuals with +aSynSAA at high risk for eventual clinical symptoms.'

Wow, non-invasive stimulation of the human hippocampus & entorhinal cortex during VR-navigation inside the MRI scanner! Impressive technical achievement and interesting result. By Beanato et al. www.science.org/doi/10.1126/...

What does a positive αSyn-SAA mean? ✅It supports a Parkinson's diagnosis. ✅It does not indicate disease mechanisms, severity, progression rate, biological subtypes, or treatment response. Important article: www.sciencedirect.com/science/arti... @albertoespay.bsky.social @ajlees.bsky.social

New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission! www.researchgate.net/publication/...

Check out this case of ATP1A3-Associated Paroxysmal Dystonia by LeDoux in the Tremor and Hyperkinetic Disorders Journal. Triggers can include chocolate. Did you know that paroxysmal episodes can be triggered by emotional excitement, heat, cold, exercise, chocolate, and menses. They may last 5 min.

My Final Visit With A Wizard + The Adventures of Tokkiri Dedicated to Dr. Alexandra Boogers tmrwedition.com/2024/12/18/m...

Tune in today to learn about #DBS-EvokedPotentials ⚡️🧠 and how we can use them to #map the therapeutic target in #Parkinson‘s disease and #Depression. Super excited that I am able to speak about my favourite #ephys topic together with @allisonwatersphd.bsky.social ! 🙌🏻📉📈📉📈📉📈📉

📢The Faculty of Medicine at the University of Tübingen invites applications for a position at the Hertie Center for Neurology for an Endowed #Professorship (W3) in #Neurology with a Focus on #Neurodegenerative #Diseases, available by 1 October 2026, potentially earlier Full PDF: tinyurl.com/y6bfky83

Is it critical to stimulate @ndosenbach.bsky.social's SCAN and CON networks for clinical improvements of Tourette's patients that undergo DBS? Carlos Baldermann says yes in a cool new paper out in @natureportfolio.bsky.social comms today! www.nature.com/articles/s41...