Sergiu Groppa
@segroppa.bsky.social
đ€ 868
đ„ 927
đ 20
Professor and Director of
#Neurology
, Saarland University, Germany www.uks.eu/neurologie
The hidden player in neurodegeneration and neuroinflammation - excited to share our latest review, newly published in Autoimmunity Reviews!
bit.ly/3ZTlHWV
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Imaging the hidden player: Choroid plexus enlargement in multiple sclerosis
The choroid plexus (CP), one key regulator of cerebrospinal fluid (CSF) production and immune surveillance at the bloodâCSF barrier, has recently emerâŠ
https://bit.ly/3ZTlHWV
4 months ago
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Delighted to share our review on therapeutic paths in myelin oligodendrocyte glycoprotein antibody-associated disease (#MOGAD). Clinically relevant work from our Neurology team at @UdS and amazing collaborators
bit.ly/48BLZRg
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Therapeutic approaches in adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of current evidence
Recent years have seen a considerable increase in knowledge pertaining to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). NevâŠ
https://bit.ly/48BLZRg
6 months ago
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New perspective on quantifying
#neurodegeneration
from
#MRI
bit.ly/4hFYIXw
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https://bit.ly/4hFYIXw
7 months ago
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We link pathological brain activity in PD with distinct signatures in
#microglia
,
#oligodendrocytes
and
#OPC
states and to specific mechanisms of abnormal protein folding, mitochondrial dysfunction and brain immunology in PD for future trials
bit.ly/3IoRFoP
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Cortical Single-Cell Primers of Abnormal Brain Activity in Parkinsonâs Disease | Research
Abnormal brain oscillatory activity is a well-established hallmark of bradykinesia and motor impairment in Parkinsonâs disease (PD), yet its molecular underpinnings remain unclear. To address this gap...
https://bit.ly/3IoRFoP
9 months ago
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Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh
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Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo
Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinsonâs disease; howe
https://shorturl.at/5Atjh
12 months ago
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Quantifying neurodegeneration is challenging, but a key prerequisite to modify disease courses. In this new review we discuss the opportunieties of structural covariance
#imaging
for tracking
#neurodegenerative
disorders.
#Neurology
#MultipleSclerosis
#ParkinsonsDisease
bit.ly/4j7lR4c
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Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders
Standard MRI focuses on brain structure but may not fully capture disease progression. Mongay-Ochoa et al. review advanced methods for mapping brain connec
https://bit.ly/4j7lR4c
about 1 year ago
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#Glycosphingolipidomics
alterations iincluding
#peripheral
#immunity
dependant profiles in
#Parkinsons
disease New Manuscript allert in
#NatComm
go.nature.com/43AalJZ
#Neurology
#Medicine
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Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinsonâs disease - Nature Communications
4D-TIMS-glycosphingolipidomics expedite clinical serum profiling of 376 GSLs covering ganglio- and neolacto-series, neutrals and sulfatides. Clinical phenotyping of Parkinsonâs disease cohort (sub)gro...
https://go.nature.com/43AalJZ
about 1 year ago
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Happy to share our new work on cortical sc scRNA profiles in
#Parkinsons
Disease. We see abnormal
#microglia
and
#oligodendrocytes
progenitors,modified mitochondrial function, energy consumption and altered immune activation.Huge basis for new therapeutic pathways development.
go.nature.com/3WgDIwR
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Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinsonâs disease - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Targeting pathological brain activity-related to neuroinflammation through scRNA-seq for new personalized therapies in Parkinsonâs disease
https://go.nature.com/3WgDIwR
over 1 year ago
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Enhancing declarative memory in
#PD
patients by sleep stage specific adaptation of
#DBS
frequency. A milestone for patients and future neurostimulation algorithms to modulate memory
bit.ly/4fu9rCp
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LowâFrequency Deep Brain Stimulation in NonâRapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease
Background and Objective Memory impairment is a frequent and debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof-of-principle that deep brain stimul...
https://bit.ly/4fu9rCp
over 1 year ago
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Captivating review on control of actions, adaptive, goal-directed behaviours and impulsive traits with an emphasis on the modulatory role of basal ganglia and subthalamic nucleus
academic.oup.com/brain/advanc...
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Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinsonâs disease
Herz et al. review recent studies that have used deep brain stimulation electrodes to record neural activity from, or apply electrical stimulation to, the
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae184/7692845
over 1 year ago
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Check our new book
link.springer.com/book/10.1007...
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Translational Methods for Parkinsonâs Disease and Atypical Parkinsonism Research
This volume covers translational paths used to study the pathophysiology of Parkinsonâs Disease such as molecular processes and tissue integrity.
https://link.springer.com/book/10.1007/978-1-0716-4083-8
over 1 year ago
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Check our new research work on choroid plexus alterations in COVID-19
doi.org/10.1002/ana....
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InflammationâTriggered Enlargement of Choroid Plexus in Subacute COVIDâ19 Patients with Neurological Symptoms
<em>Annals of Neurology</em> is a leading neurology journal from the American Neurological Association focusing on diseases of the human nervous system.
https://doi.org/10.1002/ana.27016
almost 2 years ago
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Similar morphometric brain alterations in patients with
#multiplesclerosis
and
#depression
. Read our latest work
bit.ly/3QZpnCw
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Concurrent inflammation-related brain reorganization in multiple sclerosis and depression
Neuroinflammation affects brain tissue integrity in multiple sclerosis (MS) and may have a role in major depressive disorder (MDD). Whether advanced mâŠ
https://bit.ly/3QZpnCw
about 2 years ago
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Comprehensive Review on the use of advanced therapies in
#Parkinsons
disease
bit.ly/3UjACrk
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Advanced therapies in Parkinsonâs disease: an individualized approach to their indication - Journal of Neural Transmission
Device aided therapies (DAT) comprising the intrajejunal administration of levodopa/carbidopa intestinal gel (LCIG) and levodopa/carbidopa/entacapone intestinal gel (LECIG), the continuous subcutaneou...
https://bit.ly/3UjACrk
about 2 years ago
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Excited to share our new work on motor control in patients with
#ParkinsonsDisease-continous
and online analysis of brain activity& adaptation of deep brain stimulation in dependancy of the performed movements led to an improved motor control in PD.Important next step for
#DBS
.
go.nature.com/49vO005
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Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control - Nature Communications
How movement speed is neurally modulated remains poorly understood. Here, the authors recorded invasive brain signals in Parkinsonâs disease patients during drawing and deep brain stimulation, showing...
https://go.nature.com/49vO005
about 2 years ago
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Major heterogeneity of the classical neurological disorders with a strong need of biological definitions and phenotype characterisations: important step for
#multiplesclerosis
research and future therapies - imaging, immune states & clinics for distinct phenotypes:
bit.ly/3U6RT7j
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Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories
Three discrete immunological endophenotypes in early multiple sclerosis correlate with distinct disease trajectories and treatment responses.
https://bit.ly/3U6RT7j
about 2 years ago
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#Tremor
is one of the most debilitating symptoms in
#Parkinson
disease. See our new work, that dissects by the aid of advanced electrophysiology fascinating new insights on tremor generators in
#PD
and how L-Dopa alleviates tremor. Relevant work for improved future treatments!
bit.ly/43zo3vc
about 2 years ago
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New review work from us on sarcoidosis related cerebral vasculitis and strokes
bit.ly/3TDxbvf
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Cerebral vasculitis as a clinical manifestation of neurosarcoidosis: A scoping review
The occurrence of cerebral vasculitis in individuals with neurosarcoidosis (NS) is considered to be rare. Although the number of relevant publicationsâŠ
https://bit.ly/3TDxbvf
about 2 years ago
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See our new work on stroke imaging with an advanced deep learning augmented protocol and highly accelerated scanning time
bit.ly/4c78gaE
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Ultrafast Brain MRI with Deep Learning Reconstruction for Suspected Acute Ischemic Stroke
Background Deep learning (DL)âaccelerated MRI can substantially reduce examination times. However, studies prospectively evaluating the diagnostic performance of DL-accelerated MRI reconstructions in ...
https://bit.ly/4c78gaE
over 2 years ago
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